Gene expression network related to DNA methylation and miRNA regulation during the process of aflatoxin B1‐induced malignant transformation of L02 cells

Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells

Toxicology Letters ◽

10.1016/j.toxlet.2018.03.003 ◽

2018 ◽

Vol 289 ◽

pp. 42-53 ◽

Cited By ~ 12

Author(s):

Hong-qiang Chen ◽

Ji Zhao ◽

Yan Li ◽

Li-xiong He ◽

Yu-jing Huang ◽

...

Keyword(s):

Gene Expression ◽

Dna Methylation ◽

Malignant Transformation ◽

Human Hepatocyte ◽

Gene Expression Network ◽

L02 Cells

Epigenetic Effects of IDH1/IDH2 Mutations

Blood ◽

10.1182/blood.v118.21.sci-33.sci-33 ◽

2011 ◽

Vol 118 (21) ◽

pp. SCI-33-SCI-33 ◽

Cited By ~ 1

Author(s):

Ari M. Melnick ◽

Ross L Levine ◽

Maria E Figueroa ◽

Craig B. Thompson ◽

Omar Abdel-Wahab

Keyword(s):

Gene Expression ◽

Dna Methylation ◽

Stem Cells ◽

Hematopoietic Stem Cells ◽

Malignant Transformation ◽

Covalent Modification ◽

Specific Gene ◽

Gene Promoters ◽

Loss Of Function ◽

Hematopoietic Stem

Abstract Abstract SCI-33 Epigenetic deregulation of gene expression through aberrant DNA methylation or histone modification plays an important role in the malignant transformation of hematopoietic cells. In particular, acute myeloid leukemias (AMLs) can be classified according to epigenetic signatures affecting DNA methylation or histone modifications affecting specific gene sets. Heterozygous somatic mutations in the loci encoding isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in ∼20% of AMLs and are accompanied by global DNA hypermethylation and hypermethylation and silencing of a number of specific gene promoters. IDH1/2 mutations are almost completely mutually exclusive with somatic loss-of-function mutations in TET2, which hydroxylates methylcytosine (mCpG). DNA hydroxymethylation can function as an intermediate step in mCpG demethylation. TET2 mutant de novo AMLs also display global and promoter specific hypermethylation partially overlapping with IDH1/2 mutant cases. Mutations in the IDH1/2 loci result in a neomorphic enzyme that generates the aberrant oncometabolite 2-hydroxyglutarate (2HG) using α-ketoglutarate (αKG) as a substrate. 2HG can disrupt the activity of enzymes that use αKG as a cofactor, including TET2 and the jumonji family of histone demethylases. Expression of mutant IDH isoforms inhibits TET2 hydroxymethylation and jumonji histone demethylase functions. IDH and TET2 mutant AMLs accordingly exhibit reduced levels of hydroxymethylcytosine and a trend towards increased histone methylation. Mutant IDH or TET2 loss of function causes differentiation blockade and expansion of hematopoietic stem cells and TET2 knockout results in a myeloproliferative phenotype in mice. Hydroxymethylcytosine is in abundance in hematopoietic stem cells and displays specific distribution patterns, yet the function of this covalent modification is not fully understood. Recent data link TET2 with the function of cytosine deaminases as a pathway towards DNA demethylation, which has implications as well for B cell lymphomas and CML lymphoid blast crisis, which are linked with the actions of activation induced cytosine deaminase. Altogether, the available data implicate mutations in IDH1/2 and TET2 in promoting malignant transformation in several tissues, by disrupting epigenomics programming and altering gene expression patterning. Disclosures: Thompson: Agios Pharmaceuticals: Consultancy.

DNA methylation and hydroxymethylation associated with gene expression regulatory network during 3-methylcholanthrene induced lung cell malignant transformation

The Science of The Total Environment ◽

10.1016/j.scitotenv.2020.144839 ◽

2021 ◽

Vol 771 ◽

pp. 144839

Author(s):

Hong-qiang Chen ◽

Dong-jiao Chen ◽

Yan Li ◽

Fei Han ◽

Xiao Jiang ◽

...

