Therapeutic plasma exchange in anti-N-methyl-D-aspartate-receptor (anti-NMDA-R) encephalitis associated with benign ovarian teratoma

2012 ◽  
Vol 27 (4) ◽  
pp. 227-228 ◽  
Author(s):  
Rashmi Batra ◽  
Yinghua Pang ◽  
Mark T. Friedman
Keyword(s):  
Plasma Exchange ◽  
Therapeutic Plasma Exchange ◽  
Ovarian Teratoma ◽  
Aspartate Receptor

Intravenous methylprednisolone versus therapeutic plasma exchange for treatment of anti-n-methyl-d-aspartate receptor antibody encephalitis: A retrospective review

2015 ◽  
Vol 30 (4) ◽  
pp. 212-216 ◽  
Author(s):  
Allen D. DeSena ◽  
Daniel K. Noland ◽  
Karen Matevosyan ◽  
Kathryn King ◽  
Lauren Phillips ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Retrospective Review ◽  
Therapeutic Plasma Exchange ◽  
Intravenous Methylprednisolone ◽  
Receptor Antibody ◽  
Aspartate Receptor

Adjunct therapeutic plasma exchange for anti-N-methyl-D-aspartate receptor antibody encephalitis: A case report and review of literature

2011 ◽  
Vol 26 (6) ◽  
pp. 362-365 ◽  
Author(s):  
M. Kamran Mirza ◽  
Jennifer Pogoriler ◽  
Kristen Paral ◽  
Vijayalakshmi Ananthanarayanan ◽  
Saptarshi Mandal ◽  
...  
Keyword(s):  
Case Report ◽  
Plasma Exchange ◽  
Therapeutic Plasma Exchange ◽  
Review Of Literature ◽  
Receptor Antibody ◽  
Aspartate Receptor

Therapeutic Plasma Exchange Application in Children Requires Individual Decision

2020 ◽  
Author(s):  
Gürkan Atay ◽  
Demet Demirkol
Keyword(s):  
Plasma Exchange ◽  
Vascular Access ◽  
Pediatric Patients ◽  
Demyelinating Disease ◽  
Pediatric Intensive Care ◽  
Therapeutic Plasma Exchange ◽  
Transplantation Rejection ◽  
Access Problems ◽  
Uremic Syndrome

AbstractTherapeutic plasma exchange (TPE) is a treatment administered with the aim of removing a pathogenic material or compound causing morbidity in a variety of neurologic, hematologic, renal, and autoimmune diseases. In this study, we aimed to assess the indications, efficacy, reliability, complications, and treatment response of pediatric patients for TPE. This retrospective study analyzed data from 39 patients aged from 0 to 18 years who underwent a total of 172 TPE sessions from January 2015 to April 2018 in a tertiary pediatric intensive care unit. Indications for TPE were, in order of frequency, macrophage activation syndrome (28.2%, n = 11), renal transplantation rejection (15.4%, n = 6), liver failure (15.4%, n = 6), Guillain–Barre's syndrome (15%, n = 6), hemolytic uremic syndrome (7.7%, n = 3), acute demyelinating disease (7.7%, n = 3), septic shock (5.1%, n = 2), and intoxication (5.1%, n = 2). No patient had any adverse event related to the TPE during the procedure. The TPE session was ended prematurely in one patient due to insufficient vascular access and lack of blood flow (2.6%). In the long term, thrombosis due to the indwelling central catheter occurred (5.1%, n = 2). TPE appears to be an effective first-stage or supplementary treatment in a variety of diseases, may be safely used in pediatric patients, and there are significant findings that its area of use will increase. In experienced hands and when assessed carefully, it appears that the rate of adverse reactions and vascular access problems may be low enough to be negligible.

Therapeutic plasma exchange in intensive care and intensive nephrology

2018 ◽  
Vol 20 (4) ◽  
pp. 394-403
Author(s):  
M. S. Vetsheva ◽  
◽  
K.E Loss . ◽  
O.L. Podkorytova ◽  
E.V. Lebedkov ◽  
...  
Keyword(s):  
Intensive Care ◽  
Plasma Exchange ◽  
Therapeutic Plasma Exchange

Therapeutic plasma exchange in a single center: Ibni Sina experience

2004 ◽  
Vol 30 (3) ◽  
pp. 181-184 ◽  
Author(s):  
Önder Arslan ◽  
Mutlu Arat ◽  
Ibrahim Tek ◽  
Erol Ayyildiz ◽  
Osman Ilhan
Keyword(s):  
Plasma Exchange ◽  
Therapeutic Plasma Exchange ◽  
Single Center

scholarly journals Pediatric Therapeutic Plasma Exchange: Coming of Age?

2021 ◽  
Author(s):  
Saptarshi Mandal ◽  
Aditi Sinha
Keyword(s):  
Plasma Exchange ◽  
Coming Of Age ◽  
Therapeutic Plasma Exchange

scholarly journals Anti-N-Methyl-D-Aspartate Receptor Encephalitis with Decrease in Blood Flow in Cerebellum

2021 ◽  
pp. 17-23
Author(s):  
Koji Obara ◽  
Tomoko Ono ◽  
Itaru Toyoshima
Keyword(s):  
Working Memory ◽  
Blood Flow ◽  
Ovarian Teratoma ◽  
Emission Computed Tomography ◽  
High Dose ◽  
Promising Alternative ◽  
Flow Monitoring ◽  
Aspartate Receptor ◽  
Nmdar Encephalitis ◽  
Consciousness Disturbance

In anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, progressive cerebellar atrophy potentially leads to severe sequelae. We encountered a patient with anti-NMDAR antibody encephalitis who showed a decrease of blood flow in the cerebellum. A 15-year-old girl presented with consciousness disturbance. Influenza encephalopathy was suspected, and she was treated with glucocorticoid pulse therapy, high-dose intravenous immunoglobulins, and plasma exchange sequentially. She subsequently underwent left oophorectomy due to the presence of anti-NMDAR antibodies and a left ovarian teratoma. In spite of the surgery, her neuropsychiatric symptoms persisted, and she recovered slowly after the introduction of oral methotrexate (MTX). Sequential cerebral blood flow monitoring with single-photon emission computed tomography showed marked cerebellar hypoperfusion. Although mild impairments including working memory and verbal fluency persisted, she eventually returned to high school 3 years after onset. Profound cerebellar hypoperfusion including lobules VI and VII may be the reason for her working memory impairment and speaking problems. Oral MTX may be a promising alternative treatment for some refractory cases of anti-NMDAR encephalitis.

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