CD4+ T cell count, HIV-1 viral loads and demographic variables of newly identified patients with HIV infection in Wuhan, China

Background: Serum cytokine levels over the course of HIV infection usually increase with immunosuppression and decrease after antiretroviral treatment (ART). Objectives: The aim of the study is to compare cytokine levels between HIV-infected patients (HIP) and controls and investigate the relationship between CD4+T cell count, HIV-RNA levels, and cytokine levels. Methods: The study subjects comprised ART-naive HIP (n=30) with no comorbidities and age-and sex-matched healthy controls. We measured levels of IL-6, IL-1β, TNF-α, and IFN-γ in serum samples of HIP at the beginning and at month 6 of ART and in controls. Results: The mean age of the study subjects was 38.7 ±10.3 years, with men making up 86.7% of the study subjects (n=26). IL-6, IL-1β, and TNF-α levels were significantly higher in both ART-naive (p<0.001, p=0.002, p=0.001) and ART-experienced HIP (p<0.001) than controls. The IFN-γ level was lower in both ART-naive and ART-experienced HIP compared to controls (p=0.082 and p=0.002). There was a positive correlation between the CD4+T cell count and serum concentration of IFN- γ(r=0.320, p<0.05). While the serum IFN-γ concentration showed a negative correlation with the HIVRNA level(r=-0.412, p<0.001), the serum IL-1β, IL-6, and TNF-α concentrations showed a positive correlation with the HIV-RNA level (r=0.349, p<0.001; r:0.54, p<0.001; r:0.438, p<0.00). Conclusions: Although serum concentrations of IL-6, IL-1β and TNF-α showed a significant decrease after ART, they were still significantly higher than the controls. IFN-γ responded differently to ART compared to the other cytokines, indicating that it may play a distinct and important role in the pathogenesis of HIV infection.

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T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART

AIDS ◽

10.1097/01.aids.0000247588.69438.fd ◽

2006 ◽

Vol 20 (16) ◽

pp. 2033-2041 ◽

Cited By ~ 72

Author(s):

Marco Marziali ◽

Wladimiro De Santis ◽

Rossella Carello ◽

Wilma Leti ◽

Antonella Esposito ◽

...

Keyword(s):

T Cell ◽

Cell Count ◽

Cd4 T Cell ◽

T Cell Homeostasis ◽

Cell Homeostasis ◽

Virus Load ◽

Hiv 1 ◽

Cd4 T Cell Count

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EBV AND HHV-6 CIRCULATING SUBTYPES IN PEOPLE LIVING WITH HIV IN BURKINA FASO, IMPACT ON CD4 T CELL COUNT AND HIV VIRAL LOAD

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2017.049 ◽

2017 ◽

Vol 9 (1) ◽

pp. 2017049 ◽

Cited By ~ 2

Author(s):

Lassina TRAORE ◽

Ouéogo NIKIEMA ◽

Abdoul Karim OUATTARA ◽

Tegwindé Rébéca COMPAORE ◽

Serge Théophile SOUBEIGA ◽

...

Keyword(s):

Viral Load ◽

T Cell ◽

Cell Count ◽

Cd4 Count ◽

Cd4 T Cell ◽

People Living With Hiv ◽

Study Population ◽

Living With Hiv ◽

Hiv 1 ◽

Cd4 T Cell Count

Epstein Barr Virus (EBV) and Human Herpes Virus 6 (HHV-6) are responsible for severe diseases, particularly in immunocompromised persons. There are poor data on the infection with these opportunistic viruses in Burkina Faso.The purpose of this study is to characterize EBV and HHV-6 subtypes and to assess their impact on CD4 T cell count, HIV-1 viral load and antiretroviral treatment in people living with HIV-1.The study population consisted of 238 HIV-positive patients with information on CD4 count, HIV-1 viral load and HAART. Venous blood samples collected on EDTA tubes were used for EBV and HHV-6 Real Time PCR subtyping.An infection rate of 6.7% (16/238) and 7.1% (17/238) were found respectively for EBV and HHV-6 in the present study. Among EBV infections, similar prevalences were noted for both subtypes (3.9% [9/238] for EBV-1 vs 4.6% [11/238] for EBV-2) with 2.1% (5/238) of co-infection. HHV-6A infection represented 6.3% (15/238) of the study population against 5.0% (12/238) for HHV-6B. . EBV-2 infection was significantly higher in patients with CD4 count ≥ 500 compared to those with CD4 count less than 500 cells (1.65% vs 8.56%, p = 0,011). The prevalence of EBV and HHV-6 infections were almost similar in HAART-naive and HAART-experienced patients.The present study provides information on the prevalence of EBV and HHV-6 subtypes in people living with HIV-1 in Burkina Faso. The study also suggests that HAART treatment has no effect on infection with these opportunistic viruses in people living with HIV-1.

