Genetic Interaction of Hils1 with Tnp1 Is Essential for Normal Sperm Production and Male Fertility.

PURPOSE Because the effects of mitoxantrone on human male fertility were unknown, we determined prospectively the effects of three courses of mitoxantrone (Novantrone), vincristine (Oncovin), vinblastine, prednisone (NOVP) chemotherapy on the potential for fertility of men with Hodgkin's disease (HD). PATIENTS AND METHODS Semen analyses were performed on 58 patients with stages I-III HD before, during, and after chemotherapy and after the sperm count recovered from the effects of abdominal radiotherapy that was given after chemotherapy. RESULTS Before the initiation of treatment, 84% of the patients were normospermic. Sperm counts declined significantly within 1 month after the start of NOVP chemotherapy. In the month after chemotherapy, 38% of patients were azoospermic, 52% had counts < 1 million/ mL, and 10% had counts between 1 and 3 million/mL. Between 2.6 and 4.5 months after the completion of chemotherapy, sperm counts recovered rapidly to normospermic levels in 63% of patients. In the remaining patients who were followed up for at least 1 year after standard upper abdominal radiotherapy, counts also recovered to normospermic levels. CONCLUSION NOVP chemotherapy, like most other regimens, produced marked temporary effects or spermatogenesis. However, sperm production recovered very rapidly, within 3 to 4 months after the end of NOVP chemotherapy. This pattern was caused by killing differentiating spermatogenic cells, but there was little cytotoxicity or inhibition of stem cells from mitoxantrone or the other drugs. After the combination of NOVP plus abdominal radiotherapy, sperm counts and motility were restored in most patients to pretreatment levels, which were compatible with normal fertility.

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Observations on spermatogenesis, sperm phenotype, and fertility in white-tailed × mule deer hybrids and a yak × cow hybrid

Canadian Journal of Zoology ◽

10.1139/z88-240 ◽

1988 ◽

Vol 66 (7) ◽

pp. 1664-1671 ◽

Cited By ~ 8

Author(s):

William D. Wishart ◽

Francis Hrudka ◽

Sheila M. Schmutz ◽

Peter F. Flood

Keyword(s):

Sperm Morphology ◽

Parental Species ◽

Mule Deer ◽

Odocoileus Hemionus ◽

Species Interaction ◽

The Other ◽

Sperm Production ◽

Histological Techniques ◽

Normal Sperm ◽

Testicular Differentiation

Fertility, spermatogenesis, and sperm phenotype were investigated in three hybrid deer (Odocoileus virginianus dacotensis × Odocoileus hemionus hemionus) and a yak × domestic cow hybrid (Bos mutus (grunniens) × Bos primigenius (taurus)) using histological techniques. All of the hybrids studied were infertile but varied in the degree of testicular differentiation, spermatogenic activity, and sperm production. The hybrid yak was the least developed and the white-tailed deer × F1 hybrid was the most advanced. F1 backcrossing improved spermatogenesis, output, and morphology of sperm, but not the fertility of the donor, indicating that normal sperm morphology alone does not assure fertility. Two deer hybrids that produced sperm differed in sperm phenotype from each other and from the parental species. Interaction of a Y chromosome from one species and autosomal sex-determining genes from the other species is suggested as a possible explanation of sterility in male hybrids.

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Leucine zipper transcription factor-like 1 (LZTFL1), an intraflagellar transporter protein 27 (IFT27) associated protein, is required for normal sperm function and male fertility

Developmental Biology ◽

10.1016/j.ydbio.2021.05.006 ◽

2021 ◽

Author(s):

Qian Huang ◽

Wei Li ◽

Qi Zhou ◽

Parirokh Awasthi ◽

Caroline Cazin ◽

...

Keyword(s):

Transcription Factor ◽

Male Fertility ◽

Leucine Zipper ◽

Sperm Function ◽

Transporter Protein ◽

Normal Sperm

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254 Effects of Nutrition on Bull Fertility

Journal of Animal Science ◽

10.1093/jas/skab235.249 ◽

2021 ◽

Vol 99 (Supplement_3) ◽

pp. 136-136

Author(s):

Tom W Geary ◽

Carl R Dahlen ◽

Abigail L Zezeski

Keyword(s):

