scholarly journals Promoter methylation ofp16associated withHelicobacter pyloriinfection in precancerous gastric lesions: A population-based study

2009 ◽  
Vol 124 (2) ◽  
pp. 434-439 ◽  
Author(s):  
Cai-Xuan Dong ◽  
Da-Jun Deng ◽  
Kai-Feng Pan ◽  
Lian Zhang ◽  
Yang Zhang ◽  
...  
Keyword(s):  
Promoter Methylation ◽  
Population Based ◽  
Gastric Lesions ◽  
Population Based Study ◽  
Precancerous Gastric Lesions

scholarly journals Sex Disparities in MGMT Promoter Methylation and Survival in Glioblastoma: Further Evidence from Clinical Cohorts

2021 ◽  
Vol 10 (4) ◽  
pp. 556
Author(s):  
Anja Smits ◽  
Malgorzata Lysiak ◽  
Andreas Magnusson ◽  
Johan Rosell ◽  
Peter Söderkvist ◽  
...  
Keyword(s):  
Promoter Methylation ◽  
Methylation Status ◽  
Population Based ◽  
Mgmt Promoter Methylation ◽  
The Other ◽  
Population Based Study ◽  
Original Analysis ◽  
Mgmt Promoter ◽  
Sex Disparities ◽  
Mgmt Promoter Methylation Status

Introduction: Recent studies suggest an overrepresentation of MGMT promoter methylated tumors in females with IDHwt glioblastoma (GBM) compared to males, with a subsequent better response to alkylating treatment. Methods: To reveal sex-bound associations that may have gone unnoticed in the original analysis, we re-analyzed two previously published clinical cohorts. One was the multicenter Nordic trial of elderly patients with GBM, randomizing patients into three different treatment arms, including 203 cases with known MGMT promoter methylation status. The other was a population-based study of 179 patients with IDHwt GBM, receiving concomittant radiotherapy and chemotherapy with temozolomide. Cohorts were stratified by sex to test the hypothesis that female sex in combination with MGMT promoter methylation constitutes a subgroup with more favorable outcome. Results: There was a significantly larger proportion of MGMT promoter methylation and better outcome for female patients with MGMT promoter methylated tumors. Results were confirmed in 257 TCGA-derived IDHwt GBM with known sex and MGMT status. Conclusions: These results confirm that patient sex in combination with MGMT promoter methylation is a key determinant in GBM to be considered prior to treatment decisions. Our study also illustrates the need for stratification to identify such sex-bound associations.

Significance of PTEN alterations in endometrial carcinoma: A population-based study of mutations, promoter methylation and PTEN protein expression

2004 ◽  
Author(s):  
Helga Salvesen ◽  
Ingunn Stefansson ◽  
Ellen Kretzschmar ◽  
Paula Gruber ◽  
Nicola MacDonald ◽  
...  
Keyword(s):  
Protein Expression ◽  
Endometrial Carcinoma ◽  
Promoter Methylation ◽  
Population Based ◽  
Population Based Study ◽  
Pten Protein

Promoter Methylation and Polymorphisms of the MGMT Gene in Glioblastomas: A Population-Based Study

2009 ◽  
Vol 32 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Izabela Zawlik ◽  
Salvatore Vaccarella ◽  
Daisuke Kita ◽  
Michel Mittelbronn ◽  
Silvia Franceschi ◽  
...  
Keyword(s):  
Promoter Methylation ◽  
Population Based ◽  
Population Based Study ◽  
I Gene

Abstract 4942: The role of one-carbon metabolism in global and promoter methylation of breast cancer in a population-based study

2010 ◽  
Author(s):  
Xinran Xu ◽  
Marilie D. Gammon ◽  
Yujing Zhang ◽  
Yoo H. Cho ◽  
James G. Wetmur ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Promoter Methylation ◽  
Carbon Metabolism ◽  
Population Based ◽  
Population Based Study ◽  
One Carbon Metabolism

scholarly journals Polycyclic aromatic hydrocarbon (PAH)–DNA adducts and breast cancer: modification by gene promoter methylation in a population-based study

2015 ◽  
Vol 26 (12) ◽  
pp. 1791-1802 ◽  
Author(s):  
Alexandra J. White ◽  
Jia Chen ◽  
Lauren E. McCullough ◽  
Xinran Xu ◽  
Yoon Hee Cho ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Dna Adducts ◽  
Promoter Methylation ◽  
Gene Promoter ◽  
Population Based ◽  
Population Based Study ◽  
Polycyclic Aromatic

Promoter methylation of MGMT in oral carcinoma: A population-based study and meta-analysis

2017 ◽  
Vol 80 ◽  
pp. 197-208 ◽  
Author(s):  
Chinchu Jayaprakash ◽  
Raghu Radhakrishnan ◽  
Satadru Ray ◽  
Kapaettu Satyamoorthy
Keyword(s):  
Promoter Methylation ◽  
Meta Analysis ◽  
Population Based ◽  
Oral Carcinoma ◽  
Population Based Study

Risk of fracture in Crohn's disease: A population-based study

2001 ◽  
Vol 120 (5) ◽  
pp. A628-A628
Author(s):  
E LOFTUSJR ◽  
C CROWSON ◽  
W SANDBORN ◽  
W TREAMINE ◽  
W OFALLON ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Population Based ◽  
Population Based Study ◽  
Risk Of Fracture

264: Population-Based Study of Renal Cell Carcinoma and Prostate Cancer in the Same Patient

2005 ◽  
Vol 173 (4S) ◽  
pp. 73-73 ◽  
Author(s):  
Daniel A. Barocas ◽  
Farhang Rabbani ◽  
Douglas S. Scherr ◽  
E. Darracott Vaughan
Keyword(s):  
Prostate Cancer ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Population Based ◽  
Population Based Study
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