Functional receptor for platelet-derived growth factor in rat embryonic heart-derived myocytes: Role of sequestered Ca2+ stores in receptor signaling and antagonism by arginine vasopressin

2002 ◽  
Vol 84 (4) ◽  
pp. 736-749 ◽  
Author(s):  
Margaret A. Brostrom ◽  
Sally Meiners ◽  
Charles O. Brostrom
2006 ◽  
Vol 140 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Tetsuya Adachi ◽  
Satoko Hanaka ◽  
Tomoko Yano ◽  
Koichi Yamamura ◽  
Hisanao Yoshihara ◽  
...  

1995 ◽  
Vol 270 (46) ◽  
pp. 27595-27600 ◽  
Author(s):  
Daruka Mahadevan ◽  
Jin-Chen Yu ◽  
Jose W. Saldanha ◽  
Narmada Thanki ◽  
Peter McPhie ◽  
...  

1987 ◽  
Vol 80 (9) ◽  
pp. 591-593
Author(s):  
A J Barrett

At this meeting of the RSM's Section of Pathology, the regulation of haemopoietic stem cells and growth factors regulating various cell lines were described, and the role of oncogenes, platelet-derived growth factor and nerve growth factor in growth regulation was discussed.


1985 ◽  
Vol 9 (3) ◽  
pp. 399-405 ◽  
Author(s):  
Rita Michalevicz ◽  
Gillian E. Francis ◽  
Gillian M. Price ◽  
A.Victor Hoffbrand

Science ◽  
1986 ◽  
Vol 232 (4746) ◽  
pp. 87-90 ◽  
Author(s):  
BC Berk ◽  
RW Alexander ◽  
TA Brock ◽  
MA Gimbrone ◽  
RC Webb

Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells that has been implicated in the pathogenesis of atherosclerosis. The potential role of PDGF in the altered vasoreactivity of atherosclerotic vessels has been studied through an examination of its effects on contractility in the rat aorta. PDGF caused a concentration-dependent contraction of aortic strips and was significantly more potent on a molar basis than the classic vasoconstrictor peptide angiotensin II. Furthermore, PDGF increased the cytosolic free calcium concentration in cultured rat aortic smooth muscle cells. These observations suggest a new biological activity for PDGF that may contribute to the enhanced vasoreactivity of certain atherosclerotic vessels.


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