scholarly journals Inflammatory response and bone healing capacity of two porous calcium phosphate ceramics in critical size cortical bone defects

2013 ◽  
Vol 102 (5) ◽  
pp. 1399-1407 ◽  
Author(s):  
Anindita Chatterjea ◽  
Johan van der Stok ◽  
Charlène B. Danoux ◽  
Huipin Yuan ◽  
Pamela Habibovic ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Inflammatory Response ◽  
Cortical Bone ◽  
Bone Healing ◽  
Critical Size ◽  
Bone Defects ◽  
Calcium Phosphate Ceramics

scholarly journals Preliminary in Vivo Evaluation of Bone Healing in Critical Size Bone Defects Implanted with an Injectable Calcium Phosphate Bone Cement (Osteopaste)

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Che Nor Zarida Che Seman ◽  
Zamzuri Zakaria ◽  
Zunariah Buyong ◽  
Mohd Shukrimi Awang ◽  
Ahmad Razali Md Ralib @ Md Raghib
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Bone Tissue ◽  
Bone Repair ◽  
Critical Size ◽  
Healing Process ◽  
Bone Defects ◽  
Calcium Phosphate Bone Cement ◽  
Rabbit Tibia

Introduction: A novel injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tricalcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could be a new promising biomaterial for bone repair and has a potential in bone tissue engineering.

scholarly journals Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 428 ◽  
Author(s):  
Rebecca Rothe ◽  
Sandra Hauser ◽  
Christin Neuber ◽  
Markus Laube ◽  
Sabine Schulze ◽  
...  
Keyword(s):  
Bone Healing ◽  
Targeted Delivery ◽  
Metabolic Diseases ◽  
Critical Size ◽  
Critical Evaluation ◽  
Bone Defects ◽  
Delivery Systems ◽  
Stimulus Responsive ◽  
Implant Coatings ◽  
Carrier Systems

Bone defects of critical size after compound fractures, infections, or tumor resections are a challenge in treatment. Particularly, this applies to bone defects in patients with impaired bone healing due to frequently occurring metabolic diseases (above all diabetes mellitus and osteoporosis), chronic inflammation, and cancer. Adjuvant therapeutic agents such as recombinant growth factors, lipid mediators, antibiotics, antiphlogistics, and proangiogenics as well as other promising anti-resorptive and anabolic molecules contribute to improving bone healing in these disorders, especially when they are released in a targeted and controlled manner during crucial bone healing phases. In this regard, the development of smart biocompatible and biostable polymers such as implant coatings, scaffolds, or particle-based materials for drug release is crucial. Innovative chemical, physico- and biochemical approaches for controlled tailor-made degradation or the stimulus-responsive release of substances from these materials, and more, are advantageous. In this review, we discuss current developments, progress, but also pitfalls and setbacks of such approaches in supporting or controlling bone healing. The focus is on the critical evaluation of recent preclinical studies investigating different carrier systems, dual- or co-delivery systems as well as triggered- or targeted delivery systems for release of a panoply of drugs.

scholarly journals Histological Comparison between Biphasic Calcium Phosphate and Deproteinized Bovine Bone on Critical-Size Bone Defects

2021 ◽  
Vol 32 (1) ◽  
pp. 26-33
Author(s):  
Marina Araujo Brito ◽  
Leomar Emanuel Almeida Mecca ◽  
Thais dos Santos Sedoski ◽  
Tayline Mroczek ◽  
Marcela Claudino ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Tissue ◽  
Biphasic Calcium Phosphate ◽  
Bone Repair ◽  
Critical Size ◽  
Blood Clot ◽  
Bone Defects ◽  
Bovine Bone ◽  
Tissue Area ◽  
Deproteinized Bovine Bone

