Visceral and subcutaneous adipose tissue stearoyl-CoA desaturase-1 mRNA levels and fatty acid desaturation index positively correlate with BMI in morbidly obese women

2015 ◽  
Vol 117 (7) ◽  
pp. 926-932 ◽  
Author(s):  
Adriana Mika ◽  
Lukasz Kaska ◽  
Justyna Korczynska ◽  
Agnieszka Mirowska ◽  
Piotr Stepnowski ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Subcutaneous Adipose Tissue ◽  
Fatty Acid Desaturation ◽  
Morbidly Obese ◽  
Mrna Levels ◽  
Obese Women ◽  
Desaturation Index ◽  
Stearoyl Coa Desaturase ◽  
Subcutaneous Adipose

scholarly journals Downregulation of lipogenesis and fatty acid oxidation in the subcutaneous adipose tissue of morbidly obese women

Obesity ◽  
2014 ◽  
Vol 22 (9) ◽  
pp. 2032-2038 ◽  
Author(s):  
Teresa Auguet ◽  
Esther Guiu-Jurado ◽  
Alba Berlanga ◽  
Ximena Terra ◽  
Salomé Martinez ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Subcutaneous Adipose Tissue ◽  
Acid Oxidation ◽  
Morbidly Obese ◽  
Obese Women ◽  
Subcutaneous Adipose

scholarly journals Downregulation of de Novo Fatty Acid Synthesis in Subcutaneous Adipose Tissue of Moderately Obese Women

2015 ◽  
Vol 16 (12) ◽  
pp. 29911-29922 ◽  
Author(s):  
Esther Guiu-Jurado ◽  
Teresa Auguet ◽  
Alba Berlanga ◽  
Gemma Aragonès ◽  
Carmen Aguilar ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Subcutaneous Adipose Tissue ◽  
De Novo ◽  
Acid Synthesis ◽  
Obese Women ◽  
Subcutaneous Adipose

scholarly journals Increased postprandial fatty acid trapping in subcutaneous adipose tissue in obese women

2000 ◽  
Vol 41 (12) ◽  
pp. 1963-1968 ◽  
Author(s):  
David Kalant ◽  
Steve Phélis ◽  
Barbara A. Fielding ◽  
Keith N. Frayn ◽  
Katherine Cianflone ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Subcutaneous Adipose Tissue ◽  
Obese Women ◽  
Subcutaneous Adipose

scholarly journals Differential effects of reduced protein diets on fatty acid composition and gene expression in muscle and subcutaneous adipose tissue of Alentejana purebred and Large White × Landrace × Pietrain crossbred pigs

2013 ◽  
Vol 110 (2) ◽  
pp. 216-229 ◽  
Author(s):  
Marta S. Madeira ◽  
Virgínia M. R. Pires ◽  
Cristina M. Alfaia ◽  
Ana S. H. Costa ◽  
Richard Luxton ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Subcutaneous Adipose Tissue ◽  
Mrna Levels ◽  
Large White ◽  
Longissimus Lumborum ◽  
Subcutaneous Adipose ◽  
Crossbred Pigs ◽  
Imf Content

The present study assessed the effect of pig genotype (fatty v. lean) and dietary protein and lysine (Lys) levels (normal v. reduced) on intramuscular fat (IMF) content, subcutaneous adipose tissue (SAT) deposition, fatty acid composition and mRNA levels of genes controlling lipid metabolism. The experiment was conducted on sixty intact male pigs (thirty Alentejana purebred and thirty Large White × Landrace × Pietrain crossbred), from 60 to 93 kg of live weight. Animals were divided into three groups fed with the following diets: control diet equilibrated for Lys (17·5 % crude protein (CP) and 0·7 % Lys), reduced protein diet (RPD) equilibrated for Lys (13·2 % CP and 0·6 % Lys) and RPD not equilibrated for Lys (13·1 % CP and 0·4 % Lys). It was shown that the RPD increased fat deposition in the longissimus lumborum muscle in the lean but not in the fatty pig genotype. It is strongly suggested that the effect of RPD on the longissimus lumborum muscle of crossbred pigs is mediated via Lys restriction. The increase in IMF content under the RPD was accompanied by increased stearoyl-CoA desaturase (SCD) and PPARG mRNA levels. RPD did not alter backfat thickness, but increased the total fatty acid content in both lean and fatty pig genotype. The higher amount of SAT in fatty pigs, when compared with the lean ones, was associated with the higher expression levels of ACACA, CEBPA, FASN and SCD genes. Taken together, the data indicate that the mechanisms regulating fat deposition in pigs are genotype and tissue specific, and are associated with the expression regulation of the key lipogenic genes.

