Cucurbitane Triterpenoids from the Fruit Pulp ofMomordica charantiaand Their Cytotoxic Activity

2013 ◽  
Vol 60 (5) ◽  
pp. 526-530 ◽  
Author(s):  
Yun-Wen Liao ◽  
Chiy-Rong Chen ◽  
Jiunn-Jye Chuu ◽  
Hui-Chi Huang ◽  
Jue-Liang Hsu ◽  
...  
2012 ◽  
Vol 7 (12) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Yun-Wen Liao ◽  
Chiy-Rong Chen ◽  
Yueh-Hsiung Kuo ◽  
Jue-Liang Hsu ◽  
Wen-Ling Shih ◽  
...  

Three new cucurbitane-type triterpenoids, 5β,19-epoxy-23(R)-methoxycucurbita-6,24-dien-3β-ol (1), 5β,19-epoxy-23(S)-methoxycucurbita-6,24-dien-3β-ol (2), and 3β-hydroxy-23(R)-methoxycucurbita-6,24-dien-5β,19-olide (3), were isolated from the fruit pulp of Momordica charantia. Their structures were established on the basis of extensive NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and EI-MS studies. Compound 1 exhibited cytotoxic activity against the SK-Hep 1 cell line.


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