Roles of apoptotic chondrocyte‐derived CXCL12 in the enhanced chondroclast recruitment following methotrexate and/or dexamethasone treatment

Author(s):  
Yu‐Wen Su ◽  
Jian Fan ◽  
Chia‐Ming Fan ◽  
Yaser Peymanfar ◽  
Ya‐Li Zhang ◽  
...  
2001 ◽  
Vol 61 (9) ◽  
pp. 1101-1106 ◽  
Author(s):  
Ignacio Fajardo ◽  
Jose L Urdiales ◽  
Miguel A Medina ◽  
Francisca Sanchez-Jimenez

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 204
Author(s):  
Isabel M. Guijarro ◽  
Moisés Garcés ◽  
Pol Andrés-Benito ◽  
Belén Marín ◽  
Alicia Otero ◽  
...  

The actual role of prion protein-induced glial activation and subsequent cytokine secretion during prion diseases is still incompletely understood. The overall aim of this study is to assess the effect of an anti-inflammatory treatment with dexamethasone on different cytokines released by neuroglial cells that are potentially related to neuroinflammation in natural scrapie. This study emphasizes the complex interactions existent among several pleiotropic neuromodulator peptides and provides a global approach to clarify neuroinflammatory processes in prion diseases. Additionally, an impairment of communication between microglial and astroglial populations mediated by cytokines, mainly IL-1, is suggested. The main novelty of this study is that it is the first one assessing in situ neuroinflammatory activity in relation to chronic anti-inflammatory therapy, gaining relevance because it is based on a natural model. The cytokine profile data would suggest the activation of some neurotoxicity-associated route. Consequently, targeting such a pathway might be a new approach to modify the damaging effects of neuroinflammation.


Critical Care ◽  
2010 ◽  
Vol 14 (Suppl 1) ◽  
pp. P585
Author(s):  
SC Schuit ◽  
JJ Van Koesveld ◽  
AJ Bogers ◽  
J Bakker ◽  
RJ Van Thiel

2006 ◽  
Vol 43 (4) ◽  
pp. 809-815 ◽  
Author(s):  
Abbey Schepers ◽  
Nuno M.M. Pires ◽  
Daniel Eefting ◽  
Margreet R. de Vries ◽  
J. Hajo van Bockel ◽  
...  

The Lancet ◽  
2002 ◽  
Vol 360 (9328) ◽  
pp. 211-218 ◽  
Author(s):  
EM Molyneux ◽  
AL Walsh ◽  
H Forsyth ◽  
M Tembo ◽  
J Mwenechanya ◽  
...  

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