Case report: Increased viral receptor expression associated with high viral load and severe pneumonia in a young patient infected with 2009 H1N1 influenza a with no pre-existing conditions

2012 ◽  
Vol 84 (3) ◽  
pp. 380-385 ◽  
Author(s):  
Chompunuch Boonarkart ◽  
Ratapum Champunot ◽  
Mongkol Uiprasertkul ◽  
Charatdao Bunthi ◽  
Sumalee Kiatboobsri ◽  
...  
Keyword(s):  
Case Report ◽  
Viral Load ◽  
Young Patient ◽  
Influenza A ◽  
Severe Pneumonia ◽  
High Viral Load ◽  
H1n1 Influenza ◽  
Receptor Expression ◽  
Viral Receptor ◽  
2009 H1n1

Epidemiological analysis of critically ill adult patients with pandemic influenza A(H1N1) in South Korea

2012 ◽  
Vol 141 (5) ◽  
pp. 1070-1079 ◽  
Author(s):  
S. B. HONG ◽  
E. Y. CHOI ◽  
S. H. KIM ◽  
G. Y. SUH ◽  
M. S. PARK ◽  
...  
Keyword(s):  
South Korea ◽  
Influenza A ◽  
Multivariate Logistic Regression Analysis ◽  
H1n1 Influenza ◽  
Epidemiological Analysis ◽  
Influenza A H1n1 ◽  
Failure Assessment ◽  
2009 H1n1 ◽  
Independent Risk Factors ◽  
Chronic Comorbidities

SUMMARYA total of 245 patients with confirmed 2009 H1N1 influenza were admitted to the intensive-care units of 28 hospitals (South Korea). Their mean age was 55·3 years with 68·6% aged >50 years, and 54·7% male. Nine were obese and three were pregnant. One or more comorbidities were present in 83·7%, and nosocomial acquisition occurred in 14·3%. In total, 107 (43·7%) patients received corticosteroids and 66·1% required mechanical ventilation. Eighty (32·7%) patients died within 30 days after onset of symptoms and 99 (40·4%) within 90 days. Multivariate logistic regression analysis showed that the clinician's decision to prescribe corticosteroids, older age, Sequential Organ Failure Assessment score and nosocomial bacterial pneumonia were independent risk factors for 90-day mortality. In contrast with Western countries, critical illness in Korea in relation to 2009 H1N1 was most common in older patients with chronic comorbidities; nosocomial acquisition occurred occasionally but disease in obese or pregnant patients was uncommon.

scholarly journals Subcutaneous Immunization with Baculovirus Surface-Displayed Hemagglutinin of Pandemic H1N1 Influenza A Virus Induces Protective Immunity in Mice

2011 ◽  
Vol 18 (9) ◽  
pp. 1582-1585 ◽  
Author(s):  
Mookkan Prabakaran ◽  
Tao Meng ◽  
Fang He ◽  
Tan YunRui ◽  
Jia Qiang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Protective Immunity ◽  
Influenza A ◽  
H1n1 Virus ◽  
H1n1 Influenza ◽  
Influenza Virus Hemagglutinin ◽  
Inactive Form ◽  
2009 H1n1 ◽  
Subcutaneous Immunization ◽  
H1n1 Virus Infection

ABSTRACTThe protective immunity of baculovirus displaying influenza virus hemagglutinin (BacHA) against influenza 2009 H1N1 virus infection in a murine model was investigated. The results showed that mice vaccinated with live BacHA or an inactive form of adjuvanted BacHA had enhanced specific antibody responses and induced protective immunity against 2009 H1N1 virus infection, suggesting the potential of baculovirus as a live or inactivated vaccine.

scholarly journals Higher Viral Load and Prolonged Viral Shedding Period is Associated with Impaired Th17 Cell Response in Patients with H1N1 Influenza A

2012 ◽  
Vol 1 (3) ◽  
pp. 137-145
Author(s):  
Gui-lin Yang ◽  
Ying-xia Liu ◽  
Mu-tong Fang ◽  
Wei-long Liu ◽  
Xin-chun Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Viral Load ◽  
Cell Response ◽  
Th17 Cell ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Cell Frequency ◽  
Viral Loads ◽  
Viral Shedding ◽  
Ifn Γ

