scholarly journals Intratesticular Testosterone Concentrations Comparable With Serum Levels Are Not Sufficient to Maintain Normal Sperm Production in Men Receiving a Hormonal Contraceptive Regimen

2004 ◽  
Vol 25 (6) ◽  
pp. 931-938 ◽  
Author(s):  
Andrea D. Coviello ◽  
William J. Bremner ◽  
Alvin M. Matsumoto ◽  
Karen L. Herbst ◽  
John K. Amory ◽  
...  
Keyword(s):  
Serum Levels ◽  
Hormonal Contraceptive ◽  
Sperm Production ◽  
Normal Sperm

SERUM GONADOTROPHINS, TESTOSTERONE AND SPERMATOGENESIS IN SUBFERTILE MEN

1977 ◽  
Vol 86 (3) ◽  
pp. 651-658 ◽  
Author(s):  
J. H. Aafjes ◽  
J. C. M. van der Vijver ◽  
R. Docter ◽  
P. E. Schenck
Keyword(s):  
Partial Correlation ◽  
Sperm Count ◽  
Correlation Coefficients ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
The Other ◽  
Sperm Production ◽  
Positive Correlation ◽  
Natural Logarithm ◽  
Biopsy Score

ABSTRACT In 210 subfertile men there existed a significant positive correlation between serum FSH and LH (0.41). No correlation was observed between the gonadotrophin levels and testosterone. In contrast to this FSH as well as LH were negatively correlated with the natural logarithm (In) of the sperm count/ml ejaculate (−0.44 and −0.18, respectively). When the positive correlation which existed between FSH and LH was used to calculate partial correlation coefficients, the coefficient between FSH and ln sperm count did hardly change (−0.41) the coefficient between LH and ln sperm count on the other hand became insignificant (−0.05). This suggests that spermatogenesis influences FSH serum levels in subfertile men by a decreased suppression when sperm production is diminished. Testicular biopsies taken from 97 of these patients were used to determine biopsy scores. These scores showed a significant negative correlation with FSH (−0.34) and a positive one with ln sperm count/ml ejaculate (0.45). Interestingly the biopsy score of 16 patients who fertilized their wives, was found to be higher compared with the score of the other patients who did not fertilize. The number of sperm/ml ejaculate and the FSH values of these 2 groups of biopsied patients were, however, not significantly different. This leads to the conclusion that the biopsy score is a better parameter for the evaluation of oligospermic men than either sperm count or FSH serum values.

Genetic Interaction of Hils1 with Tnp1 Is Essential for Normal Sperm Production and Male Fertility.

2009 ◽  
Vol 81 (Suppl_1) ◽  
pp. 462-462 ◽  
Author(s):  
Qiuxia Wu ◽  
Huili Zheng ◽  
Larisa Wiggins ◽  
Christopher von Bartheld ◽  
Ming Zhao ◽  
...  
Keyword(s):  
Male Fertility ◽  
Genetic Interaction ◽  
Sperm Production ◽  
Normal Sperm

scholarly journals Follicle-Stimulating Hormone (FSH) Action on Spermatogenesis: A Focus on Physiological and Therapeutic Roles

2020 ◽  
Vol 9 (4) ◽  
pp. 1014 ◽  
Author(s):  
Daniele Santi ◽  
Pascale Crépieux ◽  
Eric Reiter ◽  
Giorgia Spaggiari ◽  
Giulia Brigante ◽  
...  
Keyword(s):  
Hypogonadotropic Hypogonadism ◽  
Follicle Stimulating Hormone ◽  
Genetic Regulation ◽  
Physiological Role ◽  
Serum Levels ◽  
Human Reproduction ◽  
Sperm Production ◽  
Female Reproduction ◽  
Physiological Control ◽  
Stimulating Hormone

Background: Human reproduction is regulated by the combined action of the follicle-stimulating hormone (FSH) and the luteinizing hormone (LH) on the gonads. Although FSH is largely used in female reproduction, in particular in women attending assisted reproductive techniques to stimulate multi-follicular growth, its efficacy in men with idiopathic infertility is not clearly demonstrated. Indeed, whether FSH administration improves fertility in patients with hypogonadotropic hypogonadism, the therapeutic benefit in men presenting alterations in sperm production despite normal FSH serum levels is still unclear. In the present review, we evaluate the potential pharmacological benefits of FSH administration in clinical practice. Methods: This is a narrative review, describing the FSH physiological role in spermatogenesis and its potential therapeutic action in men. Results: The FSH role on male fertility is reviewed starting from the physiological control of spermatogenesis, throughout its mechanism of action in Sertoli cells, the genetic regulation of its action on spermatogenesis, until the therapeutic options available to improve sperm production. Conclusion: FSH administration in infertile men has potential benefits, although its action should be considered by evaluating its synergic action with testosterone, and well-controlled, powerful trials are required. Prospective studies and new compounds could be developed in the near future.