Keyword(s):

Gene Expression ◽

Dna Methylation ◽

Malignant Transformation ◽

Regulatory Network

Abortive Infection and Malignant Transformation by Adenoviruses: Integration of Viral Dna and Control of Viral Gene Expression by Specific Patterns of DNA Methylation

Advances in Virus Research ◽

10.1016/s0065-3527(08)60793-9 ◽

1991 ◽

pp. 89-128 ◽

Cited By ~ 34

Author(s):

Walter Doerfler

Keyword(s):

Gene Expression ◽

Dna Methylation ◽

Malignant Transformation ◽

Viral Gene Expression ◽

Viral Gene ◽

Abortive Infection ◽

Viral Dna ◽

And Control

DEFECTIVE DNA METHYLATION IS ASSOCIATED WITH SSB GENE EXPRESSION, ANTI-SSB/LA DETECTION, AND LYMPHOCYTE INFILTRATION IN SALIVARY GLAND EPITHELIAL ACINI FROM PATIENTS WITH SJOGREN’S SYNDROME

10.26226/morressier.56e174d1d462b8028d88a622 ◽

2016 ◽

Author(s):

Yves Renaudineau

Keyword(s):

Gene Expression ◽

Dna Methylation ◽

Salivary Gland ◽

Sjögren’S Syndrome ◽

Sjögren's Syndrome ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Lymphocyte Infiltration ◽

Sjögren‘S Syndrome

Faculty Opinions recommendation of Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1116308.572315 ◽

2008 ◽

Author(s):

Kyong Soo Park ◽

Soo Heon Kwak

Keyword(s):

Gene Expression ◽

Skeletal Muscle ◽

Dna Methylation ◽

Human Skeletal Muscle

Faculty Opinions recommendation of Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3095956.2777057 ◽

2010 ◽

Author(s):

Michael Symonds ◽

Sylvain Sebert

Keyword(s):

Gene Expression ◽

Dna Methylation ◽

Pancreatic Islets ◽

Intrauterine Growth Restriction ◽

Growth Restriction ◽

Intrauterine Growth

DNA Methylation Inhibites ANXA1 Gene Expression in Nasopharyngeal Carcinoma Cell Lines*

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS ◽

10.3724/sp.j.1206.2009.00170 ◽

2009 ◽

Vol 36 (10) ◽

pp. 1319-1326 ◽

Cited By ~ 3

Author(s):

Shuang-Xiang TAN ◽

Rui-Cheng HU ◽

Ai-Guo DAI ◽

Cen-E TANG ◽

Hong YI ◽

...

Keyword(s):

Gene Expression ◽

Dna Methylation ◽

Nasopharyngeal Carcinoma ◽

Cell Lines ◽

Carcinoma Cell ◽

Nasopharyngeal Carcinoma Cell ◽

Carcinoma Cell Lines

Novel Insights into Rheumatoid Arthritis Through Characterisation of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients with Differing Numbers of Swollen Joints

SSRN Electronic Journal ◽

10.2139/ssrn.3576744 ◽

2020 ◽

Author(s):

Enrico Ferrero ◽

Andrew Li Yim ◽

Klio Maratou ◽

Huw D. Lewis ◽

George Royal ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Gene Expression ◽

Dna Methylation

Chemoprotective Effects of Propolis on Aflatoxin B1-Induced Hepatotoxicity in Rats: Oxidative Damage and Hepatotoxicity by Modulating TP53, Oxidative Stress

Current Proteomics ◽

10.2174/1570164617666190925121720 ◽

2020 ◽

Vol 17 (3) ◽

pp. 191-199

Author(s):

Seval Yilmaz ◽

Fatih Mehmet Kandemir ◽

Emre Kaya ◽

Mustafa Ozkaraca

Keyword(s):

Oxidative Stress ◽

Gene Expression ◽

Oxidative Damage ◽

Aflatoxin B1 ◽

Tp53 Gene ◽

Control Group ◽

Glutathione S Transferase ◽

Gene Expressions ◽

Cat Gene ◽

Gst Activity

Objective: This study aimed to detect hepatic oxidative damage caused by aflatoxin B1 (AFB1), as well as to examine how propolis protects against hepatotoxic effects of AFB1. Method: Rats were split into four groups as control group, AFB1 group, propolis group, AFB1+ propolis group. Results: There was significant increase in malondialdehyde (MDA) level and tumor suppressor protein (TP53) gene expression, Glutathione (GSH) level, Catalase (CAT) activity, CAT gene expression decreased in AFB1 group in blood. MDA level and Glutathione-S-Transferase (GST) activity, GST and TP53 gene expressions increased in AFB1 group, whereas GSH level and CAT activity alongside CAT gene expression decreased in liver. AFB1+propolis group showed significant decrease in MDA level, GST activity, TP53 and GST gene expressions, GSH level and CAT activity and CAT gene expression increased in liver compared to AFB1 group. Conclusion: These results suggest that propolis may potentially be natural agent that prevents AFB1- induced oxidative stress and hepatotoxicity.