Prognostic significance of total number of nodes removed, negative nodes removed, and ratio of positive nodes to removed nodes in node positive breast carcinoma

2006 ◽  
Vol 32 (10) ◽  
pp. 1082-1088 ◽  
Author(s):  
B. Kuru
Keyword(s):  
Breast Carcinoma ◽  
Prognostic Significance ◽  
Node Positive

Prognostic significance of cathepsin-D expression in node-positive breast carcinoma: An immunohistochemical study

1993 ◽  
Vol 55 (3) ◽  
pp. 429-435 ◽  
Author(s):  
Bernard Tětu ◽  
Chantal C??té ◽  
Sonia Brisson ◽  
Nancy Roberge ◽  
Jacques Brisson ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Cathepsin D ◽  
Immunohistochemical Study ◽  
Prognostic Significance ◽  
Node Positive

scholarly journals Prognostic significance of phosphorylated P38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinoma

Cancer ◽  
2004 ◽  
Vol 100 (3) ◽  
pp. 499-506 ◽  
Author(s):  
Francisco J. Esteva ◽  
Aysegul A. Sahin ◽  
Terry L. Smith ◽  
Ying Yang ◽  
Lajos Pusztai ◽  
...  
Keyword(s):  
Lymph Node ◽  
Protein Kinase ◽  
Breast Carcinoma ◽  
Prognostic Significance ◽  
Mitogen Activated Protein Kinase ◽  
Node Positive ◽  
Mitogen Activated Protein ◽  
Her 2 ◽  
Lymph Node Positive

Breast carcinoma in young females below the age of 35 years - histopathological and prognostic significance

1970 ◽  
Vol 2 (3) ◽  
pp. 198-202
Author(s):  
D Ghartimagar ◽  
A Ghosh ◽  
OP Talwar ◽  
R Narasimhan
Keyword(s):  
Breast Carcinoma ◽  
Young Women ◽  
Early Stage ◽  
Prognostic Significance ◽  
Age Group ◽  
Breast Cancers ◽  
Young Females ◽  
Younger Age ◽  
Grade 3 ◽  
Group Grade

Background: Breast cancers rarely occur in young women but are known to have more aggressive behaviors and poorer outcome. We here compare the significance of breast carcinoma in female below the age of 35 to the age over 35 whose specimens were submitted to Manipal teaching hospital, Pokhara. Materials and Methods: All cases of mastectomy with carcinoma from January 2000 to September 2011 were included in the study. Clinical and histopathological datas of all cases were reviewed and collated. Results: A total of 148 mastectomy specimens were received, among which, 23 cases (16%) were below 35 years; whereas 125 cases (84%) were above 35 years of age. In both groups, Stage II was the commonest stage but stage III was much more common in older group (33% versus 9%) and stage I was more common in younger age group (39% versus 27%). Bloom Richardson grading showed that in the older age group, grade 1 is the commonest grade (50%) while in the younger group; grade 3 is the commonest (39%). Patients were followed for a varying period of 6 months to 5 years. Two cases (2% of followed up cases) in older group and 3 cases (15% of followed up cases) in the younger group showed recurrence. Conclusion: Breast carcinoma in the patients younger than 35 years though presented at an early stage has higher grade tumor and poorer outcome. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6021 JPN 2012; 2(3): 198-202

Prognostic significance of apical lymph node metastasis in patients with node-positive rectal cancer

2012 ◽  
Vol 15 (1) ◽  
pp. e13-e20 ◽  
Author(s):  
J. Peng ◽  
H. Wu ◽  
X. Li ◽  
W. Sheng ◽  
D. Huang ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Prognostic Significance ◽  
Node Metastasis ◽  
Node Positive

Lymph Node Ratio May Be Supplementary to TNM Nodal Classification in Node-positive Breast Carcinoma Based on the Results of 2,151 Patients

2013 ◽  
Vol 37 (6) ◽  
pp. 1241-1248 ◽  
Author(s):  
Nüvit Duraker ◽  
Bakir Batı ◽  
Zeynep Civelek Çaynak ◽  
Davut Demir
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Lymph Node Ratio ◽  
Node Positive ◽  
Node Ratio

Oncogenes and Male Breast Carcinoma: c-erbB-2 and p53 Coexpression Predicts a Poor Survival

2000 ◽  
Vol 18 (16) ◽  
pp. 2948-2956 ◽  
Author(s):  
Achille Pich ◽  
Elena Margaria ◽  
Luigi Chiusa
Keyword(s):  
Breast Carcinoma ◽  
Prognostic Value ◽  
Ductal Carcinoma ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Male Breast ◽  
Male Breast Carcinoma ◽  
P53 Immunoreactivity ◽  
Mib 1

PURPOSE: To investigate the prognostic value of biomarkers in male breast carcinoma (MBC). PATIENTS AND METHODS: Fifty patients (mean age, 62.2 years) with invasive ductal carcinoma were retrospectively studied. All patients received surgery; 35 had adjuvant postoperative therapy. The median follow-up was 59 months (range, 1 to 230 months). c-myc, c-erbB-2, p53, and bcl-2 proteins were immunohistochemically detected on sections from formalin-fixed, paraffin-embedded tissues using 9E11, CB11, DO7, and bcl-2 124 monoclonal antibodies (mAbs). Estrogen, progesterone, and androgen receptors were detected using specific mAbs. Cell proliferation was assessed by MIB-1 mAb. RESULTS: In univariate analysis, c-myc, c-erbB-2, and p53 protein overexpression was significantly correlated with prognosis. The median survival was 107 months for c-myc–negative and 52 months for c-myc–positive patients (P = .01), 96 months for c-erbB-2–negative and 39 months for c-erbB-2–positive patients (P = .02), and 100 months for p53-negative and 33 months for p53-positive patients (P = .0008). Tumor histologic grade (P = .01), tumor size (P = .02), patient age at diagnosis (P = .03), and MIB-1 scores (P = .0004) also had prognostic value. In multivariate analysis, only c-erbB-2 and p53 immunoreactivity retained independent prognostic significance. All nine patients who did not express c-erbB-2 and p53 proteins were alive after 58 months, whereas none of the 14 patients expressing both proteins survived at 61 months follow-up (P = .0002). CONCLUSION: Overexpression of c-myc, c-erbB-2, and p53 proteins may be regarded as an additional prognostic factor in MBC. The combination of c-erbB-2 and p53 immunoreactivity can stratify patients into different risk groups.

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