Androgen receptor stimulates bone sialoprotein (BSP) gene transcription via cAMP response element and activator protein 1/glucocorticoid response elements

2007 ◽  
Vol 102 (1) ◽  
pp. 240-251 ◽  
Author(s):  
Hideki Takai ◽  
Youhei Nakayama ◽  
Dong-Soon Kim ◽  
Masato Arai ◽  
Shouta Araki ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Gene Transcription ◽  
Bone Sialoprotein ◽  
Activator Protein 1 ◽  
Camp Response Element ◽  
Response Element ◽  
Response Elements ◽  
Activator Protein ◽  
Glucocorticoid Response ◽  
Glucocorticoid Response Elements

scholarly journals Transcriptional activation of the haem oxygenase-1 gene by cGMP via a cAMP response element/activator protein-1 element in primary cultures of rat hepatocytes

1998 ◽  
Vol 334 (1) ◽  
pp. 141-146 ◽  
Author(s):  
Stephan IMMENSCHUH ◽  
Vera HINKE ◽  
Andreas OHLMANN ◽  
Susanne GIFHORN-KATZ ◽  
Norbert KATZ ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Primary Cultures ◽  
Rat Hepatocytes ◽  
Protein Kinase G ◽  
Activator Protein 1 ◽  
Camp Response Element ◽  
Response Element ◽  
Activator Protein ◽  
Mrna Induction ◽  
Haem Oxygenase

The expression of the rate-limiting enzyme of haem degradation, haem oxygenase-1 (HO-1), can be induced by various stimuli, including lipopolysaccharide, tumour necrosis factor α and NO. The NO signal can be transmitted by cGMP, therefore this study was aimed at testing the activation of the HO-1 gene by cGMP. In primary cultures of rat hepatocytes, both HO-1 mRNA and protein were induced by the NO donor sodium nitroprusside and 8-bromo-cGMP. The HO-1 mRNA induction by cGMP was prevented by the specific protein kinase G inhibitor KT5823. The cGMP-dependent HO-1 mRNA induction was dose-dependent and transcriptionally regulated, as determined by studies with actinomycin D and a nuclear run-on assay. Cycloheximide lowered the cGMP-dependent induction of HO-1 mRNA to about one half. Luciferase reporter constructs driven by about 800 bp of the 5´-flanking region of the rat HO-1 gene were transiently transfected into primary rat hepatocytes; 8-bromo-cGMP caused a 6-fold induction, which was obliterated by deletion and mutation of the cAMP response element/activator protein-1 (CRE/AP-1) (-665/-654) site. Thus HO-1 induction by cGMP appears to be stimulated by the protein kinase G pathway and may be mediated mainly via a CRE/AP-1 element in the rat HO-1 promoter.

scholarly journals Rapid Nongenomic E2 Effects on p42/p44 MAPK, Activator Protein-1, and cAMP Response Element Binding Protein in Rat White Adipocytes

Endocrinology ◽  
2002 ◽  
Vol 143 (3) ◽  
pp. 930-940 ◽  
Author(s):  
Esther Garcia Dos Santos ◽  
Marie Noëlle Dieudonne ◽  
René Pecquery ◽  
Vincent Le Moal ◽  
Yves Giudicelli ◽  
...  
Keyword(s):  
Binding Protein ◽  
Camp Response Element Binding ◽  
Activator Protein 1 ◽  
Camp Response Element ◽  
Response Element ◽  
Activator Protein ◽  
White Adipocytes ◽  
Element Binding Protein

Disorders of the adrenal cortex

2020 ◽  
pp. 2331-2360
Author(s):  
Mark Sherlock ◽  
Mark Gurnell
Keyword(s):  
Adrenal Cortex ◽  
Gene Transcription ◽  
Sex Steroids ◽  
Glucocorticoid Receptors ◽  
Steroid Hormone ◽  
Response Elements ◽  
Glucocorticoid Response ◽  
Clinical Consequences ◽  
Glucocorticoid Response Elements ◽  
Target Gene Transcription

