Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models

Abstract 924: The androgen receptor antagonist darolutamide shows strong antitumor efficacy in patient- and cell line-derived xenograft prostate cancer models

10.1158/1538-7445.am2019-924 ◽

2019 ◽

Author(s):

Pascale Lejeune ◽

Antje Wengner ◽

Simon J. Baumgart ◽

Ekaterina Nevedomskaya ◽

Eva Corey ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Cell Line ◽

Antitumor Efficacy ◽

Abstract A028: In vitro and in vivo efficacy of the androgen receptor antagonist darolutamide in prostate cancer models

10.1158/1538-7445.prca2017-a028 ◽

2018 ◽

Author(s):

Tatsuo Sugawara ◽

Simon J. Baumgart ◽

Kristin Reichert ◽

Pascale Lejeune ◽

Bernard Haendler

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Receptor Antagonist ◽

In Vivo Efficacy ◽

Abstract 924: The androgen receptor antagonist darolutamide shows strong antitumor efficacy in patient- and cell line-derived xenograft prostate cancer models

10.1158/1538-7445.sabcs18-924 ◽

2019 ◽

Author(s):

Pascale Lejeune ◽

Antje Wengner ◽

Simon J. Baumgart ◽

Ekaterina Nevedomskaya ◽

Eva Corey ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Cell Line ◽

Antitumor Efficacy ◽

Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC)

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01563 ◽

2021 ◽

Vol 64 (2) ◽

pp. 909-924 ◽

Cited By ~ 1

Author(s):

Zhuming Zhang ◽

Peter J. Connolly ◽

Heng Keang Lim ◽

Vineet Pande ◽

Lieven Meerpoel ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Clinical Stage ◽

Wild Type ◽

Castration Resistant

The androgen receptor antagonist enzalutamide induces apoptosis, dysregulates the heat shock protein system, and diminishes the androgen receptor and estrogen receptor β1 expression in prostate cancer cells

Journal of Cellular Biochemistry ◽

10.1002/jcb.28929 ◽

2019 ◽

Vol 120 (10) ◽

pp. 16711-16722

Author(s):

Alexander Abazid ◽

Benedikt Martin ◽

Anja Choinowski ◽

Rhiannon V. McNeill ◽

Lars‐Ove Brandenburg ◽

...

Keyword(s):

Prostate Cancer ◽

Estrogen Receptor ◽

Androgen Receptor ◽

Heat Shock ◽

Heat Shock Protein ◽

Receptor Antagonist ◽

Cancer Cells ◽

Prostate Cancer Cells ◽

Protein System ◽

Androgen Receptor Antagonist

Suberoylanilide hydroxamic acid (vorinostat) represses androgen receptor expression and acts synergistically with an androgen receptor antagonist to inhibit prostate cancer cell proliferation

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-06-0144 ◽

2007 ◽

Vol 6 (1) ◽

pp. 51-60 ◽

Cited By ~ 73

Author(s):

Deborah L. Marrocco ◽

Wayne D. Tilley ◽

Tina Bianco-Miotto ◽

Andreas Evdokiou ◽

Howard I. Scher ◽

...

Keyword(s):

Prostate Cancer ◽

Cell Proliferation ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Hydroxamic Acid ◽

Prostate Cancer Cell ◽

Receptor Expression ◽

Suberoylanilide Hydroxamic Acid ◽

Cancer Cell Proliferation ◽

Androgen Receptor Antagonist

Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509), a Potent Androgen Receptor Antagonist, in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort

European Urology ◽

10.1016/j.eururo.2016.04.023 ◽

2016 ◽

Vol 70 (6) ◽

pp. 963-970 ◽

Cited By ~ 55

Author(s):

Matthew R. Smith ◽

Emmanuel S. Antonarakis ◽

Charles J. Ryan ◽

William R. Berry ◽

Neal D. Shore ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

High Risk ◽

Antitumor Activity ◽

Receptor Antagonist ◽

Phase 2 ◽

Castration Resistant ◽

Phase 2 Study

Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer

ACS Medicinal Chemistry Letters ◽

10.1021/acsmedchemlett.5b00173 ◽

2015 ◽

Vol 6 (8) ◽

pp. 908-912 ◽

Cited By ~ 11

Author(s):

Aaron Balog ◽

Richard Rampulla ◽

Gregory S. Martin ◽

Stanley R. Krystek ◽

Ricardo Attar ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Androgen Receptor Antagonist

Phospholipase C (PLC)ε Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line

Medical Science Monitor ◽

10.12659/msm.915828 ◽

2019 ◽

Vol 25 ◽

pp. 4438-4449 ◽

Cited By ~ 1

Author(s):

Mengjuan Yuan ◽

Yingying Gao ◽

Luo Li ◽

Wei Sun ◽

Honglin Cheng ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Prostate Cancer Cell ◽

Cancer Cell Line ◽

Prostate Cancer Cell Line ◽

Castration Resistant ◽

Morphogenetic Protein

Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer

Oncotarget ◽

10.18632/oncotarget.8456 ◽

2016 ◽

Vol 7 (18) ◽

pp. 26259-26274 ◽

Cited By ~ 38

Author(s):

Steven Kregel ◽

James L. Chen ◽

Westin Tom ◽

Venkatesh Krishnan ◽

Jacob Kach ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Second Generation ◽

Acquired Resistance ◽

Castration Resistant