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321. Low Volumetric Bone Density at Proximal Femur in HIV-Infected Men and Its Risk Factors: Comparison with Community-Dwelling Non-Infected Men

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.394 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S170-S170

Author(s):

Jung Ho Kim ◽

Namki Hong ◽

Woon Ji Lee ◽

Hye Seong ◽

Jin young Ahn ◽

...

Keyword(s):

Risk Factors ◽

T Cell ◽

Hiv Infection ◽

Protease Inhibitor ◽

Cell Count ◽

Community Dwelling ◽

Cd4 T Cell ◽

Total Hip ◽

Tertiary Center ◽

Cd4 T Cell Count

Abstract Background Individuals with HIV infection is at increased risk of low area bone mineral density (BMD) and fracture. However, data regarding volumetric BMD (vBMD) of central bone determined by quantitative computed tomography (QCT) which can distinguish the cortical and trabecular bone component are limited. Methods From November 2017 to October 2018, we measured spine and hip vBMD in HIV-infected men aged 30 years or older at the tertiary center. QCT data were compared with 1:2 matched control by age- and body mass index (BMI) sampled from a community-based healthy individual cohort. HIV-specific risk factors for low total hip vBMD as a primary outcome were identified using multivariate linear regression models. Results A total of 83 HIV-infected men and 166 control were analyzed (mean age 47.4 vs. 47.0 year; BMI 23.3 vs. 23.7 kg/m2; P > 0.05). In HIV-infected men, vBMD of trochanter, intertrochanter and total hip was significantly lower than that of non-infected men. (198 ± 31 vs. 213 ± 32; 339 ± 50 vs. 356 ± 47; 280 ± 41 vs. 296 ± 41 mg/cc; all P < 0.05) Association between HIV infection and lower total hip vBMD remained robust (Adjusted β -14.4; P = 0.013) after adjustment for age, diabetes, smoking, and vitamin D status. In HIV cohort, low CD4 T-cell count at initial diagnosis (< 200 vs. ≥200 cells/μL; Adjusted β = −6.7, P = 0.015) and use of protease inhibitor (vs. integrase inhibitor; Adjusted β = −29.9, P = 0.029) were negatively associated with total hip vBMD, after adjustment for age, BMI, and duration of HIV infection, whereas tenofovir disoproxil fumarate use was not. (Adjusted β −12.1, P = 0.280) In HIV-infected men with low tertile total hip vBMD, the levels of β-crosslaps (0.42 ± 0.23 vs. 0.30 ± 0.16 ng/mL; P = 0.012) and osteocalcin (22.10 ± 8.65 vs. 16.57 ± 6.04 ng/mL; P = 0.001) were higher than those with middle-upper tertile total hip vBMD. Conclusion HIV-infected men had lower hip vBMD compared with age- and BMI-matched non-infected men. Low baseline CD4 T-cell count and protease inhibitor use were independent risk factors for lower total hip vBMD. High born turnover was attributable to the negative effect on born health of HIV-infected men. Disclosures All authors: No reported disclosures.

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Close association of CD8+/CD38brightwith HIV-1 replication and complex relationship with CD4+T-cell count

Cytometry Part B Clinical Cytometry ◽

10.1002/cyto.b.20467 ◽

2009 ◽

Vol 76B (4) ◽

pp. 249-260 ◽

Cited By ~ 19

Author(s):

Edouard Tuaillon ◽

Yassine Al Tabaa ◽

Vincent Baillat ◽

Michel Segondy ◽

Marie-Christine Picot ◽

...

