Prognostic significance of cathepsin-D expression in node-positive breast carcinoma: An immunohistochemical study

1993 ◽  
Vol 55 (3) ◽  
pp. 429-435 ◽  
Author(s):  
Bernard Tětu ◽  
Chantal C??té ◽  
Sonia Brisson ◽  
Nancy Roberge ◽  
Jacques Brisson ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Cathepsin D ◽  
Immunohistochemical Study ◽  
Prognostic Significance ◽  
Node Positive

Clinical Significance of Cathepsin D Concentration in Tumor Cytosol of Primary Breast Cancer

2005 ◽  
Vol 20 (2) ◽  
pp. 103-111 ◽  
Author(s):  
J. Rodríguez ◽  
J. Vízquez ◽  
M.D. Corte ◽  
M. Lamelas ◽  
M. Bongera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Primary Breast Cancer ◽  
Cathepsin D ◽  
Prognostic Significance ◽  
Immunoradiometric Assay ◽  
Breast Cancer Patients ◽  
Node Positive ◽  
Wide Range ◽  
Cause Specific Survival

Background Cathepsin D is the proteolytic enzyme most frequently implicated as a prognostic factor in primary breast cancer. In the present study we evaluated by means of an immunoradiometric assay the tumor content of this protease in primary breast cancer, its relationship with tumor-related clinical and pathological parameters, and its prognostic significance in a large series of breast cancer patients. Method The study comprised 1033 women with histologically established invasive breast cancer. Cathepsin D was measured in cytosol samples by means of an immunoradiometric assay to determine the total amount of cathepsin D (52 kDa, 48 kDa and 34 kDa). Evaluation of relapse-free survival and cause-specific survival was performed in the group of 1003 patients without evidence of metastasis at the time of initial diagnosis. The median follow-up of the patients who were free of recurrence was 54 months. Results Cathepsin D levels showed a wide range among the studied tumors (n=1033; median (range) 41 (0.9–2504) pmol/mg protein). Statistical analysis showed that the median cathepsin D levels were considerably higher in large tumors (T2–4) than in smaller ones (T1) (p=0.017), as well as in node-positive than in node-negative tumors (p=0.004). Cathepsin D levels were also higher in ductal tumors than in the other histological types (p=0.001), as well as in moderately or poorly differentiated tumors (p<0.001). Likewise, the median value of the protease was significantly higher in ER or PgR-positive tumors than in hormone receptor-negative ones (p=0.011 and p=0.004, respectively), as well as in aneuploid tumors than in diploid tumors (p=0.029). Multivariate analysis demonstrated that elevated cathepsin D levels (>59 pmol/mg protein) were notably associated with a shorter cause-specific survival in the whole group of patients with breast cancer, as well as in the subgroup of node-positive patients (p<0.05). Conclusions This study suggests that elevated intratumoral cathepsin D levels may identify a subset of node-positive breast cancer patients showing a high probability of earlier death.

scholarly journals Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study

Cancer ◽  
1990 ◽  
Vol 65 (2) ◽  
pp. 265-271 ◽  
Author(s):  
J. A. Henry ◽  
Anne L. McCarthy ◽  
B. Angus ◽  
B. R. Westley ◽  
Felicity E. B. May ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cathepsin D ◽  
Immunohistochemical Study ◽  
Prognostic Significance

The prognostic significance of CD44s and CD44v6 expression in stage two breast carcinoma: an immunohistochemical study

2001 ◽  
Vol 27 (6) ◽  
pp. 527-531 ◽  
Author(s):  
S.F. Morris ◽  
D.M. O»Hanlon ◽  
R. McLaughlin ◽  
T. McHale ◽  
G.E. Connolly ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Immunohistochemical Study ◽  
Prognostic Significance ◽  
Cd44v6 Expression

An immunohistochemical study of p21 and p53 expression in primary node-positive breast carcinoma

2002 ◽  
Vol 28 (2) ◽  
pp. 103-107 ◽  
Author(s):  
D.M. O»Hanlon ◽  
M. Kiely ◽  
M. MacConmara ◽  
R. Al-Azzawi ◽  
Y. Connolly ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Immunohistochemical Study ◽  
P53 Expression ◽  
Node Positive

scholarly journals Prognostic significance of phosphorylated P38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinoma

Cancer ◽  
2004 ◽  
Vol 100 (3) ◽  
pp. 499-506 ◽  
Author(s):  
Francisco J. Esteva ◽  
Aysegul A. Sahin ◽  
Terry L. Smith ◽  
Ying Yang ◽  
Lajos Pusztai ◽  
...  
Keyword(s):  
Lymph Node ◽  
Protein Kinase ◽  
Breast Carcinoma ◽  
Prognostic Significance ◽  
Mitogen Activated Protein Kinase ◽  
Node Positive ◽  
Mitogen Activated Protein ◽  
Her 2 ◽  
Lymph Node Positive
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