The role of nitric oxide signaling in renoprotective effects of hydrogen sulfide against chronic kidney disease in rats: Involvement of oxidative stress, autophagy and apoptosis

2018 ◽  
Vol 234 (7) ◽  
pp. 11411-11423 ◽  
Author(s):  
Mohammad Khabbaz Shirazi ◽  
Asaad Azarnezhad ◽  
Mohammad Foad Abazari ◽  
Mansour Poorebrahim ◽  
Pegah Ghoraeian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Chronic Kidney Disease ◽  
Hydrogen Sulfide ◽  
Kidney Disease ◽  
Nitric Oxide Signaling

Ameliorative effects of hydrogen sulfide (NaHS) on chronic kidney disease-induced brain dysfunction in rats: implication on role of nitric oxide (NO) signaling

2018 ◽  
Vol 33 (6) ◽  
pp. 1945-1954 ◽  
Author(s):  
Hassan Askari ◽  
Mohammad Foad Abazari ◽  
Pegah Ghoraeian ◽  
Sepehr Torabinejad ◽  
Maryam Nouri Aleagha ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Kidney Disease ◽  
Hydrogen Sulfide ◽  
Kidney Disease ◽  
Brain Dysfunction ◽  
No Signaling

Role of matrix metalloproteinase-9 in chronic kidney disease: a new biomarker of resistant albuminuria

2016 ◽  
Vol 130 (7) ◽  
pp. 525-538 ◽  
Author(s):  
Helena Pulido-Olmo ◽  
Concha F. García-Prieto ◽  
Gloria Álvarez-Llamas ◽  
María G. Barderas ◽  
Fernando Vivanco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

Resistant albuminuria developed under chronic RAS blockade is strongly associated with increased circulating MMP-9 activity mediated by oxidative stress.

The role of oxidative stress in the development of protein-energy wasting and sarcopenia in patients with stage 5D chronic kidney disease

Nephrology ◽  
2021 ◽  
Vol 2_2021 ◽  
pp. 41-46
Author(s):  
M.Z. Gasanov Gasanov ◽  
V.M. Negoda Negoda ◽  
M.M. Batyushin Batyushin ◽  
◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Protein Energy Wasting ◽  
Protein Energy

Role of Uremic Toxins and Oxidative Stress in the Development of Chronic Kidney Disease–Mineral and Bone Disorder

2012 ◽  
Vol 22 (1) ◽  
pp. 98-101 ◽  
Author(s):  
Hisae Tanaka ◽  
Hirotaka Komaba ◽  
Masahiro Koizumi ◽  
Takatoshi Kakuta ◽  
Masafumi Fukagawa
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Uremic Toxins ◽  
Mineral And Bone Disorder ◽  
Bone Disorder ◽  
And Oxidative Stress

scholarly journals Role of gut-derived uremic toxins on oxidative stress and inflammation in patients with chronic kidney disease

2017 ◽  
Vol 27 (5) ◽  
pp. 359 ◽  
Author(s):  
P. V. L. N.Srinivasa Rao ◽  
S Gouroju ◽  
AR Bitla ◽  
KS Vinapamula ◽  
SM Manohar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Uremic Toxins

scholarly journals Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 752 ◽  
Author(s):  
Alina Podkowińska ◽  
Dorota Formanowicz
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Dysfunction ◽  
Acid Base ◽  
Excretory Function ◽  
Activation Of Transcription ◽  
Metabolic Products

Generating reactive oxygen species (ROS) is necessary for both physiology and pathology. An imbalance between endogenous oxidants and antioxidants causes oxidative stress, contributing to vascular dysfunction. The ROS-induced activation of transcription factors and proinflammatory genes increases inflammation. This phenomenon is of crucial importance in patients with chronic kidney disease (CKD), because atherosclerosis is one of the critical factors of their cardiovascular disease (CVD) and increased mortality. The effect of ROS disrupts the excretory function of each section of the nephron. It prevents the maintenance of intra-systemic homeostasis and leads to the accumulation of metabolic products. Renal regulatory mechanisms, such as tubular glomerular feedback, myogenic reflex in the supplying arteriole, and the renin–angiotensin–aldosterone system, are also affected. It makes it impossible for the kidney to compensate for water–electrolyte and acid–base disturbances, which progress further in the mechanism of positive feedback, leading to a further intensification of oxidative stress. As a result, the progression of CKD is observed, with a spectrum of complications such as malnutrition, calcium phosphate abnormalities, atherosclerosis, and anemia. This review aimed to show the role of oxidative stress and inflammation in renal impairment, with a particular emphasis on its influence on the most common disturbances that accompany CKD.

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