scholarly journals Liver Proliferation Is an Essential Driver of Fibrosis in Mouse Models of Nonalcoholic Fatty Liver Disease

2019 ◽  
Vol 3 (8) ◽  
pp. 1036-1049 ◽  
Author(s):  
Ashley Cast ◽  
Meenasri Kumbaji ◽  
Amber D'Souza ◽  
Katherine Rodriguez ◽  
Anita Gupta ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Mouse Models ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Liver Proliferation

Inhibition of LXR signaling by SULT2B1b promotes liver regeneration after partial hepatectomy in mouse models of nonalcoholic fatty liver disease

2020 ◽  
Vol 319 (1) ◽  
pp. G87-G96
Author(s):  
Xin Zhang ◽  
Yuyin Xu ◽  
Qianming Bai ◽  
Xiaobo Li ◽  
Jing Han ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Liver Regeneration ◽  
Nonalcoholic Fatty Liver Disease ◽  
Mouse Models ◽  
Partial Hepatectomy ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Triglyceride Accumulation ◽  
First Time

This study demonstrates for the first time that hydroxysteroid sulfotransferase 2B1b (SULT2B1b) overexpression promotes the regeneration of fatty liver after partial hepatectomy in mice with nonalcoholic fatty liver disease, while reducing triglyceride accumulation in the regenerative fatty liver. Liver X receptor signaling may be crucial in the SULT2B1b-mediated regeneration of fatty liver. Thus, SULT2B1b may be a potential target for treating hepatic steatosis-related liver regeneration disorders.

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