Keyword(s):

T Cell ◽

Cell Count ◽

Close Association ◽

Cd4 T Cell ◽

Complex Relationship ◽

Hiv 1 ◽

Cd4 T Cell Count

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CORRELATION OF HIV-1 P24 ASSAY WITH CD4 T-CELL COUNT, HIV, HBV AND HCV CO-INFECTIONS AND ITS IMPLICATION FOR ART MONITORING IN VASTLY HIV-INFECTED POPULATION OF NIGERIA

BMJ Global Health ◽

10.1136/bmjgh-2016-000260.87 ◽

2017 ◽

Vol 2 (Suppl 2) ◽

pp. A33.2-A34

Author(s):

Iheanyi Okonko ◽

Phillip Okerentugba ◽

Oluyinka Opaleye ◽

Ezinwanne Awujo ◽

Nnenna Frank-Peterside

Keyword(s):

T Cell ◽

Cell Count ◽

Cd4 T Cell ◽

Infected Population ◽

Hiv 1 ◽

Cd4 T Cell Count

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The Challenge of HIV-1 Genetic Diversity: Discordant CD4+ T-Cell Count and Viral Load in an Untreated Patient Infected With a Subtype F Strain

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/qai.0b013e3181b72539 ◽

2009 ◽

Vol 52 (5) ◽

pp. 659-661 ◽

Cited By ~ 8

Author(s):

Hector Bolivar ◽

Rebeca Geffin ◽

Gabriel Manzi ◽

Margaret A Fischl ◽

Vera Holzmayer ◽

...

Keyword(s):

Genetic Diversity ◽

Viral Load ◽

T Cell ◽

Cell Count ◽

Untreated Patient ◽

Cd4 T Cell ◽

Hiv 1 ◽

Cd4 T Cell Count

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The Relationship Between the Opportunistic Diseases and Viral Load and CD4+ T Cell Count in Patients With HIV Infection

Klimik Dergisi/Klimik Journal ◽

10.5152/kd.2015.06 ◽

2015 ◽

Vol 28 (1) ◽

pp. 28-34

Author(s):

Ahmet Cem Yardimci ◽

Muzaffer Fincanci

Keyword(s):

Viral Load ◽

T Cell ◽

Hiv Infection ◽

Cell Count ◽

Cd4 T Cell ◽

The Relationship ◽

Cd4 T Cell Count

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X4 Tropic Virus Prediction Is Associated with a Nadir CD4 T-Cell Count below 100 Cells/mm3

Intervirology ◽

10.1159/000398798 ◽

2015 ◽

Vol 58 (3) ◽

pp. 155-159 ◽

Cited By ~ 5

Author(s):

Matthieu Sechet ◽

Catherine Roussel ◽

Jean-Luc Schmit ◽

Carlo Saroufim ◽

Kamel Ghomari ◽

...

Keyword(s):

T Cell ◽

Cell Count ◽

False Positive Rate ◽

Cd4 T Cell ◽

Ccr5 Antagonist ◽

Net Charge ◽

Antagonist Therapy ◽

Hiv 1 ◽

Cd4 T Cell Count ◽

Tropism Prediction

Objective: The aim of this study was to evaluate tropism prediction performances of three algorithms [geno2pheno false-positive rate 10% (G2P10), position-specific scoring matrix (PSSM) and a combination of the 11/25 and net charge rules] and to investigate the viral and host factors potentially involved in the X4 or R5 prediction in human immunodeficiency virus-1 (HIV-1) patients. Methods: Viral tropism was determined in 179 HIV-1-infected patients eligible for CCR5 antagonist therapy. HIV-1 RNA or DNA was extracted and amplified for env gp120 sequencing. In parallel, demographic, viral, immunological and clinical determinants were analyzed. Results: According to the G2P10 algorithm, 48 patients harbored X4 or X4R5 virus. The tropism prediction was concordant for 87.7 and 88.2% of samples when comparing G2P10 with PSSM or with a combination of the 11/25 and net charge rules, respectively. X4 prediction was significantly associated with more than 35 amino acids in the V3 domain (p < 0.0001) and loss of an N-linked glycosylation site (p < 0.0001). Of the factors studied, only the nadir CD4 T-cell count was significantly associated with X4 tropism (p = 0.01). Conclusion: We determined that the X4 virus detection is closely linked to the nadir CD4 T-cell count below 100 cells/mm3 that must be taken into account when considering a CCR5 antagonist therapy switch.

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