scholarly journals Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Abdolhossien Massoudi ◽  
Mohsen Adeli ◽  
Leila Khosravi far
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Citric Acid ◽  
Hydrogen Bonds ◽  
Drug Delivery Systems ◽  
Noncovalent Interactions ◽  
Delivery Systems ◽  
End Groups ◽  
Model Drug ◽  
Primary Drug

Pseudopolyrotaxanes (PPR) consisting ofα-cyclodextrin rings and polyethylene glycol axes with end thymine groups have been synthesized and characterized successfully. Fluorescein (Fl) as a model drug was conjugated to the hydroxyl functional groups of cyclodextrin rings of PPR via ester bonds and PPR-Fl as the primary drug delivery system was obtained. Finally PPR-Fl was capped by hydrogen bonds between end thymine groups and a suitable complementary molecule such as polycitric acid, citric acid, or adenine. The aim of this work was to control the release of the fluorescein-cyclodextrin (Fl-CD) conjugates, as the secondary drug delivery systems, from PPR-Fl by controlling the noncovalent interactions between stoppers and thymine end groups. It was found that the rate of release of the Fl-CD from PPR-Fl could be controlled by pH and the ratio of citric acid or adenine to the PPR-Fl.

Anticancer drug delivery systems based on noncovalent interactions between carbon nanotubes and linear–dendritic copolymers

Soft Matter ◽  
2011 ◽  
Vol 7 (8) ◽  
pp. 4062 ◽  
Author(s):  
Mohsen Adeli ◽  
Farahman Hakimpoor ◽  
Masoumeh Ashiri ◽  
Roya Kabiri ◽  
Masoumeh Bavadi
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Noncovalent Interactions ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

Coumarin 6 as a fluorescent model drug: How to identify properties of lipid colloidal drug delivery systems via fluorescence spectroscopy?

2014 ◽  
Vol 116 (9) ◽  
pp. 1234-1246 ◽  
Author(s):  
Jan Henrik Finke ◽  
Claudia Richter ◽  
Thomas Gothsch ◽  
Arno Kwade ◽  
Stephanus Büttgenbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Spectroscopy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Model Drug ◽  
Coumarin 6

scholarly journals A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 661 ◽  
Author(s):  
Jan Konasch ◽  
Alexander Riess ◽  
Robert Mau ◽  
Michael Teske ◽  
Natalia Rekowska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Additive Manufacturing ◽  
Inkjet Printing ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Blue Dye ◽  
Glycol Diacrylate ◽  
Coomassie Blue ◽  
The Matrix ◽  
Model Drug

Here, we present a new hybrid additive manufacturing (AM) process to create drug delivery systems (DDSs) with selectively incorporated drug depots. The matrix of a DDS was generated by stereolithography (SLA), whereas the drug depots were loaded using inkjet printing. The novel AM process combining SLA with inkjet printing was successfully implemented in an existing SLA test setup. In the first studies, poly(ethylene glycol) diacrylate-based specimens with integrated depots were generated. As test liquids, blue and pink ink solutions were used. Furthermore, bovine serum albumin labeled with Coomassie blue dye as a model drug was successfully placed in a depot inside a DDS. The new hybrid AM process makes it possible to place several drugs independently of each other within the matrix. This allows adjustment of the release profiles of the drugs depending on the size as well as the position of the depots in the DDS.

scholarly journals Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications

2015 ◽  
Vol 3 (8) ◽  
pp. 1688-1698 ◽  
Author(s):  
O. L. Galkina ◽  
V. K. Ivanov ◽  
A. V. Agafonov ◽  
G. A. Seisenbaeva ◽  
V. G. Kessler
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Active Ingredient ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cellulose Nanofiber ◽  
Potential Drug ◽  
Model Drug ◽  
Dermal Drug Delivery

Nanocomposites with potential for dermal drug delivery have been developed using nanotitania chemically grafted onto nanocellulose as an active ingredient for enhanced uptake and controlled release of model drug loads.

Synthesis and Selfassambling of Amphiphilic Oligoesters Based on Pyromellitic Acid

2016 ◽  
Vol 10 (2) ◽  
pp. 159-172 ◽  
Author(s):  
Ihor Tarnavchyk ◽  
◽  
Andriy Voronov ◽  
Volodymyr Donchak ◽  
Olga Budishevska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Size Distribution ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Fatty Alcohols ◽  
Polyethylene Glycols ◽  
Pyromellitic Acid ◽  
New Class ◽  
Solubilization Capacity

The method for synthesis of a new class of amphiphilic oligoesters of pyromellitic acid is developed. As hydrophilic fragments polyethylene glycols or polyethylene glycol mono methyl ethers were used, as lipophilic ones – primary fatty alcohols or cholesterol. The structure of the synthesized oligoesters was confirmed by IR- and PMR-spectroscopy. The oligoesters could solubilize water-insoluble substances, for example such effective antitumor lipophilic drug as curcumin. The high solubilization capacity of the OEPA assemblies and their biodegradability, as well as other properties (size distribution, ζ-potential) make the oligoesters considered as promising materials for the design of drug delivery systems.

scholarly journals Polyethylene Glycol-Coated Gold Nanoparticles as DNA and Atorvastatin Delivery Systems and Cytotoxicity Evaluation

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
José Alberto Zamora-Justo ◽  
Paulina Abrica-González ◽  
Guillermo Rocael Vázquez-Martínez ◽  
Alejandro Muñoz-Diosdado ◽  
José Abraham Balderas-López ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Drug Delivery Systems ◽  
Transfection Efficiency ◽  
Delivery Systems ◽  
Cell Uptake ◽  
Imaging Studies ◽  
Human Embryonic Kidney Cell ◽  
Hek 293

The application of nanoscience and nanotechnology in medicine has been useful in the diagnosis, monitoring, and treatment of many diseases. Gold nanoparticles are commonly used for medical imaging studies, biosensors, drug delivery systems, and gene therapy. It has been reported that nanoparticles coated with specific polymers improve the biocompatibility and stability and decrease the cytotoxicity of the nanoparticles. In this work, we performed transfection studies of gold nanoparticles coated with polyethylene glycol, synthetized by two different methods, in a human embryonic kidney cell culture (HEK 293), by using plasmids pSV-β-Gal and pIRES2-EGFP. In addition, we also evaluated the cell uptake of a fluorescent drug (atorvastatin) using the synthetized gold nanoparticles as carriers. Furthermore, the study of cell viability after the interaction between these cells and the nanoparticles was performed. It was shown that the polyethylene glycol-coated gold nanoparticles presented transfection efficiency and cell uptake greater than 45% in each case. These results suggest that the synthetized gold nanoparticles coated with polyethylene glycol could be used successfully and safely as DNA and drug delivery systems.

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