Relationship of the plasminogen activator/plasmin cascade to osteoclast invasion and mineral resorption in explanted fetal metatarsal bones

2009 ◽  
Vol 9 (6) ◽  
pp. 891-902 ◽  
Author(s):  
Gaetane Leloup ◽  
Jean-Marie Delaisse ◽  
Gilbert Vaes
1972 ◽  
Vol 238 (79) ◽  
pp. 15-17 ◽  
Author(s):  
C. N. CHESTERMAN ◽  
M. J. ALLINGTON ◽  
A. A. SHARP

1986 ◽  
Vol 55 (01) ◽  
pp. 008-011 ◽  
Author(s):  
David J Loskutoff ◽  
Karen Roegner ◽  
Larry A Erickson ◽  
Raymond R Schleef ◽  
Anna Huttenlocher ◽  
...  

SummaryGlucocorticoids decrease plasminogen activator (PA) activity in HTC rat hepatoma cells by inducing a specific inhibitor of PA activity (PAI). This inhibitor is similar in several biochemical properties to the PAI purified from bovine aortic endothelial cells (BAEs). We have used reverse fibrin autography and antiserum against BAE PAI to establish more fully the biochemical and immunological relationship of these inhibitors. Both inhibitors migrated with an apparent Mr of approximately 50,000, and the activity of both PAIs was stimulated by treatment with SDS suggesting that each of these molecules exists in both an active and a latent form. Antiserum to the BAE PAI immunoprecipi-tated all of the HTC PAI demonstrable by reverse fibrin autography. Finally, using this antiserum in a functional immunoassay, we have demonstrated that dexamethasone increases both active and latent PAI made by HTC cells. These results, indicate that HTC PAI and BAE PAI are antigenically as well as biochemically related molecules.


CHEST Journal ◽  
1998 ◽  
Vol 113 (5) ◽  
pp. 1257-1263 ◽  
Author(s):  
Raja T. Abboud ◽  
Anwuli Felix Ofulue ◽  
Raul H. Samares ◽  
Nestor L. Muller

Circulation ◽  
2004 ◽  
Vol 109 (5) ◽  
pp. 607-612 ◽  
Author(s):  
Stefano Volpato ◽  
Marco Pahor ◽  
Luigi Ferrucci ◽  
Eleanor M. Simonsick ◽  
Jack M. Guralnik ◽  
...  

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