scholarly journals Association between HIV PrEP indications and use in a national sexual network study of US men who have sex with men

2021 ◽  
Vol 24 (10) ◽  
Author(s):  
Kevin M. Weiss ◽  
Pragati Prasad ◽  
Travis Sanchez ◽  
Steven M. Goodreau ◽  
Samuel M. Jenness
Keyword(s):  
Sexual Network ◽  
Sex With Men

scholarly journals Sexual network characteristics of men who have sex with men with syphilis and/or gonorrhoea/chlamydia in Lima, Peru: network patterns as roadmaps for STI prevention interventions

2019 ◽  
Vol 95 (5) ◽  
pp. 336-341
Author(s):  
Cherie Blair ◽  
Ryan Colby Passaro ◽  
Eddy R Segura ◽  
Jordan E Lake ◽  
Amaya G Perez-Brumer ◽  
...  
Keyword(s):  
Network Size ◽  
Sexual Partners ◽  
Sexual Network ◽  
Syphilis Infection ◽  
Screening Process ◽  
Cross Sectional ◽  
Sti Prevention ◽  
Network Characteristics ◽  
Condomless Anal Intercourse ◽  
Sex With Men

ObjectiveWhile men who have sex with men (MSM) are disproportionately affected by Peru’s overlapping HIV and STI epidemics, there are few data on how partnership-level and network-level factors affect STI transmission in Peru. We explored partnership-level and network-level factors associated with gonorrhoea/chlamydia (Neisseria gonorrhoeae and/or Chlamydia trachomatis (NG/CT)) and/or syphilis infection among MSM in Peru.MethodsWe present the results of a cross-sectional secondary analysis of MSM (n=898) tested for syphilis and NG/CT infection as part of the screening process for two STI control trials in Lima, Peru. Participants completed questionnaires on demographics, sexual identity and role, characteristics of their three most recent sexual partners (partner sexual orientation, gender, role, partnership type, partner-specific sexual acts) and 30-day sexual network characteristics (number of sexual partners, partnership types, frequency of anal/vaginal intercourse). Participants were tested for syphilis and urethral, rectal and oropharyngeal NG/CT. Differences in network characteristics were analysed with χ2 and Kruskal-Wallis tests.ResultsApproximately 38.9% of participants had a new STI diagnosis (syphilis (rapid plasma reagin ≥16): 10.6%; NG/CT: 22.9%; syphilis-NG/CT coinfection: 5.4%). Condomless anal intercourse (CAI) was not significantly associated with an STI diagnosis. Gay-identified participants with exclusively homosexual networks had a higher prevalence of STIs (47.4%) than gay-identified MSM with only heterosexual/bisexual partners (34.6%, p=0.04), despite reporting fewer sexual partners (any partners: 2, 1–4 vs 3, 2–6; p=0.001; casual partners: 1, 0–3 vs 2, 1–4; p=0.001) and more stable partnerships (1, 0–1 vs 0, 0–1; p=0.003) in the last month.ConclusionsNetwork size and the number of casual sexual partners were associated with NG/CT infection among MSM in Peru. Despite reporting fewer sexual risk behaviours (smaller network size, more stable partnerships, less CAI), MSM with homosexual-only sexual networks had a higher prevalence of NG/CT and syphilis. These findings suggest network composition among MSM in Peru plays an important role in the risk for STI acquisition.

