Coumarin 6 as a fluorescent model drug: How to identify properties of lipid colloidal drug delivery systems via fluorescence spectroscopy?

2014 ◽  
Vol 116 (9) ◽  
pp. 1234-1246 ◽  
Author(s):  
Jan Henrik Finke ◽  
Claudia Richter ◽  
Thomas Gothsch ◽  
Arno Kwade ◽  
Stephanus Büttgenbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Spectroscopy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Model Drug ◽  
Coumarin 6

scholarly journals A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 661 ◽  
Author(s):  
Jan Konasch ◽  
Alexander Riess ◽  
Robert Mau ◽  
Michael Teske ◽  
Natalia Rekowska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Additive Manufacturing ◽  
Inkjet Printing ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Blue Dye ◽  
Glycol Diacrylate ◽  
Coomassie Blue ◽  
The Matrix ◽  
Model Drug

Here, we present a new hybrid additive manufacturing (AM) process to create drug delivery systems (DDSs) with selectively incorporated drug depots. The matrix of a DDS was generated by stereolithography (SLA), whereas the drug depots were loaded using inkjet printing. The novel AM process combining SLA with inkjet printing was successfully implemented in an existing SLA test setup. In the first studies, poly(ethylene glycol) diacrylate-based specimens with integrated depots were generated. As test liquids, blue and pink ink solutions were used. Furthermore, bovine serum albumin labeled with Coomassie blue dye as a model drug was successfully placed in a depot inside a DDS. The new hybrid AM process makes it possible to place several drugs independently of each other within the matrix. This allows adjustment of the release profiles of the drugs depending on the size as well as the position of the depots in the DDS.

scholarly journals Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications

2015 ◽  
Vol 3 (8) ◽  
pp. 1688-1698 ◽  
Author(s):  
O. L. Galkina ◽  
V. K. Ivanov ◽  
A. V. Agafonov ◽  
G. A. Seisenbaeva ◽  
V. G. Kessler
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Active Ingredient ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cellulose Nanofiber ◽  
Potential Drug ◽  
Model Drug ◽  
Dermal Drug Delivery

Nanocomposites with potential for dermal drug delivery have been developed using nanotitania chemically grafted onto nanocellulose as an active ingredient for enhanced uptake and controlled release of model drug loads.

scholarly journals Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Abdolhossien Massoudi ◽  
Mohsen Adeli ◽  
Leila Khosravi far
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Citric Acid ◽  
Hydrogen Bonds ◽  
Drug Delivery Systems ◽  
Noncovalent Interactions ◽  
Delivery Systems ◽  
End Groups ◽  
Model Drug ◽  
Primary Drug

Pseudopolyrotaxanes (PPR) consisting ofα-cyclodextrin rings and polyethylene glycol axes with end thymine groups have been synthesized and characterized successfully. Fluorescein (Fl) as a model drug was conjugated to the hydroxyl functional groups of cyclodextrin rings of PPR via ester bonds and PPR-Fl as the primary drug delivery system was obtained. Finally PPR-Fl was capped by hydrogen bonds between end thymine groups and a suitable complementary molecule such as polycitric acid, citric acid, or adenine. The aim of this work was to control the release of the fluorescein-cyclodextrin (Fl-CD) conjugates, as the secondary drug delivery systems, from PPR-Fl by controlling the noncovalent interactions between stoppers and thymine end groups. It was found that the rate of release of the Fl-CD from PPR-Fl could be controlled by pH and the ratio of citric acid or adenine to the PPR-Fl.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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