CR1(CD35) and CR2(CD21) complement C3 receptors are expressed on normal human thymocytes and mediate infection of thymocytes with opsonized human immunodeficiency virus

1994 ◽  
Vol 24 (11) ◽  
pp. 2784-2788 ◽  
Author(s):  
Catherine-Charlotte Delibrias ◽  
Amal Mouhoub ◽  
Elizabeth Fischer ◽  
Michel D. Kazatchkine
Keyword(s):  
Human Immunodeficiency Virus ◽  
Complement C3 ◽  
Immunodeficiency Virus ◽  
Normal Human ◽  
C3 Receptors

scholarly journals Internalization of human immunodeficiency virus type I and other retroviruses by megakaryocytes and platelets

Blood ◽  
1990 ◽  
Vol 75 (10) ◽  
pp. 1920-1923 ◽  
Author(s):  
D Zucker-Franklin ◽  
S Seremetis ◽  
ZY Zheng
Keyword(s):  
Bone Marrow ◽  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Target Cells ◽  
Type I ◽  
Murine Bone Marrow ◽  
Immunodeficiency Virus ◽  
Normal Human ◽  
Normal Human Bone Marrow

Abstract Direct infection of megakaryocytes and platelets by human immunodeficiency virus type I (HIV-I) or other retroviruses has not been demonstrated. To determine whether this could occur, murine bone marrow was co-cultivated with the amphotropic retrovirus-producing cell line PA317-N2, and freshly isolated normal human bone marrow and platelets were co-cultivated with HIV-infected H9 cells. In each case, ultrastructural analyses showed viruses within megakaryocytes and platelets. In murine specimens, the uptake of retrovirus was avid at all stages of differentiation. In human specimens, viral uptake was less frequent. These results suggest that direct infection of megakaryocytes could play a role in the pathophysiology of HIV- associated disease. In addition, these observations suggest that cells of the megakaryocyte lineage could serve as target cells in gene transfer experiments using retroviral-based vectors.

scholarly journals The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain.

1987 ◽  
Vol 165 (4) ◽  
pp. 1230-1235 ◽  
Author(s):  
I Funke ◽  
A Hahn ◽  
E P Rieber ◽  
E Weiss ◽  
G Riethmüller
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Human Brain ◽  
Glial Cells ◽  
Northern Blot ◽  
Cellular Receptor ◽  
Cd4 Cells ◽  
Immunodeficiency Virus ◽  
Normal Human ◽  
Specific Mrna

The expression of the CD4 antigen in normal human brain was investigated in parallel by immunohistochemical and Northern blot analyses. With anti-CD4 antibodies detecting different epitopes of the molecule, CD4+ neurons were defined in the cerebellum, thalamus, and pons. CD4+ glial cells were identified in the thalamus and pons. CD4-specific mRNA was detected in all three subareas and in the hippocampus, while other subareas were negative. The CD4+ cells were negative with anti-T cell antibodies (anti-CD2 and anti-CD8), as well as with antimonocyte antibodies (M-M 522 and M-M 42).

scholarly journals Human Immunodeficiency Virus Type 1 gp41 Binds toCandida albicansvia Complement C3‐like Regions

1997 ◽  
Vol 176 (2) ◽  
pp. 492-498 ◽  
Author(s):  
Reinhard Würzner ◽  
Andreas Gruber ◽  
Heribert Stoiber ◽  
Martin Spruth ◽  
Ying‐Hua Chen ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Complement C3 ◽  
Immunodeficiency Virus

scholarly journals Inhibition of productive human immunodeficiency virus-1 infection by cobalamins

Blood ◽  
1995 ◽  
Vol 86 (4) ◽  
pp. 1281-1287 ◽  
Author(s):  
JB Weinberg ◽  
DL Sauls ◽  
MA Misukonis ◽  
DC Shugars
Keyword(s):  
Human Immunodeficiency Virus ◽  
Blood Monocytes ◽  
Inhibitory Effects ◽  
Immunodeficiency Virus ◽  
Normal Human ◽  
Enzyme Cofactors ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

Various cobalamins act as important enzyme cofactors and modulate cellular function. We investigated cobalamins for their abilities to modify productive human immunodeficiency virus-1 (HIV-1) infection of hematopoietic cells in vitro. We show that hydroxocobalamin (OH-Cbl), methylcobalamin (Me-Cbl), and adenosylcobalamin Ado-Cbl (Ado-Cbl) inhibit HIV-1 infection of normal human blood monocytes and lymphocytes. The inhibitory effects were noted when analyzing the monocytotropic strains HIV-1-BaL and HIV-1-ADA as well as the lymphocytotropic strain HIV-1-LAI. Cobalamins did not modify binding of gp120 to CD4 or block early steps in viral life cycle, inhibit reverse transcriptase, inhibit induction of HIV-1 expression from cells with established or latent infection, or modify monocyte interferon-alpha production. Because of the ability to achieve high blood and tissue levels of cobalamins in vivo and the general lack of toxicity, cobalamins should be considered as potentially useful agents for the treatment of HIV-1 infection.

Isolation of normal human follicular dendritic cells and CD4-independentin vitro infection by human immunodeficiency virus (HIV-1)

1991 ◽  
Vol 21 (8) ◽  
pp. 1873-1878 ◽  
Author(s):  
Ingrid Stahmer ◽  
J. Pascal Zimmer ◽  
Martin Ernst ◽  
Thomas Fenner ◽  
Ricarda Finnern ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Dendritic Cells ◽  
Follicular Dendritic Cells ◽  
Immunodeficiency Virus ◽  
Normal Human ◽  
Follicular Dendritic ◽  
Hiv 1
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