Beneficial Effect ◽

Breeding Season ◽

Male Fertility ◽

Sperm Production ◽

Creep Feeding ◽

Mineral Supplementation ◽

Bull Calves ◽

Inorganic Mineral ◽

Energy Supplements ◽

Cu And Zn

Abstract The greatest effects of nutrition on bull fertility occur by providing a relatively high plane of nutrition during calfhood when the seminiferous epithelium of the testes is developing. A high plane of nutrition from 5 to 25 weeks of age results in greater circulating gonadotropin concentrations, greater testicular volume, and greater sperm production at maturity. At this age, diet can be manipulated by creep feeding bull calves with both protein and energy supplements which could accelerate puberty and increase sperm production. Increased rate of gain in bull calves post-weaning can accelerate puberty a few weeks, but excess post-weaning gain and fat buildup in the neck of the scrotum can have detrimental effects on fertility. Considerable emphasis has been placed on specific micronutrient (especially minerals) effects on peripubertal bull fertility. Trace mineral supplementation is believed to be critical for optimal fertility and both copper (Cu) and zinc (Zn) supplementation have influenced male fertility in other species. However, there are no guidelines for recommended levels of these minerals to ensure fertility. Providing organic or complexed compared to inorganic mineral to peripubertal bulls have increased liver concentrations of mineral and in some cases, have accelerated puberty, but enhanced fertility-associated measures have not been realized. Because both Cu and Zn are present in the ejaculate, mineral needs during the breeding season may differ from the off-season. During the breeding season, bulls can lose 10 to 20% of their weight and need to re-gain this weight before the next breeding season. Divergent planes of nutrition provided to mature bulls during the off-season revealed enhanced sperm energy and stress-fighting potential with decreasing plane of nutrition. Specific mineral supplementation during the off-season in mature bulls provides no beneficial effect on fertility-associated measures. In summary, significant effects of nutrition post-weaning on bull fertility-associated measures have not been realized.

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Protein and carbohydrate intake influence sperm number and fertility in male cockroaches, but not sperm viability

Proceedings of The Royal Society B Biological Sciences ◽

10.1098/rspb.2014.2144 ◽

2015 ◽

Vol 282 (1802) ◽

pp. 20142144 ◽

Cited By ~ 41

Author(s):

Harriet Bunning ◽

James Rapkin ◽

Laurence Belcher ◽

C. Ruth Archer ◽

Kim Jensen ◽

...

Keyword(s):

Recent Work ◽

Male Fertility ◽

Nutrient Intake ◽

Sperm Viability ◽

Sperm Number ◽

Sperm Production ◽

High Intake ◽

Trade Off ◽

Numerous Species ◽

Dietary Choice

It is commonly assumed that because males produce many, tiny sperm, they are cheap to produce. Recent work, however, suggests that sperm production is not cost-free. If sperm are costly to produce, sperm number and/or viability should be influenced by diet, and this has been documented in numerous species. Yet few studies have examined the exact nutrients responsible for mediating these effects. Here, we quantify the effects of protein (P) and carbohydrate (C) intake on sperm number and viability in the cockroach Nauphoeta cinerea , as well as the consequences for male fertility. We found the intake of P and C influenced sperm number, being maximized at a high intake of diets with a P : C ratio of 1 : 2, but not sperm viability. The nutritional landscapes for male fertility and sperm number were closely aligned, suggesting that sperm number is the major determinant of male fertility in N. cinerea . Under dietary choice, males regulate nutrient intake at a P : C ratio of 1 : 4.95, which is midway between the ratios needed to maximize sperm production and pre-copulatory attractiveness in this species. This raises the possibility that males regulate nutrient intake to balance the trade-off between pre- and post-copulatory traits in this species.

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The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.251686198 ◽

2002 ◽

Vol 99 (4) ◽

pp. 2112-2117 ◽

Cited By ~ 44

Author(s):

M. J. Wishart ◽

J. E. Dixon

Keyword(s):

Binding Protein ◽

Sperm Production ◽

Normal Sperm ◽

Mrna Binding Protein ◽

Mrna Binding

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Copy number variations of five Y chromosome genes in donkeys

Archives Animal Breeding ◽

10.5194/aab-60-391-2017 ◽

2017 ◽

Vol 60 (4) ◽

pp. 391-397 ◽

Cited By ~ 1

Author(s):

Haoyuan Han ◽

Xiaocheng Zhao ◽

Xiaoting Xia ◽

Hong Chen ◽

Chuzhao Lei ◽

...