scholarly journals Eicosapentaenoic Acid Increases Browning Markers in Subcutaneous Adipose Tissue and Primary Adipocytes from Wild Type and UCP-1 Deficient Mice (P15-007-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Shasika Jayarathne ◽  
Mandana Pahlavani ◽  
Latha Ramalingam ◽  
Shane Scoggin ◽  
Naima Moustaid-Moussa
Keyword(s):  
Adipose Tissue ◽  
Eicosapentaenoic Acid ◽  
Subcutaneous Adipose Tissue ◽  
Uncoupling Protein ◽  
Fibroblast Growth Factor 21 ◽  
Chow Diet ◽  
Mrna Levels ◽  
Wild Type ◽  
Brown Adipose ◽  
Subcutaneous Adipose

Abstract Objectives Brown adipose tissue (BAT) regulates energy balance through thermogenesis, in part via uncoupling protein -1 (UCP-1). White adipose tissue (WAT), namely subcutaneous adipose tissue (SAT) can convert to a beige/brite adipose tissue phenotype (browning) under thermogenic conditions such as cold. We previously reported that eicosapentaenoic acid (EPA) reduced obesity and glucose intolerance, and increased UCP-1 in BAT of B6 mice at ambient temperature (22°C); and these effects were attenuated at thermoneutral environment (28–30°C). We hypothesized that EPA exerts anti-obesity effects on SAT, including increased browning, adipocyte hypotrophy; and these effects require UCP-1. Methods Six-week-old B6 wild type (WT) and UCP-1 knock-out (KO) male mice were maintained at thermoneutral environment and fed high fat diet (HF) with or without 36 g/kg of AlaskOmega EPA-enriched fish oil (800 mg/g) for 14 weeks; and SAT was collected for histological, gene and protein analyses. SAT was also prepared from chow diet-fed WT and KO mice at ambient environment to prepare stroma vascular cells, which were differentiated into adipocytes, treated with 100uM EPA for 48 hours then harvested for mRNA and protein analyses. Results KO mice fed HF diets had the highest body weight (P < 0.05) among all groups. EPA reduced fat cell size in both WT and KO mice fed the EPA diet. mRNA levels of fibroblast growth factor-21 (FGF-21) were higher in SAT of WT mice fed EPA compared to WT mice fed HF (P < 0.05), with no differences between the KO genotype. KO mice fed HF diets had lower levels of UCP-3 in SAT compared to WT mice fed HF (P < 0.05), which was rescued only in the KO mice fed EPA (P < 0.05). UCP-1 protein levels were very low in SAT tissues, and UCP-2 mRNA levels were similar across all groups in SAT. Interestingly, EPA significantly (P < 0.05) increased mRNA expression of UCP-2, UCP-3 and FGF21 in differentiated SAT adipocytes from both WT and KO compared to control. Furthermore, UCP-1 mRNA levels were significantly higher in WT adipocytes treated with EPA, compared to non-treated cells (P < 0.05). Additional mechanistic studies are currently underway to further dissect adipose depot differences in EPA effects in WT vs. KO mice. Conclusions Our data suggest that EPA increases SAT browning, independently of UCP-1. Funding Sources NIH/NCCIH.

Fatty Acid Composition of Subcutaneous Adipose Tissue in Mother-Infant Pairs

1987 ◽  
Vol 76 (1) ◽  
pp. 87-90 ◽  
Author(s):  
G. E. ANDERSEN ◽  
N. C. CHRISTENSEN ◽  
M. B. V. PETERSEN ◽  
K. B. JOHANSEN
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Subcutaneous Adipose Tissue ◽  
Subcutaneous Adipose
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