Abstract The limited options for bone repair have led to an extensive research of the field and the development of alloplastic and xenogeneic grafts. The purpose of this study was to evaluate bone repair with two bone substitutes: deproteinized bovine bone (DBB) and biphasic calcium phosphate ceramic (BCP) in critical-size defect. A total of 8-mm defects were made in the parietal bones of rabbits (n=12). The animals were divided into three experimental groups: sham (defect filled with a blood clot), DBB (defect filled with DBB), and BCP (defect filled with BCP). After the experimental periods of 15 and 45 days, the animals were euthanized and submitted to histomorphometric analysis. The total defect area, mineralized tissue area, biomaterial area, and soft tissue area were evaluated. A greater amount of immature bone tissue and biomaterial particles were observed in the BCP group compared to DBB and sham at 45 days (p<0.05). There was no difference in the qualitative pattern of bone deposition between DBB and BCP. However, the sham group did not show osteoid islands along with the defect, presenting a greater amount of collagen fibers as well in relation to the DBB and BCP groups. There was a greater number of inflammatory cells in the DBB at 45 days compared to BCP and sham groups. In conclusion, BCP and DBB are options for optimizing the use of bone grafts for maxillofacial rehabilitation. Bone defects treated with BCP showed greater deposition of bone tissue at 45 days.

scholarly journals Selective laser melting-produced porous titanium scaffolds regenerate bone in critical size cortical bone defects

2012 ◽  
Vol 31 (5) ◽  
pp. 792-799 ◽  
Author(s):  
Johan Van der Stok ◽  
Olav P. Van der Jagt ◽  
Saber Amin Yavari ◽  
Mirthe F. P. De Haas ◽  
Jan H. Waarsing ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Selective Laser Melting ◽  
Critical Size ◽  
Bone Defects ◽  
Porous Titanium ◽  
Laser Melting

Effects of autologous platelet rich plasma gel and calcium phosphate biomaterials on bone healing in an ulnar ostectomy model in dogs

2009 ◽  
Vol 22 (06) ◽  
pp. 460-466 ◽  
Author(s):  
J.-G. Grand ◽  
E. Dalibert ◽  
B. Fellah ◽  
O. Gauthier ◽  
G.W. Niebauer ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Healing ◽  
Critical Size ◽  
Platelet Rich Plasma ◽  
Long Bone ◽  
Histological Evaluation ◽  
Radiographic Evaluation ◽  
New Bone Formation ◽  
Prp Gel

SummaryThe aim of the study was to evaluate the bone healing properties of an osteopromotive platelet rich plasma (PRP) gel in combination with osteoconductive calcium phosphate (CaP) ceramic granules in a long-bone critical size defect in dogs. A standardised 2 cm long ulnar ostectomy was performed bilaterally in four dogs to compare new-bone formation by CaP matrix with and without association with PRP. Radiographic and histological evaluations were performed blindly. Radiographic evaluation was performed at three, six, nine, 12 and 16 weeks postoperatively. Quantitative measurements of new-bone formation were compared using statistical analysis. At explantation 16 weeks after surgery, no significant ossification was present, neither with CaP granules alone nor in association with PRP gel, and there was no difference of radiodensity between the groups. Qualitative histological evaluation demonstrated for both types of implants the presence of non-mineralised fibrous connective tissue around the CaP granules. New-bone formation was only present to a very small extent within the macropores of the CaP granules at the distal boneimplant interface. In our model which exhibited very limited osteoconduction, neither the CaP granules alone nor in association with PRP were sufficient to stimulate bone healing. In this canine model employing a critical size ulnar gap, the combination of CaP granules and PRP did not effectively promote bone regeneration.

Association of hyaluronic acid with a collagen scaffold may improve bone healing in critical-size bone defects

2011 ◽  
Vol 23 (8) ◽  
pp. 938-942 ◽  
Author(s):  
Beatriz de Brito Bezerra ◽  
Mariana Amade Mendes Brazão ◽  
Mirella Lindoso Gomes de Campos ◽  
Márcio Zaffalon Casati ◽  
Enilson Antônio Sallum ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Bone Healing ◽  
Critical Size ◽  
Collagen Scaffold ◽  
Bone Defects
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