Keyword(s):

Y Chromosome ◽

Copy Number ◽

Single Copy ◽

Copy Number Variations ◽

Sperm Production ◽

Specific Transcript ◽

Normal Sperm ◽

Copy Numbers ◽

Qpcr Method ◽

Male Sex

Abstract. In mammals, the Y chromosome plays a pivotal role in male sex determination and is essential for normal sperm production. A number of studies were conducted on Y chromosome genes of various species and identified single-copy and multi-copy genes. However, limited studies about donkey Y chromosome genes have been done. In this study, 263 male samples from 13 Chinese donkey breeds were collected to analyze the copy number variations (CNVs) of five Y chromosome genes using the quantitative PCR (qPCR) method. These five genes (cullin 4 B Y (CUL4BY), equus testis-specific transcript y1 (ETSTY1), equus testis-specific transcript y4 (ETSTY4), equus testis-specific transcript Y 5 (ETSTY5), and sex-determining region Y (SRY) were identified as multi-copy, whose median copy numbers (MCNs) were 5, 45, 2, and 2, and 13 with CNV ranges of 1–57, 1–227, 1–37, 1–86 and 1–152, respectively. The CNVs of these five genes were shared in different breeds. Compared to previous studies, the copy numbers of five genes showed some distinct consequences in this study. In particular, the well-known single-copy SRY gene showed CNVs in donkeys. Our results provided genetic variations of donkey Y chromosome genes.

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Suppression of spermatogenesis by exogenous testosterone

Current Pharmaceutical Design ◽

10.2174/1381612826666201207104340 ◽

2020 ◽

Vol 26 ◽

Author(s):

Ferdinando Fusco ◽

Paolo Verze ◽

Marco Capece ◽

Luigi Napolitano

Keyword(s):

Male Fertility ◽

Leydig Cells ◽

Sperm Count ◽

Sperm Concentration ◽

Seminiferous Tubules ◽

Sperm Production ◽

Long Term Effects ◽

Fertility Status ◽

Normal Spermatogenesis

: Sperm production starts from puberty in the seminiferous tubules providing for testosterone production by the Leydig cells taking place in the interstice of the testicles. Normal spermatogenesis depends on specific signalling from the hypothalamic-pituitary-gonadal axis. GnRH, FSH and LH are the main hormones involved in the production and maturation of spermatozoa. Exogenous administration of androgens influences the hypothalamic-pituitary-gonadal axis with negative feedback that may lead to partial or complete cessation of spermatogenesis by decreasing FSH and LH. Despite the fact that many trials have confirmed that exogenous testosterone affects male fertility status, evidence regarding the long-term effects of treatment is conflicting. Regarding this aspect, many studies have confirmed a return to baseline sperm concentration after testosterone treatment discontinuation, however none of them can specify how long recovery will take nor whether the sperm count is sufficient for fertility.

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Spermatogenesis, gonadal sperm reserves and fertility of rabbits fed micro doses of fumonisin

Nigerian Journal of Animal Production ◽

10.51791/njap.v34i2.1215 ◽

2021 ◽

Vol 34 (2) ◽

pp. 316-322

Author(s):

F.A. Gbore ◽

E. O. Ewuola ◽

J.T. Ogunlade ◽

K. O. Idahor ◽

A. O. Salako ◽

...

Keyword(s):

Body Weight ◽

Male Fertility ◽

Fusarium Verticillioides ◽

Sperm Storage ◽

Testis Weight ◽

Sperm Production ◽

Volume Percent ◽

Embryo Survival ◽

Short Time ◽

Tubular Diameter

The effects of micro doses of dietary fumonisin, a metabolite of Fusarium verticillioides, on spermatogenesis, gonadal sperm reserves and fertility of rabbits were studied. Relative paired testis weight; sperm production rate and sperm storage potential were not adversely affected in rabbits which were exposed to varied minute levels of dietary fumonisin of about 153-161 µg/kg body weight/day over a period of 8 weeks. The toxin also failed to exert any influence (P>0.05) on seminiferous tubular diameter and volume percent of testicular elements. Male fertility as evidenced by conception rate, litter size and embryo survival and normalcy was also not affected (P>0.05). However, the frequency of occurrence of stages II and VIII of the cycle of the seminiferous epithelium were significantly (P<0.05) influenced with increased dietary fumonisin levels. The results suggest that the ingestion of Fusarium-infected feed that would result in the liberation of about 153 µg of fumonisin/kg of body weight per day for a short time may not influence spermatogenesis, fertility in the male or the normalcy of the resulting foetuses.

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