scholarly journals Expression and role of adrenomedullin in renal tumors and value of its mRNA levels as prognostic factor in clear-cell renal carcinoma

2009 ◽  
Vol 125 (10) ◽  
pp. 2307-2315 ◽  
Author(s):  
Jean-Laurent Deville ◽  
Catherine Bartoli ◽  
Caroline Berenguer ◽  
Samantha Fernandez-Sauze ◽  
Itidal Kaafarani ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Renal Tumors ◽  
Mrna Levels ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma

The role of STAT3 protein as a prognostic factor in the clear cell renal carcinoma. Systematic review

2019 ◽  
Vol 43 (3) ◽  
pp. 118-123
Author(s):  
D. Lorente ◽  
E. Trilla ◽  
A. Meseguer ◽  
J. Arevalo ◽  
S. Nemours ◽  
...  
Keyword(s):  
Systematic Review ◽  
Prognostic Factor ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma

MP16-01 ROLE OF FGFR4 IN CLEAR CELL RENAL CARCINOMA AND ITS POTENTIAL AS A NEW THERAPEUTIC TARGET

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Takafumi Narisawa* ◽  
Sei Naito ◽  
Hiromi Ito ◽  
Toshihiko Sakurai ◽  
Osamu Ichiyanagi ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma

Analysis of the nuclear expression of pSer727-STAT3 as a prognostic factor in patients with clear cell renal carcinoma

2020 ◽  
Vol 44 (4) ◽  
pp. 245-250
Author(s):  
D. Lorente ◽  
J. Arevalo ◽  
M.T. Salcedo ◽  
E. Trilla ◽  
I. de Torres ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Nuclear Expression ◽  
Cell Renal Carcinoma

Expression and Proliferation-Promoting Role of Lymphoid Enhancer-Binding Factor 1 in Human Clear Cell Renal Carcinoma

2014 ◽  
Vol 32 (7) ◽  
pp. 368-374 ◽  
Author(s):  
Donghao Shang ◽  
Rumei Bi ◽  
Tiandong Han ◽  
Daye Wang ◽  
Ye Tian ◽  
...  
Keyword(s):  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Binding Factor ◽  
Cell Renal Carcinoma

scholarly journals High expression level of MMP9 is associated with poor prognosis in patients with clear cell renal carcinoma

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5050 ◽  
Author(s):  
Haitao Niu ◽  
Feng Li ◽  
Qingshui Wang ◽  
Zhoujie Ye ◽  
Qi Chen ◽  
...  
Keyword(s):  
Renal Carcinoma ◽  
Clear Cell ◽  
Gene Expression Omnibus ◽  
The Cancer Genome Atlas ◽  
Expression Level ◽  
Mrna Levels ◽  
Clear Cell Renal Carcinoma ◽  
Protein Levels ◽  
Mmp9 Expression ◽  
Cell Renal Carcinoma

Matrix metallopeptidase 9 (MMP9) was found to be associated with tumor aggressiveness. In this study, we focused on the correlation between MMP9 expression and clear cell renal carcinoma (ccRCC). Through the Gene Expression Omnibus (GEO) database, the Cancer Genome Atlas (TCGA) database and immunohistochemical (IHC) staining, we observed that compared with adjacent normal renal tissues, in ccRCC tissues the mRNA and protein levels of MMP9 were enhanced, and the mRNA levels of GTP-binding protein smg p21B(RAP1B), B rapidly accelerated fibrosarcoma (RAF), methyl ethyl ketone2 (MEK2), extracellular regulated protein kinases1 (ERK1), ERK2, v-ets avian erythroblastosis virus E26 oncogene homolog1 (ETS1) and ETS2 also increased. The Kaplan–Meier survival analysis suggested that high MMP9 expression was an unfavorable prognostic biomarker for ccRCC patients. Our results indicated that the increased expression level of MMP9 in ccRCC may be due to the activation of the Mitogen-activated protein kinases (MAPK)/ERK signaling pathway, and MMP9 may be an attractive target for ccRCC therapy.

scholarly journals Clear - cell renal carcinoma: review of literature in pediatric population / Carcinoma renal de células-claras: revisão bibliográfica na população pediátrica

2020 ◽  
Vol 65 (1) ◽  
pp. 1
Author(s):  
Fernanda Monteiro Orellana ◽  
Pablo Leonardo Traete ◽  
Victor Notari de Campos ◽  
Alan Rechamberg Ziroldo ◽  
Luis Gustavo Morato de Toledo
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Pediatric Population ◽  
Renal Tumors ◽  
Clear Cell Renal Carcinoma ◽  
Pubmed Database ◽  
Cell Renal Carcinoma

ABSTRACT:Introduction: The first reports of renal tumors originated from the renal tubule epithelium date from 1855, Robin, and 1867, Waldeyer. However, at the same era, some pathologists wrong believed these tumors were originated from adrenal gland tissues due to the fat content of the tumor (hypernephroid tumor theory - origin above the kidney, 1894). The first diagnostic test for renal tumor was excretory urography. Over the years, with the emergence of ultrasonography (US), it has been replaced. Nowadays, after the US screening, all renal lesions should be evaluated, in a complementary way, with computed tomography (CT) - gold standard - in the pre-contrast, arterial, portal, nephrographic phases. This is necessary to characterize the presence of enhancement after contrast. A kidney injury that enhances more than 15 Housfield units (UH) is suspected of kidney cell cancer. There are different subtypes of renal tumors derived from various sites of the nephron. Clear cell Renal Cell Carcinoma (RCC) is one of the subtypes that originates from the renal cortex. It is a rare tumor in children. Objective: The aim of this chapter is to review de incidence, pathology, diagnosis and treatment in clear-cell renal carcinoma in pediatric population. Methods: The authors performed a literary review about clear-cell renal carcinoma in pediatric population using Pubmed Database and Campbell-Walsh Urology as source search.Keywords: Renal cell carcinoma, Tumor, Pediatrics, Kidney, Nefrectomy ResumoRESUMO:Introdução: Os primeiros relatos de tumores renais originados do epitélio do túbulo renal datam de 1855, Robin, e 1867, Waldeyer. Contudo, na mesma época, alguns patologistas acreditavam erroneamente que esses tumores provinham dos tecidos das glândulas supra-renais, devido ao teor de gordura do tumor (hypernephroid tumor theory – origem acima do rim, 1894). O primeiro teste diagnóstico para tumor renal foi a urografia excretora. Ao longo dos anos, com o surgimento da ultrassonografia, esse teste foi substituído. Atualmente, após a leitura da ultrassonografia, todas as lesões renais devem ser avaliadas, de forma complementar, com tomografia computadorizada (TC) – padrão ouro – nas fases pré-contraste, arterial, porta e nefrográfica. Isso é necessário para caracterizar a presença de melhora após contraste. Uma lesão renal que aumenta mais de 15 unidades Housfield (UH) é suspeita de câncer de células renais. Existem diferentes subtipos de tumores derivados de vários locais do néfron. O carcinoma de células renais de células claras (CCR) é um dos subtipos originários do córtex renal. É um tumor raro em crianças. Objetivo: O objetivo deste capítulo é revisar a incidência, a patologia, o diagnóstico e o tratamento do CCR na população pediátrica. Método: Os autores realizaram uma revisão literária sobre carcinoma renal de células claras em população pediátrica usando a base de dados PubMed e o livro Campbell-Walsh de Urologia como fonte de pesquisa.Palavras chave: Carcinoma de células renais, Tumor, Pediatria, Rim, Nefrectomia

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