scholarly journals Role of transforming growth factor-  in von Hippel- Lindau (VHL)-/- clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis

2001 ◽  
Vol 98 (4) ◽  
pp. 1387-1392 ◽  
Author(s):  
N. de Paulsen ◽  
A. Brychzy ◽  
M.-C. Fournier ◽  
R. D. Klausner ◽  
J. R. Gnarra ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Renal Carcinoma ◽  
Transforming Growth Factor ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Clear Cell Renal Carcinoma ◽  
Von Hippel Lindau ◽  
Cell Renal Carcinoma

scholarly journals Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2α in Clear Cell Renal Carcinoma

2010 ◽  
Vol 78 (6) ◽  
pp. 1072-1078 ◽  
Author(s):  
Hye-Sik Kong ◽  
Sunmin Lee ◽  
Kristin Beebe ◽  
Bradley Scroggins ◽  
Gopal Gupta ◽  
...  
Keyword(s):  
Renal Carcinoma ◽  
Clear Cell ◽  
Hypoxia Inducible Factor ◽  
Clear Cell Renal Carcinoma ◽  
Von Hippel Lindau ◽  
Cell Renal Carcinoma

scholarly journals pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Javier Sevilla-Montero ◽  
Raquel Bienes-Martínez ◽  
David Labrousse-Arias ◽  
Esther Fuertes-Yebra ◽  
Ángel Ordóñez ◽  
...  
Keyword(s):  
Cell Lines ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Clear Cell Renal Carcinoma ◽  
Carcinoma Cell Lines ◽  
Thrombospondin 1 ◽  
Cell Renal Carcinoma

Treatment of Metastatic Renal Cell Carcinoma With a Combination of Bevacizumab and Erlotinib

2005 ◽  
Vol 23 (31) ◽  
pp. 7889-7896 ◽  
Author(s):  
John D. Hainsworth ◽  
Jeffrey A. Sosman ◽  
David R. Spigel ◽  
Donna L. Edwards ◽  
Cara Baughman ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Skin Rash ◽  
Renal Cell ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Targeted Agents ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma

Purpose To evaluate the efficacy and toxicity of combined treatment with two targeted agents, an antibody against vascular endothelial growth factor (bevacizumab) and an epidermal growth factor receptor tyrosine kinase inhibitor (erlotinib), in the treatment of patients with metastatic clear-cell renal carcinoma. Patients and Methods Sixty-three patients with metastatic clear-cell renal carcinoma were treated with bevacizumab 10 mg/kg intravenously every 2 weeks and erlotinib 150 mg orally daily. Patients were reevaluated after 8 weeks of treatment; patients who responded continued treatment until they experienced tumor progression. Results Fifteen (25%) of 59 assessable patients (95% CI, 16% to 37%) had objective responses to treatment, and an additional 36 patients (61%) had stable disease after 8 weeks of treatment. Only eight patients' (14%) disease had progressed at this time point. The median and 1-year progression-free survivals were 11 months and 43%, respectively. After a median follow-up of 15 months, median survival has not been reached; survival at 18 months was 60%. Treatment was generally well tolerated; only two patients discontinued treatment because of toxicity (skin rash). Grade 1/2 skin rash and diarrhea were the most frequent treatment-related toxicities. Conclusion The combination of bevacizumab and erlotinib is an effective and well-tolerated treatment for patients with advanced renal cell carcinoma. The efficacy of these two drugs in combination suggests that targeting of separate pathways critical to tumor growth and dissemination may achieve results superior to either drug as a single agent. Additional development of this and other combinations of targeted agents is warranted.

MP16-01 ROLE OF FGFR4 IN CLEAR CELL RENAL CARCINOMA AND ITS POTENTIAL AS A NEW THERAPEUTIC TARGET

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Takafumi Narisawa* ◽  
Sei Naito ◽  
Hiromi Ito ◽  
Toshihiko Sakurai ◽  
Osamu Ichiyanagi ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma
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