Preclinical evidence for pioglitazone and bexarotene combination in oral cancer chemoprevention

<p>Oral cancer survival remains poor despite advancement in treatment modalities. In oral cancer and oral premalignant lesions, cyclooxygenase-2 (COX-2) is widely expressed and tends to be enhanced especially in high-risk oral lesions. Numerous researches suggests that the inflammation pathway of cyclooxygenase/prostaglandin E2 (PGE2) leads to the development and progression of a number of cancers, including oral squamous cell carcinoma (OSCC). With an emphasis on research data, this article discusses the relationship between inflammation and cancer, summarizes the use of anti-inflammatory agents COX-2 inhibitors for cancer chemoprevention and treatment, and explains the mechanisms underlying the anti-cancer effects of anti-inflammatory agents (COX-2 inhibitors).</p>

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Selection of topically applied non-steroidal anti-inflammatory drugs for oral cancer chemoprevention

Oral Oncology ◽

10.1016/j.oraloncology.2005.01.003 ◽

2005 ◽

Vol 41 (6) ◽

pp. 562-567 ◽

Cited By ~ 20

Author(s):

Sandeep Sood ◽

Steven J. Shiff ◽

Chung S. Yang ◽

Xiaoxin Chen

Keyword(s):

Oral Cancer ◽

Cancer Chemoprevention ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Selection Of

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Development of the Bowman-Birk inhibitor for oral cancer chemoprevention and analysis of neu immunohistochemical staining intensity with Bowman-Birk inhibitor concentrate treatment

The Laryngoscope ◽

10.1097/00005537-200310000-00007 ◽

2010 ◽

Vol 113 (10) ◽

pp. 1687-1702 ◽

Cited By ~ 39

Author(s):

William B. Armstrong ◽

X. Steven Wan ◽

Ann R. Kennedy ◽

Thomas H. Taylor ◽

Frank L. Meyskens

Keyword(s):

Oral Cancer ◽

Immunohistochemical Staining ◽

Cancer Chemoprevention ◽

Staining Intensity ◽

Concentrate Treatment

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A Novel Target for Oral Cancer Chemoprevention? Notch Quite, Yet…

Cancer Prevention Research ◽

10.1158/1940-6207.capr-15-0057 ◽

2015 ◽

Vol 8 (4) ◽

pp. 262-265 ◽

Cited By ~ 4

Author(s):

William N. William ◽

Adel K. El-Naggar

Keyword(s):

Oral Cancer ◽

Cancer Chemoprevention ◽

Novel Target

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Oral Carcinogenesis and Oral Cancer Chemoprevention: A Review

Pathology Research International ◽

10.4061/2011/431246 ◽

2011 ◽

Vol 2011 ◽

pp. 1-10 ◽

Cited By ~ 45

Author(s):

Takuji Tanaka ◽

Mayu Tanaka ◽

Takahiro Tanaka

Keyword(s):

High Risk ◽

Oral Cancer ◽

Cancer Risk ◽

Molecular Mechanisms ◽

Cancer Chemoprevention ◽

Field Cancerization ◽

Targeted Prevention ◽

Chemopreventive Agents ◽

Oral Cancers ◽

Oral Carcinogenesis

Oral cancer is one of the major global threats to public health. The development of oral cancer is a tobacco-related multistep and multifocal process involving field cancerization and carcinogenesis. The rationale for molecular-targeted prevention of oral cancer is promising. Biomarkers of genomic instability, including aneuploidy and allelic imbalance, are possible to measure the cancer risk of oral premalignancies. Understanding of the biology of oral carcinogenesis will yield important advances for detecting high-risk patients, monitoring preventive interventions, and assessing cancer risk and pharmacogenomics. In addition, novel chemopreventive agents based on molecular mechanisms and targets against oral cancers will be derived from studies using appropriate animal carcinogenesis models. New approaches, such as molecular-targeted agents and agent combinations in high-risk oral individuals, are undoubtedly needed to reduce the devastating worldwide consequences of oral malignancy.

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