Risk behaviours of an interrelated syphilis-infected sexual network of men who have sex with men

2016 ◽  
Vol 25 (23-24) ◽  
pp. 3597-3604 ◽  
Author(s):  
Richie Diesterheft ◽  
John P Brady ◽  
Mona Shattell
Keyword(s):  
Risk Behaviours ◽  
Sexual Network ◽  
Sex With Men

scholarly journals Sexual network and detection of anogenital human papillomavirus in a community cohort of men who have sex with men in Taiwan

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0216784
Author(s):  
Carol Strong ◽  
Yi-Fang Yu ◽  
Huachun Zou ◽  
Wen-Wei Ku ◽  
Chia-Wen Lee ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Sexual Network ◽  
Sex With Men

scholarly journals Estimated Number of Men Who Have Sex With Men With Indications for HIV Pre-exposure Prophylaxis in a National Sexual Network Study

2020 ◽  
Vol 84 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Kevin M. Weiss ◽  
Pragati Prasad ◽  
Ramya Ramaraju ◽  
Maria Zlotorzynska ◽  
Samuel M. Jenness
Keyword(s):  
Sexual Network ◽  
Sex With Men ◽  
Exposure Prophylaxis

scholarly journals Disseminated Effects in Agent Based Models: A Potential Outcomes Framework and Application to Inform Pre-Exposure Prophylaxis Coverage Levels for HIV Prevention

2020 ◽  
Author(s):  
Ashley L Buchanan ◽  
S Bessey ◽  
William C Goedel ◽  
Maximilian King ◽  
Eleanor J Murray ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Hiv Incidence ◽  
Agent Based Models ◽  
Coverage Level ◽  
Sexual Network ◽  
Agent Based ◽  
Sex With Men ◽  
The Individual ◽  
Exposure Prophylaxis ◽  
Potential Outcomes Framework

Abstract Pre-exposure prophylaxis (PrEP) for HIV prevention may not only benefit the individual who uses it, but also their uninfected sexual risk contacts. We developed an agent-based model using a novel trial emulation approach to quantify disseminated effects of PrEP use among men who have sex with men in Atlanta, USA from 2015 to 2017. Components (subsets of agents connected through partnerships in a sexual network, but not sharing partnerships with any other agents) were first randomized to an intervention coverage level or control, then within intervention components, eligible agents were randomized to PrEP. We estimated direct and disseminated (indirect) effects using randomization-based estimators and reported corresponding 95% simulation intervals across scenarios ranging from 10% to 90% coverage in the intervention components. A population of 11,245 agents was simulated with an average of 1,551 components identified. Comparing agents randomized to PrEP in 70% coverage components to control agents, there was a 15% disseminated risk reduction in HIV incidence (95% simulation intervals = 0.65, 1.05). Individuals not on PrEP may receive a protective benefit by being in a sexual network with higher PrEP coverage. Agent-based models are useful to evaluate possible direct and disseminated effects of HIV prevention modalities in sexual networks.

scholarly journals Assessment of Bias in Estimates of Sexual Network Degree using Prospective Cohort Data

2019 ◽  
Author(s):  
Stephen Uong ◽  
Eli S. Rosenberg ◽  
Steven M. Goodreau ◽  
Nicole Luisi ◽  
Patrick Sullivan ◽  
...  
Keyword(s):  
Predictive Value ◽  
Prospective Cohort ◽  
Critical Role ◽  
Sensitivity Analyses ◽  
Sexual Network ◽  
Baseline Measure ◽  
Cross Sectional ◽  
Sti Prevention ◽  
Sexually Transmitted ◽  
Sex With Men

ABSTRACTBackgroundSexual network degree, a count of ongoing partnerships, plays a critical role in the transmission dynamics of human immunodeficiency virus (HIV) and other sexually transmitted infections (STI). Researchers often quantify degree using self-reported cross-sectional data on the day of survey, which may result in bias because of uncertainty about future sexual activity.MethodsWe evaluated the bias of a cross-sectional degree measure with a prospective cohort study of men who have sex with men (MSM). At baseline, we asked men about whether recent sexual partnerships were ongoing. We confirmed the true, ongoing status of those partnerships at baseline at follow-up. With logistic regression, we estimated the partnership-level predictors of baseline measure accuracy. With Poisson regression, we estimated the longitudinally confirmed degree as a function of baseline predicted degree.ResultsAcross partnership types, the baseline ongoing status measure was 70% accurate, with higher negative predictive value (91%) than positive predictive value (39%). Partnership exclusivity and racial pairing were associated with higher accuracy. Baseline degree generally overestimated confirmed degree. Bias, or number of ongoing partners different than predicted at baseline, was -0.28 overall, ranging from -1.91 to -0.41 for MSM with any ongoing partnerships at baseline. Comparing MSM of the same baseline degree, the level of bias was stronger for black compared to white MSM, and for younger compared to older MSM.ConclusionsResearch studies may overestimate degree when it is quantified cross-sectionally. Adjustment and structured sensitivity analyses may account for bias in studies of HIV or STI prevention interventions.

