Monitoring treatment response in patients undergoing chemoradiotherapy for locally advanced uterine cervical cancer by additional diffusion-weighted imaging: A systematic review

2014 ◽  
Vol 42 (3) ◽  
pp. 572-594 ◽  
Author(s):  
Sanne M. Schreuder ◽  
Rutger Lensing ◽  
Jaap Stoker ◽  
Shandra Bipat
Keyword(s):  
Systematic Review ◽  
Cervical Cancer ◽  
Treatment Response ◽  
Diffusion Weighted Imaging ◽  
Locally Advanced ◽  
Uterine Cervical Cancer ◽  
Diffusion Weighted ◽  
Monitoring Treatment ◽  
Monitoring Treatment Response

scholarly journals Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5748
Author(s):  
Maximilian Fleischmann ◽  
Georgios Chatzikonstantinou ◽  
Emmanouil Fokas ◽  
Jörn Wichmann ◽  
Hans Christiansen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Molecular Markers ◽  
Treatment Response ◽  
Locally Advanced ◽  
Therapy Response ◽  
Angiogenesis Inhibitors ◽  
Uterine Cervical Cancer ◽  
Cancer Pathogenesis ◽  
Primary Chemoradiotherapy ◽  
Related Mortality

Uterine cervical cancer is one of the leading causes of cancer-related mortality in women worldwide. Each year, over half a million new cases are estimated, resulting in more than 300,000 deaths. While less-invasive, fertility-preserving surgical procedures can be offered to women in early stages, treatment for locally advanced disease may include radical hysterectomy, primary chemoradiotherapy (CRT) or a combination of these modalities. Concurrent platinum-based chemoradiotherapy regimens remain the first-line treatments for locally advanced cervical cancer. Despite achievements such as the introduction of angiogenesis inhibitors, and more recently immunotherapies, the overall survival of women with persistent, recurrent or metastatic disease has not been extended significantly in the last decades. Furthermore, a broad spectrum of molecular markers to predict therapy response and survival and to identify patients with high- and low-risk constellations is missing. Implementation of these markers, however, may help to further improve treatment and to develop new targeted therapies. This review aims to provide comprehensive insights into the complex mechanisms of cervical cancer pathogenesis within the context of molecular markers for predicting treatment response and prognosis.

The feasibility of reduced field-of-view diffusion-weighted imaging in evaluating bladder invasion of uterine cervical cancer

2021 ◽  
Author(s):  
Mayumi Takeuchi ◽  
Kenji Matsuzaki ◽  
Masafumi Harada
Keyword(s):  
Cervical Cancer ◽  
Diffusion Weighted Imaging ◽  
False Positive Rate ◽  
Bladder Wall ◽  
Figo Stage ◽  
Uterine Cervical Cancer ◽  
Field Of View ◽  
Diffusion Weighted ◽  
Staging Accuracy ◽  
Bladder Invasion

Objectives: Uterine cervical cancer with bladder mucosal invasion is classified as FIGO stage IVA with poor prognosis. MRI can rule out the bladder invasion and skipping cystoscopy may be possible; however, high false-positive rate may be problematic. The purpose of this study is to evaluate the diagnostic performance of reduced field-of-view (FOV) diffusion-weighted imaging (DWI) in evaluating bladder mucosal invasion of cervical cancer. Methods: 3T MRI including T2WI and reduced FOV DWI in 15 women with histologically proven cervical cancer (two stage IIIB, six stage IVA, seven stage IVB) were retrospectively evaluated compared with cystoscopic findings. Results: Cystoscopy revealed mucosal invasion in 13 of 15 cases. The border between the tumor and the bladder wall was unclear on T2WI and clear on reduced FOV DWI in all 15 cases. The diagnosis of mucosal invasion on reduced FOV DWI had a sensitivity of 100%, specificity of 50%, accuracy of 93%, PPV of 93%, and NPV of 100%. Conclusions: Addition of reduced FOV DWI may improve the staging accuracy of MRI for cervical cancer in assessing the bladder mucosal invasion. Advances in knowledge: Reduced FOV DWI may improve the staging accuracy of cervical cancer in assessing bladder mucosal invasion with high NPV and PPV, which may be helpful for avoiding unnecessary cystoscopy.