Three classes of steroid hormone are produced by the adrenal cortex after uptake of precursor cholesterol from the plasma—mineralocorticoids, glucocorticoids, and sex steroids—with classical endocrine feedback loops controlling their secretion. Glucocorticoids have more diverse and extensive roles than mineralocorticoids, regulating sodium and water homeostasis, glucose and carbohydrate metabolism, inflammation, and stress. These effects are mediated by the interaction of cortisol with ubiquitous glucocorticoid receptors, and the induction or repression of target gene transcription (via glucocorticoid response elements, GREs). Adrenocortical diseases are relatively uncommon, but they have detrimental clinical consequences and can be treated effectively. Hormonal deficiency or excess is usually the result of abnormal secretion.

scholarly journals NF-κB and Activator Protein 1 Response Elements and the Role of Histone Modifications in IL-1β-Induced TGF-β1 Gene Transcription

2005 ◽  
Vol 176 (1) ◽  
pp. 603-615 ◽  
Author(s):  
Kang-Yun Lee ◽  
Kazuhiro Ito ◽  
Ryuji Hayashi ◽  
Elen P. I. Jazrawi ◽  
Peter J. Barnes ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Histone Modifications ◽  
Activator Protein 1 ◽  
Response Elements ◽  
Activator Protein ◽  
Tgf Β1

scholarly journals Red wine metabolites modulate NF-κB, activator protein-1 and cAMP response element-binding proteins in human endothelial cells

2009 ◽  
Vol 103 (6) ◽  
pp. 807-814 ◽  
Author(s):  
Raffaella Canali ◽  
Raffaella Comitato ◽  
Roberto Ambra ◽  
Fabio Virgili
Keyword(s):  
Endothelial Cells ◽  
Transcription Factors ◽  
Binding Proteins ◽  
Red Wine ◽  
Camp Response Element Binding ◽  
Activator Protein 1 ◽  
Camp Response Element ◽  
Response Element ◽  
Activator Protein ◽  
Tnf Α

We have studied the effect of human serum, collected after red wine consumption (RWS), on TNF-α-dependent activation of transcription factors (NF-κB, activator protein-1 (AP-1) and cAMP response element-binding proteins) and on the expression of selected genes involved in cell adhesion or fibrinolysis processes in human primary endothelial cells (human umbilical vein endothelial cells (HUVEC)). Our data indicate that RWS containing RW metabolites, isolated after 40 min from an acute consume of wine (5 ml/kg body weight), induces nuclear translocation of NF-κB and AP-1 in the absence of any further stimulus. On the other hand, TNF-α treatment in the presence of RWS is associated with a delay in transcription factor activation and to a negative modulation on the expression of specific genes. Moreover, RWS stimulates c-jun binding to the tissue-type plasminogen activator cAMP responsive element consensus site modulating the expression of the specific gene downstream. These results confirm that RW metabolites affect the activity of different transcription factors playing an important preconditioning role in the modulation of the inflammatory pathway in endothelial cells. This is the first report on the effects of a complex food matrix, on the molecular mechanisms associated with inflammatory response in HUVEC cultured in condition that reproduces the physiological environment occurring in vivo.

AP-1 regulation of the rat bone sialoprotein gene transcription is mediated through a TPA response element within a glucocorticoid response unit in the gene promoter

1996 ◽  
Vol 15 (2) ◽  
pp. 119-130 ◽  
Author(s):  
Masato Yamauchi ◽  
Yorimasa Ogata ◽  
Richard H. Kim ◽  
Jack J. Li ◽  
Leonard P. Freedman ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Gene Promoter ◽  
Bone Sialoprotein ◽  
Response Element ◽  
Response Unit ◽  
Glucocorticoid Response ◽  
Rat Bone
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