Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors

2009 ◽  
Vol 11 (2) ◽  
pp. 193-199 ◽  
Author(s):  
Moustapha Kassem ◽  
Steven A. Harris ◽  
Thomas C. Spelsberg ◽  
B. Lawrence Riggs
Keyword(s):  
Gene Expression ◽  
Estrogen Receptors ◽  
Cell Line ◽  
Interleukin 6 ◽  
Osteoblastic Cell ◽  
Osteoblastic Cell Line ◽  
Human Osteoblastic Cell

scholarly journals Immunomodulatory Potential of Differently-Terminated Ultra-Small Silicon Carbide Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 573
Author(s):  
Tereza Bělinová ◽  
Iva Machová ◽  
David Beke ◽  
Anna Fučíková ◽  
Adam Gali ◽  
...  
Keyword(s):  
Silicon Carbide ◽  
Cell Line ◽  
Metabolic Activity ◽  
Immune Cell ◽  
Cellular Membrane ◽  
Osteoblastic Cell ◽  
Osteoblastic Cell Line ◽  
Human Osteoblastic Cell ◽  
Different Response ◽  
Small Nanoparticles

Ultra-small nanoparticles with sizes comparable to those of pores in the cellular membrane possess significant potential for application in the field of biomedicine. Silicon carbide ultra-small nanoparticles with varying surface termination were tested for the biological system represented by different human cells (using a human osteoblastic cell line as the reference system and a monocyte/macrophage cell line as immune cells). The three tested nanoparticle surface terminations resulted in the observation of different effects on cell metabolic activity. These effects were mostly noticeable in cases of monocytic cells, where each type of particle caused a completely different response (‘as-prepared’ particles, i.e., were highly cytotoxic, –OH terminated particles slightly increased the metabolic activity, while –NH2 terminated particles caused an almost doubled metabolic activity) after 24 h of incubation. Subsequently, the release of cytokines from such treated monocytes and their differentiation into activated cells was determined. The results revealed the potential modulation of immune cell behavior following stimulation with particular ultra-small nanoparticles, thus opening up new fields for novel silicon carbide nanoparticle biomedical applications.

scholarly journals Phase-independent Inhibition by Retinoic Acid of Mineralization Correlated with Loss of Tetranectin Expression in a Human Osteoblastic Cell Line.

2001 ◽  
Vol 26 (4) ◽  
pp. 227-233 ◽  
Author(s):  
Kousuke Iba ◽  
Hideki Chiba ◽  
Toshihiko Yamashita ◽  
Seiichi Ishii ◽  
Norimasa Sawada
Keyword(s):  
Retinoic Acid ◽  
Cell Line ◽  
Osteoblastic Cell ◽  
Osteoblastic Cell Line ◽  
Human Osteoblastic Cell
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