scholarly journals Inactivation ofVhlin Osteochondral Progenitor Cells Causes High Bone Mass Phenotype and Protects Against Age-Related Bone Loss in Adult Mice

2014 ◽  
Vol 29 (4) ◽  
pp. 820-829 ◽  
Author(s):  
Tujun Weng ◽  
Yangli Xie ◽  
Junlan Huang ◽  
Fengtao Luo ◽  
Lingxian Yi ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Mass ◽  
Progenitor Cells ◽  
High Bone Mass ◽  
Adult Mice ◽  
Age Related ◽  
High Bone ◽  
High Bone Mass Phenotype

Intrauterine stress induces bone loss in adult offspring of C3H/HeJ mice having high bone mass phenotype but not C57BL/6J mice with low bone mass phenotype

Bone ◽  
2016 ◽  
Vol 87 ◽  
pp. 114-119 ◽  
Author(s):  
M. Raygorodskaya ◽  
Y. Gabet ◽  
C. Shochat ◽  
E. Kobyliansky ◽  
A. Torchinsky ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Mass ◽  
Adult Offspring ◽  
Low Bone Mass ◽  
High Bone Mass ◽  
High Bone ◽  
High Bone Mass Phenotype

scholarly journals Mice lacking DKK1 in T cells exhibit high bone mass and are protected from estrogen deficiency-induced bone loss

iScience ◽  
2021 ◽  
pp. 102224
Author(s):  
Juliane Lehmann ◽  
Sylvia Thiele ◽  
Ulrike Baschant ◽  
Tilman D. Rachner ◽  
Christof Niehrs ◽  
...  
Keyword(s):  
T Cells ◽  
Bone Loss ◽  
Bone Mass ◽  
Estrogen Deficiency ◽  
High Bone Mass ◽  
High Bone

scholarly journals Sex dimorphic regulation of osteoprogenitor progesterone in bone stromal cells

2017 ◽  
Vol 59 (4) ◽  
pp. 351-363 ◽  
Author(s):  
Alexander Kot ◽  
Zhendong A Zhong ◽  
Hongliang Zhang ◽  
Yu-An Evan Lay ◽  
Nancy E Lane ◽  
...  
Keyword(s):  
Mouse Model ◽  
Bone Mass ◽  
Gene Transcription ◽  
Conditional Knockout ◽  
Sequencing Analysis ◽  
Wild Type ◽  
High Bone Mass ◽  
Matrix Interaction ◽  
High Bone ◽  
High Bone Mass Phenotype

Increasing peak bone mass is a promising strategy to prevent osteoporosis. A mouse model of global progesterone receptor (PR) ablation showed increased bone mass through a sex-dependent mechanism. Cre-Lox recombination was used to generate a mouse model of osteoprogenitor-specific PR inactivation, which recapitulated the high bone mass phenotype seen in the PR global knockout mouse mode. In this work, we employed RNA sequencing analysis to evaluate sex-independent and sex-dependent differences in gene transcription of osteoprogenitors of wild-type and PR conditional knockout mice. PR deletion caused marked sex hormone-dependent changes in gene transcription in male mice as compared to wild-type controls. These transcriptional differences revealed dysregulation in pathways involving immunomodulation, osteoclasts, bone anabolism, extracellular matrix interaction and matrix interaction. These results identified many potential mechanisms that may explain our observed high bone mass phenotype with sex differences when PR was selectively deleted in the MSCs.

scholarly journals Novel LRP5 Missense Mutation in a Patient With a High Bone Mass Phenotype Results in Decreased DKK1-Mediated Inhibition of Wnt Signaling*

2007 ◽  
Vol 22 (5) ◽  
pp. 708-716 ◽  
Author(s):  
Wendy Balemans ◽  
Jean-Pierre Devogelaer ◽  
Erna Cleiren ◽  
Elke Piters ◽  
Emanuelle Caussin ◽  
...  
Keyword(s):  
Bone Mass ◽  
Wnt Signaling ◽  
Missense Mutation ◽  
High Bone Mass ◽  
High Bone ◽  
High Bone Mass Phenotype

NFATC2-knock-out mice reveal a high bone mass phenotype

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S40
Author(s):  
M. Rauner⁎ ◽  
W. Bauer ◽  
I. Habermann ◽  
M. Haase ◽  
C. Goettsch ◽  
...  
Keyword(s):  
Bone Mass ◽  
High Bone Mass ◽  
Knock Out ◽  
High Bone ◽  
High Bone Mass Phenotype ◽  
Knock Out Mice

scholarly journals F-Spondin Deficient Mice Have a High Bone Mass Phenotype

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e98388 ◽  
Author(s):  
Glyn D. Palmer ◽  
Mukundan G. Attur ◽  
Qing Yang ◽  
James Liu ◽  
Paxton Moon ◽  
...  
Keyword(s):  
Bone Mass ◽  
High Bone Mass ◽  
High Bone ◽  
High Bone Mass Phenotype ◽  
Deficient Mice
Sign in / Sign up

Export Citation Format

Share Document