scholarly journals Cell autonomous roles for AP-2α in lens vesicle separation and maintenance of the lens epithelial cell phenotype

2008 ◽  
Vol 237 (3) ◽  
pp. 602-617 ◽  
Author(s):  
Giuseppe F. Pontoriero ◽  
Paula Deschamps ◽  
Ruth Ashery-Padan ◽  
Ryan Wong ◽  
Ying Yang ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Lens Epithelial Cell ◽  
Cell Phenotype ◽  
Lens Vesicle

scholarly journals Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival

2009 ◽  
Vol 326 (2) ◽  
pp. 403-417 ◽  
Author(s):  
Giuseppe F. Pontoriero ◽  
April N. Smith ◽  
Leigh-Anne D. Miller ◽  
Glenn L. Radice ◽  
Judith A. West-Mays ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Survival ◽  
Lens Epithelial Cell ◽  
Lens Vesicle ◽  
E Cadherin

scholarly journals c-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formation

2011 ◽  
Vol 301 (2) ◽  
pp. C522-C529 ◽  
Author(s):  
Justine Elliott ◽  
Nadezhda N. Zheleznova ◽  
Patricia D. Wilson
Keyword(s):  
Cell Proliferation ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Collecting Duct ◽  
Specific Inhibitor ◽  
Cell Phenotype ◽  
Epithelial Cell Proliferation ◽  
Matrix Adhesion ◽  
Cyst Lining

c-Src is a non-receptor tyrosine kinase whose activity is induced by phosphorylation at Y418 and translocation from the cytoplasm to the cell membrane. Increased activity of c-Src has been associated with cell proliferation, matrix adhesion, motility, and apoptosis in tumors. Immunohistochemistry suggested that activated (pY418)-Src activity is increased in cyst-lining autosomal dominant polycystic kidney disease (ADPKD) epithelial cells in human and mouse ADPKD. Western blot analysis showed that SKI-606 (Wyeth) is a specific inhibitor of pY418-Src without demonstrable effects on epidermal growth factor receptor or ErbB2 activity in renal epithelia. In vitro studies on mouse inner medullary collecting duct (mIMCD) cells and human ADPKD cyst-lining epithelial cells showed that SKI-606 inhibited epithelial cell proliferation over a 24-h time frame. In addition, SKI-606 treatment caused a striking statistically significant decrease in adhesion of mIMCD and human ADPKD to extracellular collagen matrix. Retained viability of unattached cells was consistent with a primary effect on epithelial cell anchorage dependence mediated by the loss of extracellular matrix (ECM)-attachment due to α2β1-integrin function. SKI-606-mediated attenuation of the human ADPKD hyperproliferative and hyper-ECM-adhesive epithelial cell phenotype in vitro was paralleled by retardation of the renal cystic phenotype of Pkd1 orthologous ADPKD heterozygous mice in vivo. This suggests that SKI-606 has dual effects on cystic epithelial cell proliferation and ECM adhesion and may have therapeutic potential for ADPKD patients.

EAAT and Xc−Exchanger Inhibition Depletes Glutathione in the Transformed Human Lens Epithelial Cell Line SRA 01/04

2015 ◽  
pp. 1-10 ◽  
Author(s):  
Marlyn P. Langford ◽  
Thomas B. Redens ◽  
Chanping Liang ◽  
A. Scott Kavanaugh ◽  
Donald E. Texada
Keyword(s):  
Epithelial Cell ◽  
Cell Line ◽  
Lens Epithelial Cell ◽  
Human Lens ◽  
Epithelial Cell Line ◽  
Human Lens Epithelial Cell

scholarly journals The Molecular Chaperone αA-Crystallin Enhances Lens Epithelial Cell Growth and Resistance to UVA Stress

1998 ◽  
Vol 273 (47) ◽  
pp. 31252-31261 ◽  
Author(s):  
Usha P. Andley ◽  
Zheng Song ◽  
Eric F. Wawrousek ◽  
Steven Bassnett
Keyword(s):  
Cell Growth ◽  
Epithelial Cell ◽  
Molecular Chaperone ◽  
Lens Epithelial Cell
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