scholarly journals Association Between HIV PrEP Indications and Use in a National Sexual Network Study of Men Who Have Sex with Men

2021 ◽  
Author(s):  
Kevin M Weiss ◽  
Pragati Prasad ◽  
Travis Sanchez ◽  
Steven M Goodreau ◽  
Samuel M Jenness
Keyword(s):  
Hiv Transmission ◽  
Guideline Implementation ◽  
Sexual Network ◽  
Web Based ◽  
Preexposure Prophylaxis ◽  
Binomial Regression ◽  
Sex With Men ◽  
Using Data ◽  
The Relationship ◽  
Hiv Negative

BACKGROUND: HIV preexposure prophylaxis (PrEP) is effective in preventing HIV transmission. US Public Health Service (USPHS) clinical practice guidelines define biobehavioral indications for initiation. To assess guideline implementation, it is critical to quantify PrEP non-users who are indicated and PrEP users who are not indicated. METHODS: Using data from a national web-based study of men who have sex with men (MSM) between 2017 and 2019, we estimated the association between PrEP use and PrEP indications. Log-binomial regression was used to estimate the relationship between PrEP indications and PrEP use, adjusted for geography and demographics. RESULTS: Of 3508 sexually active, HIV-negative MSM, 34% met indications for PrEP. The proportion with current PrEP use was 32% among those meeting indications and 11% among those without indications. Nearly 40% of those currently using PrEP did not meet indications for PrEP, and 68% of MSM with indications for PrEP were not currently using PrEP. After adjusting for geography and demographics, MSM with PrEP indications were about 3 times as likely to be currently using PrEP. This association varied slightly by geography and demography. CONCLUSIONS: Indications for PrEP strongly predicted current PrEP use among MSM. However, we identified substantial misalignment between indications and use in both directions (indicated MSM who were not benefitting from PrEP, and MSM taking PrEP while not presently being indicated). This calls for further implementation efforts to improve PrEP delivery to those most in need during periods of elevated sexual risk.

scholarly journals Lymphogranuloma venereum in Australia

Sexual Health ◽  
2006 ◽  
Vol 3 (3) ◽  
pp. 131 ◽  
Author(s):  
Ian Simms ◽  
Helen Ward ◽  
Iona Martin ◽  
Sarah Alexander ◽  
Catherine Ison
Keyword(s):  
South America ◽  
Invasive Disease ◽  
Lymphogranuloma Venereum ◽  
Hiv Positive ◽  
Significant Morbidity ◽  
Tissue Destruction ◽  
Sexual Network ◽  
High Prevalence ◽  
The Caribbean ◽  
Sex With Men

Lymphogranuloma venereum (LGV), caused by C. trachomatis serovars L1, L2 and L3, is an invasive disease capable of causing tissue destruction with many patients experiencing complex, severe symptoms. LGV, endemic to areas of Africa, Asia, South America and the Caribbean, has emerged as a cause of significant morbidity among men who have sex with men (MSM) in more affluent nations. The high prevalence of HIV in LGV cases could suggest either that LGV is confined to a dense sexual network, or that clinicians are selectively testing HIV-positive MSM for LGV. The increase in reported LGV cases highlights the need to improve sexual health overall among MSM; experience from the recent syphilis outbreaks suggests that control could prove difficult.

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