scholarly journals Editorial for “Traveling Volunteers – A Multi‐Vendor, Multi‐Center Study on Reproducibility and Comparability of 4D Flow Derived Aortic Hemodynamics in Cardiovascular Magnetic Resonance”

2021 ◽  
Author(s):  
Marko Boban
Keyword(s):  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
4D Flow ◽  
Multi Center Study ◽  
Aortic Hemodynamics ◽  
Center Study

scholarly journals Left atrial 4D flow cardiovascular magnetic resonance: a reproducibility study in sinus rhythm and atrial fibrillation

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Marco Spartera ◽  
Guilherme Pessoa-Amorim ◽  
Antonio Stracquadanio ◽  
Adam Von Ende ◽  
Alison Fletcher ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Pressure ◽  
Heart Rate ◽  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
Sinus Rhythm ◽  
Left Atrial ◽  
Peak Velocity ◽  
4D Flow ◽  
Mean Velocity

Abstract Background Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) allows sophisticated quantification of left atrial (LA) blood flow, and could yield novel biomarkers of propensity for intra-cardiac thrombus formation and embolic stroke. As reproducibility is critically important to diagnostic performance, we systematically investigated technical and temporal variation of LA 4D flow in atrial fibrillation (AF) and sinus rhythm (SR). Methods Eighty-six subjects (SR, n = 64; AF, n = 22) with wide-ranging stroke risk (CHA2DS2VASc 0–6) underwent LA 4D flow assessment of peak and mean velocity, vorticity, vortex volume, and stasis. Eighty-five (99%) underwent a second acquisition within the same session, and 74 (86%) also returned at 30 (27–35) days for an interval scan. We assessed variability attributable to manual contouring (intra- and inter-observer), and subject repositioning and reacquisition of data, both within the same session (same-day scan–rescan), and over time (interval scan). Within-subject coefficients of variation (CV) and bootstrapped 95% CIs were calculated and compared. Results Same-day scan–rescan CVs were 6% for peak velocity, 5% for mean velocity, 7% for vorticity, 9% for vortex volume, and 10% for stasis, and were similar between SR and AF subjects (all p > 0.05). Interval-scan variability was similar to same-day scan–rescan variability for peak velocity, vorticity, and vortex volume (all p > 0.05), and higher for stasis and mean velocity (interval scan CVs of 14% and 8%, respectively, both p < 0.05). Longitudinal changes in heart rate and blood pressure at the interval scan in the same subjects were associated with significantly higher variability for LA stasis (p = 0.024), but not for the remaining flow parameters (all p > 0.05). SR subjects showed significantly greater interval-scan variability than AF patients for mean velocity, vortex volume, and stasis (all p < 0.05), but not peak velocity or vorticity (both p > 0.05). Conclusions LA peak velocity and vorticity are the most reproducible and temporally stable novel LA 4D flow biomarkers, and are robust to changes in heart rate, blood pressure, and differences in heart rhythm.

Abstract 428: Progression Patterns of Carotid Atherosclerotic Plaques with and Without Intraplaque Hemorrhage Monitored for 6 Months: A Multicenter Magnetic Resonance Imaging Study

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
Jie Sun ◽  
Niranjan Balu ◽  
Dongxiang Xu ◽  
Daniel Hippe ◽  
Thomas Hatsukami ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Imaging Study ◽  
Carotid Bifurcation ◽  
Intraplaque Hemorrhage ◽  
Plaque Progression ◽  
Resonance Imaging ◽  
Lumen Volume ◽  
Multi Center Study ◽  
Center Study

Background: Carotid magnetic resonance imaging (MRI) is emerging as an effective tool for monitoring plaque progression noninvasively. However, data from multi-center studies are scarce. Intraplaque hemorrhage (IPH) has been shown to promote plaque growth. In this multi-center study over 6 months, we sought to study plaque progression in subjects with and without IPH. Methods: As the placebo arm of a multi-center clinical trial, 59 subjects with 16-79% carotid stenosis by ultrasound and a lipid core (LC) on baseline MRI completed a follow-up MRI at the end of a 6-month period. Thirty-nine (66.1%) were on concurrent rosuvastatin therapy. Lumen, wall and LC volumes, and IPH presence were measured on both scans blinded to time sequence at a core lab. Plaque progression was calculated as annualized changes within the common coverage between scans using the carotid bifurcation as a landmark. Results: IPH was present on 14 slices from 3 (5.1%) subjects at baseline. Subjects without IPH (n=56) showed a significant reduction in LC volume (p=0.031), a trend towards reduction in wall volume (p=0.215) and no apparent change in lumen volume (p=0.910). Although all subjects with IPH were on rosuvastatin during the study period, compared to subjects without IPH, they had increased LC (62.9±46.2 mm3/year vs. -8.8±29.9 mm3/year, p<0.001) and wall (100.1±78.1 mm3/year vs. -12.7±75.8 mm3/year, p=0.015) volumes, but decreased lumen volume (-93.4±114.7 mm3/year vs. 0.90±59.7 mm3/year, p=0.014). Conclusion: This multi-center study over 6 months demonstrated significant regression in LC volume in plaques without IPH. By contrast, plaques with IPH may be poorly controlled despite statin therapy.

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