Abstract Objective To explore whether age, disease severity, cytokines and lymphocytes in H1N1 influenza A patients correlate with viral load and clearance. Methods Total of 70 mild and 16 severe patients infected with H1N1 influenza A virus were enrolled in this study. Results It was found that the patients under 14 years old and severe patients displayed significantly higher viral loads and prolonged viral shedding periods compared with the patients over 14 years old and mild patients, respectively (P < 0.05). Moreover, the patients under 14 years old and severe patients displayed significantly lower Th17 cell frequency than the patients over 14 years old and mild patients (P < 0.01). The viral shedding period inversely correlated with the frequency of IL-17+IFN-γ-CD4+ T cells. Additionally, the decreased concentration of serum TGF-β correlated with the decreased frequency of IL-17+IFN-γ-CD4+ T cells. Conclusions Both younger and severe patients are associated with higher viral loads and longer viral shedding periods, which may partially be attributed to the impaired Th17 cell response.

scholarly journals Cross-Neutralizing Antibodies to Pandemic 2009 H1N1 and Recent Seasonal H1N1 Influenza A Strains Influenced by a Mutation in Hemagglutinin Subunit 2

2011 ◽  
Vol 7 (6) ◽  
pp. e1002081 ◽  
Author(s):  
Wei Wang ◽  
Christine M. Anderson ◽  
Christopher J. De Feo ◽  
Min Zhuang ◽  
Hong Yang ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Influenza A ◽  
H1n1 Influenza ◽  
2009 H1n1

scholarly journals A new common mutation in the hemagglutinin of the 2009 (H1N1) influenza A virus

PLoS Currents ◽  
2010 ◽  
Vol 2 ◽  
pp. RRN1162 ◽  
Author(s):  
Sebastian Maurer-Stroh ◽  
Raphael Tze Chuen Lee ◽  
Frank Eisenhaber ◽  
Lin Cui ◽  
Shiau Pheng Phuah ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Common Mutation ◽  
2009 H1n1

scholarly journals Inactivated pandemic 2009 H1N1 influenza A virus human vaccines have different efficacy after homologous challenge in the ferret model

2020 ◽  
Vol 15 (1) ◽  
pp. 142-153
Author(s):  
Beatriz Vidaña ◽  
Sharon M. Brookes ◽  
Helen E. Everett ◽  
Fanny Garcon ◽  
Alejandro Nuñez ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
H1n1 Influenza ◽  
2009 H1n1 ◽  
Homologous Challenge

Clinical Presentation of 2009 H1N1 Influenza A Disease in HIV-Infected Patients

2011 ◽  
Vol 19 (5) ◽  
pp. 340-342 ◽  
Author(s):  
Efrain Gonzalez ◽  
George Psevdos ◽  
Lia Tsveniashvili ◽  
Victoria Sharp
Keyword(s):  
Influenza A ◽  
Clinical Presentation ◽  
H1n1 Influenza ◽  
2009 H1n1

Prospective Evaluation of 2009 H1N1 Influenza A in Patients Admitted with Fever to an Oncology Unit

2011 ◽  
Vol 32 (8) ◽  
pp. 815-817 ◽  
Author(s):  
Karen Seiter ◽  
Dhaval Shah ◽  
Claudio Sandoval ◽  
Delong Liu ◽  
Robert B. Nadelman ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Infection Control ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Favorable Outcome ◽  
Prospective Evaluation ◽  
H1n1 Influenza Virus ◽  
Oncology Patients ◽  
2009 H1n1 ◽  
Oncology Unit

We prospectively evaluated all oncology inpatients for 2009 H1N1 influenza virus. All patients recovered completely. Evaluating all oncology patients with fever for influenza involved overtreatment of influenza-negative patients and involved a significant infection control burden. However, early antiviral intervention could have contributed to a favorable outcome.

scholarly journals Tropism of Pandemic 2009 H1N1 Influenza a Virus

2012 ◽  
Vol 3 ◽  
Author(s):  
Ririn Ramadhany ◽  
Mayo Yasugi ◽  
Shota Nakamura ◽  
Tomo Daidoji ◽  
Yohei Watanabe ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
H1n1 Influenza ◽  
2009 H1n1
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