Observations on spermatogenesis, sperm phenotype, and fertility in white-tailed × mule deer hybrids and a yak × cow hybrid

1988 ◽  
Vol 66 (7) ◽  
pp. 1664-1671 ◽  
Author(s):  
William D. Wishart ◽  
Francis Hrudka ◽  
Sheila M. Schmutz ◽  
Peter F. Flood
Keyword(s):  
Sperm Morphology ◽  
Parental Species ◽  
Mule Deer ◽  
Odocoileus Hemionus ◽  
Species Interaction ◽  
The Other ◽  
Sperm Production ◽  
Histological Techniques ◽  
Normal Sperm ◽  
Testicular Differentiation

Fertility, spermatogenesis, and sperm phenotype were investigated in three hybrid deer (Odocoileus virginianus dacotensis × Odocoileus hemionus hemionus) and a yak × domestic cow hybrid (Bos mutus (grunniens) × Bos primigenius (taurus)) using histological techniques. All of the hybrids studied were infertile but varied in the degree of testicular differentiation, spermatogenic activity, and sperm production. The hybrid yak was the least developed and the white-tailed deer × F1 hybrid was the most advanced. F1 backcrossing improved spermatogenesis, output, and morphology of sperm, but not the fertility of the donor, indicating that normal sperm morphology alone does not assure fertility. Two deer hybrids that produced sperm differed in sperm phenotype from each other and from the parental species. Interaction of a Y chromosome from one species and autosomal sex-determining genes from the other species is suggested as a possible explanation of sterility in male hybrids.

scholarly journals Copy number variations of five Y chromosome genes in donkeys

2017 ◽  
Vol 60 (4) ◽  
pp. 391-397 ◽  
Author(s):  
Haoyuan Han ◽  
Xiaocheng Zhao ◽  
Xiaoting Xia ◽  
Hong Chen ◽  
Chuzhao Lei ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Copy Number ◽  
Single Copy ◽  
Copy Number Variations ◽  
Sperm Production ◽  
Specific Transcript ◽  
Normal Sperm ◽  
Copy Numbers ◽  
Qpcr Method ◽  
Male Sex

Abstract. In mammals, the Y chromosome plays a pivotal role in male sex determination and is essential for normal sperm production. A number of studies were conducted on Y chromosome genes of various species and identified single-copy and multi-copy genes. However, limited studies about donkey Y chromosome genes have been done. In this study, 263 male samples from 13 Chinese donkey breeds were collected to analyze the copy number variations (CNVs) of five Y chromosome genes using the quantitative PCR (qPCR) method. These five genes (cullin 4 B Y (CUL4BY), equus testis-specific transcript y1 (ETSTY1), equus testis-specific transcript y4 (ETSTY4), equus testis-specific transcript Y 5 (ETSTY5), and sex-determining region Y (SRY) were identified as multi-copy, whose median copy numbers (MCNs) were 5, 45, 2, and 2, and 13 with CNV ranges of 1–57, 1–227, 1–37, 1–86 and 1–152, respectively. The CNVs of these five genes were shared in different breeds. Compared to previous studies, the copy numbers of five genes showed some distinct consequences in this study. In particular, the well-known single-copy SRY gene showed CNVs in donkeys. Our results provided genetic variations of donkey Y chromosome genes.

Correlations between the Quantitative Morphology of the Human Testis and Sperm Production The Testis of Healthy Men with Normal Sperm Counts

1980 ◽  
Vol 3 (1-6) ◽  
pp. 170-176 ◽  
Author(s):  
P. A. Dop ◽  
P. H. J. Kurver ◽  
R. J. Scholtmeijer ◽  
J. P. A. Baak ◽  
J. Oort ◽  
...  
Keyword(s):  
Human Testis ◽  
Sperm Production ◽  
Quantitative Morphology ◽  
Healthy Men ◽  
Normal Sperm ◽  
Sperm Counts

Nucleolar Segregation and Chronic Methanol Intoxication

1969 ◽  
Vol 27 ◽  
pp. 360-361
Author(s):  
Julio H. Garcia ◽  
Janice P. Van Zandt
Keyword(s):  
Body Weight ◽  
Methyl Alcohol ◽  
Rhesus Monkeys ◽  
Repeated Administration ◽  
Serum Levels ◽  
Methanol Intoxication ◽  
Intragastric Tube ◽  
Nucleolar Segregation

Repeated administration of methyl alcohol to Rhesus monkeys (Maccaca mulata) by intragastric tube resulted in ultrastructural abnormalities of hepatocytes, which persisted in one animal twelve weeks after discontinuation of the methyl alcohol regime. With dosages ranging between 3.0 to 6.0 gms. of methanol per kg. of body weight, the serum levels attained within a few hours averaged approximately 475 mg. per cent.

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