Development of a receptor-targeted gene delivery system using CXCR4 ligand-conjugated cross-linking peptides

The key strategy for the advancement of gene therapy is the development of an efficient targeted gene delivery system into cells. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relatively low transfection efficiency. It also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency. Also, the potential of clinical application was investigated.

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Development of a novel folic acid chitosan supported imidazole Schiff base for tumor targeted gene delivery system and drug therapy

Journal of Controlled Release ◽

10.1016/j.jconrel.2013.08.244 ◽

2013 ◽

Vol 172 (1) ◽

pp. e98 ◽

Cited By ~ 3

Author(s):

Bingyang Shi ◽

Mengjue Zhang ◽

Jingxiu Bi ◽

Sheng Dai

Keyword(s):

Schiff Base ◽

Folic Acid ◽

Drug Therapy ◽

Gene Delivery ◽

Delivery System ◽

Gene Delivery System ◽

Targeted Gene Delivery

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A promising targeted gene delivery system: Folate-modified dexamethasone-conjugated solid lipid nanoparticles

Pharmaceutical Biology ◽

10.3109/13880209.2013.876655 ◽

2014 ◽

Vol 52 (8) ◽

pp. 1039-1044 ◽

Cited By ~ 7

Author(s):

Wei Wang ◽

Fang Zhou ◽

Linfu Ge ◽

Ximin Liu ◽

Fansheng Kong

Keyword(s):

Gene Delivery ◽

Delivery System ◽

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Gene Delivery System ◽

Targeted Gene Delivery ◽

Solid Lipid

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Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In Vivo

Materials Science Forum ◽

10.4028/www.scientific.net/msf.539-543.641 ◽

2007 ◽

Vol 539-543 ◽

pp. 641-646 ◽

Cited By ~ 1

Author(s):

Tae Hee Kim ◽

Jin Hua ◽

Hyun Woo Kim ◽

Myung Haing Cho ◽

Jae Woon Nah ◽

...

Keyword(s):

Gene Delivery ◽

Delivery System ◽

Transfection Efficiency ◽

Viral Gene ◽

Gene Delivery System ◽

Targeted Gene Delivery ◽

Cell Specificity ◽

Selective Delivery

The development of an efficient targeted gene delivery system into cells is an important strategy for the advancement of gene therapy. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relative low transfection efficiency. And it also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency.

Download Full-text