scholarly journals Current Advances in the Application of Raman Spectroscopy for Molecular Diagnosis of Cervical Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Inês Raquel Martins Ramos ◽  
Alison Malkin ◽  
Fiona Mary Lyng
Keyword(s):  
Cervical Cancer ◽  
Raman Spectroscopy ◽  
Treatment Response ◽  
Molecular Diagnostics ◽  
Clinical Use ◽  
Structure Of Molecules ◽  
Diagnostic Potential ◽  
Monitoring Treatment ◽  
Monitoring Treatment Response

Raman spectroscopy provides a unique biochemical fingerprint capable of identifying and characterizing the structure of molecules, cells, and tissues. In cervical cancer, it is acknowledged as a promising biochemical tool due to its ability to detect premalignancy and early malignancy stages. This review summarizes the key research in the area and the evidence compiled is very encouraging for ongoing and further research. In addition to the diagnostic potential, promising results for HPV detection and monitoring treatment response suggest more than just a diagnosis prospective. A greater body of evidence is however necessary before Raman spectroscopy is fully validated for clinical use and larger comprehensive studies are required to fully establish the role of Raman spectroscopy in the molecular diagnostics of cervical cancer.

Reduced field-of-view diffusion-weighted MR imaging for assessing the local extent of uterine cervical cancer

2019 ◽  
Vol 61 (2) ◽  
pp. 267-275
Author(s):  
Mayumi Takeuchi ◽  
Kenji Matsuzaki ◽  
Yoshimi Bando ◽  
Masafumi Harada
Keyword(s):  
Cervical Cancer ◽  
Magnetic Resonance ◽  
Diffusion Weighted Imaging ◽  
Uterine Cervical Cancer ◽  
Field Of View ◽  
Resonance Imaging ◽  
Tumor Margins ◽  
Diffusion Weighted ◽  
Contrast Enhanced ◽  
Tumor Extent

Background Recently, the evaluation of the tumor size and local extension of early-stage uterine cervical cancer on magnetic resonance imaging is important for the accurate clinical staging and to determine the indication of less extensive surgery such as fertility sparing radical trachelectomy. Purpose To compare the diagnostic ability of reduced field-of-view diffusion-weighted imaging with those of three-dimensional (3D) contrast-enhanced T1-weighted imaging and T2-weighted imaging for assessing the tumor margin delineation and local extent of uterine cervical cancer. Material and Methods 3T magnetic resonance images, including T2-weighted imaging, reduced field-of-view diffusion-weighted imaging, and 3D contrast-enhanced T1-weighted imaging, in 27 women with surgically proven cervical cancer (19 FIGO stage IB1, 3 IB2, and 5 IIA1) were retrospectively evaluated. Tumor margins and local tumor extent, including the presence of invasion to parametrium and vagina were evaluated on both sagittal and oblique axial (short axis) images; the results were compared with histologically confirmed tumor extension. Results Reduced field-of-view diffusion-weighted imaging diagnosed the tumor margins, which was more accurate than T2-weighted imaging ( P<0.001) and slightly better than 3D contrast-enhanced T1-weighted imaging. Reduced field-of-view diffusion-weighted imaging could define the tumor margins well even in small lesions (≤ 20 mm). Histological examination revealed parametrial invasion in two cases (clinically under-staged) and vaginal invasion in four cases. Reduced field-of-view diffusion-weighted imaging could demonstrate local extension of all lesions, which was more accurate than clinical examination and T2-weighted imaging. Conclusion Addition of reduced field-of-view diffusion-weighted imaging may improve the staging accuracy of magnetic resonance imaging for cervical cancer in assessing the local tumor extent.

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