scholarly journals Long non‐coding RNA NEAT1 and its targets (microRNA‐21 and microRNA‐125a) in rheumatoid arthritis: Altered expression and potential to monitor disease activity and treatment outcome

2021 ◽  
Author(s):  
Junfeng Yang ◽  
Shanfu Wang ◽  
Lei Liu ◽  
Jianwei Wang ◽  
Yang Shao
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Outcome ◽  
Disease Activity ◽  
Altered Expression ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Silencing of Long Non-coding RNA HOTTIP Reduces Inflammation in Rheumatoid Arthritis by Demethylation of SFRP1

2020 ◽  
Vol 19 ◽  
pp. 468-481 ◽  
Author(s):  
Xumin Hu ◽  
Jianhua Tang ◽  
Xuyun Hu ◽  
Peng Bao ◽  
Weixi Deng ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA HEIH: a novel tumor activator in multiple cancers

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jie-yu Sun ◽  
Ming-ming Ni
Keyword(s):  
Tumor Stage ◽  
Advanced Tumor Stage ◽  
Altered Expression ◽  
Human Cancers ◽  
Advanced Tumor ◽  
Non Coding Rna ◽  
Different Types ◽  
Recent Developments ◽  
Underlying Mechanisms ◽  
Long Non Coding Rna

AbstractThe last decade has witnessed the altered expression levels of long non-coding RNA HEIH in different types of cancer. More than half of the HEIH studies in cancer have been published within the last two years. To our knowledge, this is the first review to discuss very recent developments and insights into HEIH contribution to carcinogenesis. The functional role, molecular mechanism, and clinical significance of HEIH in human cancers are described in detail. The expression of HEIH is elevated in a broad spectrum of cancers, and its disorder contributes to cell proliferation, migration, invasion, and drug resistance of cancer cells through different underlying mechanisms. In addition, the high expression of HEIH is significantly associated with advanced tumor stage, tumor size and decreased overall survival, suggesting HEIH may function as a prognostic biomarker and potential therapeutic target for human cancers.

Long Non-Coding RNA NEAT1 Knockdown Alleviates Rheumatoid Arthritis by Reducing IL-18 through p300/CBP Repression

Inflammation ◽  
2021 ◽  
Author(s):  
Tuanmao Guo ◽  
Yanli Xing ◽  
Zhongning Chen ◽  
Haiyun Zhu ◽  
Lan Yang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long Non-Coding RNA Expression Profiling in Aging Rats with Erectile Dysfunction

2015 ◽  
Vol 37 (4) ◽  
pp. 1513-1526 ◽  
Author(s):  
Lianjun Pan ◽  
Jiehua Ma ◽  
Feng Pan ◽  
Dan Zhao ◽  
Jianping Gao
Keyword(s):  
Erectile Dysfunction ◽  
Expression Profiles ◽  
Critical Role ◽  
Altered Expression ◽  
Aged People ◽  
Age Related ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Rna Expression Profiling ◽  
Long Non Coding Rna

Background/Aims: Erectile dysfunction (ED) in aged people remains a topic of interest to andrological physicians. Long non-coding RNAs (lncRNAs), which form the largest group of non-coding RNAs, have been shown to regulate various biological processes. The function of lncRNAs in age-related erectile dysfunction (A-ED) pathogenesis remains poorly understood. Methods: This study aims to assess the differential expression profiles of mRNAs and lncRNAs between A-ED and normal control (NC) samples. Using a second-generation lncRNA microarray, we detected a total of 8,744 lncRNAs and 13,585 coding transcripts. Results: We identified 608 up-regulated and 406 down-regulated lncRNAs in A-ED compared with NC samples, by setting a filter of fold-change >2.0. Gene Ontology and pathway analysis revealed that a muscle contraction disorder induced by abnormal ion channels might play a critical role in the pathogenesis of A-ED. Conclusion: Our results show significantly altered expression profiles of lncRNAs and mRNAs between A-ED and NC. This study may provide information for further research on A-ED and may be helpful for finding a new therapeutic target for A-ED.

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