Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ER? or ER?

2003 ◽  
Vol 90 (2) ◽  
pp. 315-326 ◽  
Author(s):  
David G. Monroe ◽  
Barbara J. Getz ◽  
Steven A. Johnsen ◽  
B. Lawrence Riggs ◽  
Sundeep Khosla ◽  
...  
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Cell Lines ◽  
Osteoblastic Cell ◽  
Endogenous Gene ◽  
Human Osteoblastic Cell ◽  
Specific Regulation

scholarly journals Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies

2016 ◽  
Vol 35 (2) ◽  
pp. 150-160 ◽  
Author(s):  
Flor M. Pérez-Campo ◽  
Tobias May ◽  
Jeannette Zauers ◽  
Carolina Sañudo ◽  
Jesús Delgado-Calle ◽  
...  
Keyword(s):  
Cell Lines ◽  
Osteoblastic Cell ◽  
Human Osteoblastic Cell

scholarly journals Effects of orbital spaceflight on human osteoblastic cell physiology and gene expression

Bone ◽  
2000 ◽  
Vol 26 (4) ◽  
pp. 325-331 ◽  
Author(s):  
S.A. Harris ◽  
M. Zhang ◽  
L.S. Kidder ◽  
G.L. Evans ◽  
T.C. Spelsberg ◽  
...  
Keyword(s):  
Gene Expression ◽  
Osteoblastic Cell ◽  
Cell Physiology ◽  
Human Osteoblastic Cell

scholarly journals Genes Regulated in Metastatic Osteosarcoma: Evaluation by Microarray Analysis in Four Human and Two Mouse Cell Line Systems

Sarcoma ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Roman Muff ◽  
Ram Mohan Ram Kumar ◽  
Sander M. Botter ◽  
Walter Born ◽  
Bruno Fuchs
Keyword(s):  
Gene Expression ◽  
Cell Line ◽  
Cell Lines ◽  
Expression Profiles ◽  
Treatment Strategies ◽  
Metastatic Potential ◽  
New Drugs ◽  
Differentially Expressed ◽  
Osteoblastic Cell ◽  
Osteoblastic Cell Line

Osteosarcoma (OS) is a rare bone neoplasm that affects mainly adolescents. It is associated with poor prognosis in case of metastases formation. The search for metastasis predicting markers is therefore imperative to optimize treatment strategies for patients at risk and important for the search of new drugs for the treatment of this devastating disease. Here, we have analyzed by microarray the differential gene expression in four human and two mouse OS cell line systems consisting of parental cell lines with low metastatic potential and derivatives thereof with increased metastatic potential. Using two osteoblastic cell line systems, the most common OS phenotype, we have identified forty-eight common genes that are differentially expressed in metastatic cell lines compared to parental cells. The identified subset of metastasis relevant genes in osteoblastic OS overlapped only minimally with differentially expressed genes in the other four preosteoblast or nonosteoblastic cell line systems. The results imply an OS phenotype specific expression pattern of metastasis regulating proteins and form a basis for further investigation of gene expression profiles in patients’ samples combined with survival analysis with the aim to optimize treatment strategies to develop new drugs and to consequently improve the survival of patients with the most common form of osteoblastic OS.

193 Generation of Novel Reporter Cell Lines Facilitating the Measurement of Endogenous Gene Expression

2012 ◽  
Vol 48 ◽  
pp. 58
Author(s):  
S. Grooby ◽  
H.M. Astley ◽  
J. Elliott ◽  
T. Henley ◽  
K.M. Pytel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Reporter Cell ◽  
Endogenous Gene
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