scholarly journals Using CRISPR/Cas9 engineering to generate a mouse with a conditional knockout allele for the promyelocytic leukemia zinc finger transcription factor

genesis ◽  
2019 ◽  
Vol 57 (3) ◽  
pp. e23281
Author(s):  
Lan Hai ◽  
Maria M. Szwarc ◽  
Denise G. Lanza ◽  
Jason D. Heaney ◽  
John P. Lydon
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Promyelocytic Leukemia ◽  
Conditional Knockout ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Zinc Finger Transcription Factor ◽  
Knockout Allele

scholarly journals The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization

PLoS Genetics ◽  
2016 ◽  
Vol 12 (4) ◽  
pp. e1005937 ◽  
Author(s):  
Ramakrishna Kommagani ◽  
Maria M. Szwarc ◽  
Yasmin M. Vasquez ◽  
Mary C. Peavey ◽  
Erik C. Mazur ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Stromal Cell ◽  
Promyelocytic Leukemia ◽  
Endometrial Stromal Cell ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Zinc Finger Transcription Factor ◽  
Human Endometrial Stromal Cell

scholarly journals The ETO Protein Disrupted in t(8;21)-Associated Acute Myeloid Leukemia Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein

2000 ◽  
Vol 20 (6) ◽  
pp. 2075-2086 ◽  
Author(s):  
Ari M. Melnick ◽  
Jennifer J. Westendorf ◽  
Adam Polinger ◽  
Graeme W. Carlile ◽  
Sally Arai ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Transcription Factor ◽  
Zinc Finger ◽  
Transcriptional Repression ◽  
Histone Deacetylases ◽  
Myeloid Leukemia ◽  
Histone Deacetylase Inhibitors ◽  
Promyelocytic Leukemia ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Acute Myeloid

ABSTRACT The ETO protein was originally identified by its fusion to the AML-1 transcription factor in translocation (8;21) associated with the M2 form of acute myeloid leukemia (AML). The resulting AML-1–ETO fusion is an aberrant transcriptional regulator due to the ability of ETO, which does not bind DNA itself, to recruit the transcriptional corepressors N-CoR, SMRT, and Sin3A and histone deacetylases. The promyelocytic leukemia zinc finger (PLZF) protein is a sequence-specific DNA-binding transcriptional factor fused to retinoic acid receptor α in acute promyelocytic leukemia associated with the (11;17)(q23;q21) translocation. PLZF also mediates transcriptional repression through the actions of corepressors and histone deacetylases. We found that ETO is one of the corepressors recruited by PLZF. The PLZF and ETO proteins associate in vivo and in vitro, and ETO can potentiate transcriptional repression by PLZF. The N-terminal portion of ETO forms complexes with PLZF, while the C-terminal region, which was shown to bind to N-CoR and SMRT, is required for the ability of ETO to augment transcriptional repression by PLZF. The second repression domain (RD2) of PLZF, not the POZ/BTB domain, is necessary to bind to ETO. Corepression by ETO was completely abrogated by histone deacetylase inhibitors. This identifies ETO as a cofactor for a sequence-specific transcription factor and indicates that, like other corepressors, it functions through the action of histone deactylase.

scholarly journals The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver‐Homing Receptors on Human Blood CD56 bright Natural Killer Cells

2020 ◽  
Vol 4 (3) ◽  
pp. 409-424 ◽  
Author(s):  
Leonard U. Hess ◽  
Glòria Martrus ◽  
Annerose E. Ziegler ◽  
Annika E. Langeneckert ◽  
Wilhelm Salzberger ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Zinc Finger ◽  
Human Blood ◽  
Zinc Finger Protein ◽  
Promyelocytic Leukemia ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Killer Cells ◽  
Finger Protein

scholarly journals The apple C2H2-type zinc finger transcription factor MdZAT10 positively regulates JA-induced leaf senescence by interacting with MdBT2

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Kuo Yang ◽  
Jian-Ping An ◽  
Chong-Yang Li ◽  
Xue-Na Shen ◽  
Ya-Jing Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Transcription Factor ◽  
Liquid Chromatography ◽  
Zinc Finger ◽  
Leaf Senescence ◽  
Transcriptional Activity ◽  
Molecular Mechanisms ◽  
Liquid Chromatography Mass Spectrometry ◽  
Zinc Finger Transcription Factor ◽  
Insight Into

AbstractJasmonic acid (JA) plays an important role in regulating leaf senescence. However, the molecular mechanisms of leaf senescence in apple (Malus domestica) remain elusive. In this study, we found that MdZAT10, a C2H2-type zinc finger transcription factor (TF) in apple, markedly accelerates leaf senescence and increases the expression of senescence-related genes. To explore how MdZAT10 promotes leaf senescence, we carried out liquid chromatography/mass spectrometry screening. We found that MdABI5 physically interacts with MdZAT10. MdABI5, an important positive regulator of leaf senescence, significantly accelerated leaf senescence in apple. MdZAT10 was found to enhance the transcriptional activity of MdABI5 for MdNYC1 and MdNYE1, thus accelerating leaf senescence. In addition, we found that MdZAT10 expression was induced by methyl jasmonate (MeJA), which accelerated JA-induced leaf senescence. We also found that the JA-responsive protein MdBT2 directly interacts with MdZAT10 and reduces its protein stability through ubiquitination and degradation, thereby delaying MdZAT10-mediated leaf senescence. Taken together, our results provide new insight into the mechanisms by which MdZAT10 positively regulates JA-induced leaf senescence in apple.

scholarly journals Promyelocytic Leukemia Zinc Finger Protein Activates GATA4 Transcription and Mediates Cardiac Hypertrophic Signaling from Angiotensin II Receptor 2

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e35632 ◽  
Author(s):  
Ning Wang ◽  
Gerald D. Frank ◽  
Ronghua Ding ◽  
Zhongjia Tan ◽  
Amita Rachakonda ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Promyelocytic Leukemia ◽  
Angiotensin Ii Receptor ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Finger Protein ◽  
Hypertrophic Signaling
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