Reference intervals of carbohydrate antigen 19-9 in the apparently healthy adult population

Introduction: We established reference intervals for serum lipids in an apparently healthy adult population of Ambalappuzha North Grama panchayath in Alappuzha district of Kerala. Methods: This cross-sectional study was done on 447 apparently healthy individuals of both sexes aged between 18-75 years who attended a health camp organized by the Department of Biochemistry, Government T.D. MedicalCollege in association with the Ambalappuzha North Grama Panchayath.Samples were analyzed in a Beckman Clinical chemistry analyzer. Mean, standard deviation, median,90% condence limits for th th th median and central 95 percentile were calculated. The 2.5 and 97.5 percentiles formed the lower and upper reference limits of population. Statistical analysis was done using SPSS ver.16 software. Results:Reference interval for Total cholesterol was 132.2-262 mg/dl, for HDL-cholesterol 28.2-62 mg/dl ,for LDL-cholesterol 66.2-175 mg/dl, for triglyceride 65-218.8 mg/dl, for VLDL 13-43.8 mg/dl and Total cholesterol/HDL-cholesterol ratio 2.67 – 6.4.Reference intervals for Total cholesterol,LDL-cholesterol and Triglyceride were higher than the desirable limits suggested by NCEP ATP III guidelines and the reference intervals established by many studies. There was a gradual increase in these parameters with age up to 60 years. The reference intervals for HDLcholesterol were lower in both males and females. Total cholesterol and LDL-cholesterol were higher in females compared to males. Conclusion:There exists difference in reference intervals for various populations and hence there is a need for more population studies so that reference ranges for lipid parameters can be established which will help in better health care.

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Ethnic variation in certain hematological and biochemical reference intervals in a south Indian healthy adult population

European Journal of Internal Medicine ◽

10.1016/j.ejim.2007.06.010 ◽

2008 ◽

Vol 19 (1) ◽

pp. 46-50 ◽

Cited By ~ 15

Author(s):

M. Sundaram ◽

J. Mohanakrishnan ◽

K.G. Murugavel ◽

E.M. Shankar ◽

S. Solomon ◽

...

Keyword(s):

Healthy Adult ◽

Adult Population ◽

Reference Intervals ◽

Ethnic Variation ◽

South Indian

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Chlamydia trachomatis genital infection in apparently healthy adult population of Tamil Nadu, India: a population-based study

International Journal of STD & AIDS ◽

10.1258/095646204322637272 ◽

2004 ◽

Vol 15 (1) ◽

pp. 51-55 ◽

Cited By ~ 19

Author(s):

A G Joyee ◽

S P Thyagarajan ◽

P Rajendran ◽

R Hari ◽

P Balakrishnan ◽

...

Keyword(s):

Chlamydia Trachomatis ◽

Tamil Nadu ◽

Healthy Adult ◽

Adult Population ◽

Population Based ◽

Genital Infection ◽

Population Based Study ◽

Apparently Healthy

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Plasma midregional proadrenomedullin (MR-proADM) concentrations and their biological determinants in a reference population

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2017-1044 ◽

2018 ◽

Vol 56 (7) ◽

pp. 1161-1168 ◽

Cited By ~ 7

Author(s):

Magdalena Krintus ◽

Marek Kozinski ◽

Federica Braga ◽

Jacek Kubica ◽

Grazyna Sypniewska ◽

...

Keyword(s):

Reference Group ◽

Adult Population ◽

Reference Population ◽

Cross Sectional Study ◽

Reference Intervals ◽

Cross Sectional ◽

Multiple Organs ◽

Laboratory Test Results ◽

Biological Determinants ◽

Apparently Healthy

Abstract Background: Midregional proadrenomedullin (MR-proADM) is emerging as a prognostic biomarker for detecting the failure of multiple organs. Establishment of scientifically robust reference intervals facilitates interpretation of laboratory test results. The objectives of this study were (i) to establish reliable reference intervals for plasma MR-proADM using a commercially available automated fluoroimmunoassay in apparently healthy individuals, and (ii) to identify biological determinants of MR-proADM concentrations. Methods: A total of 506 questionnaire-identified apparently healthy adults were enrolled in a single-center, cross-sectional study. A final reference group (n=172) was selected after exclusion of obese individuals, those with increased values of laboratory biomarkers indicating asymptomatic myocardial injury or dysfunction, ongoing inflammation, diabetes, dyslipidemia and renal dysfunction and outliers. Results: The 2.5th and 97.5th percentile intervals for MR-proADM values in the reference group (90% confidence interval) were 0.21 (0.19–0.23) and 0.57 (0.55–0.59) nmol/L, respectively. Although older age, higher values of HbA1c, C-reactive protein, B-type natriuretic peptide and body mass index, together with a history of smoking and a decreased estimated glomerular filtration rate were significantly associated with increasing concentrations of MR-proADM in both univariate and multivariate analyses, magnitudes of these relationships were modest and did not substantially influence MR-proADM reference intervals. Sex-dependent difference in MR-proADM reference intervals was not detected [0.19 (0.16–0.22)–0.56 (0.54–0.60) nmol/L in females vs. 0.22 (0.20–0.25)–0.58 (0.57–0.63) nmol/L in males]. Conclusions: Our study successfully established robust reference intervals for MR-proADM concentrations in plasma. Considering the negligible influence of potential biological determinants on plasma MR-proADM, we recommend the adoption of single reference intervals for adult population as a whole.

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