Abstract. The aim of the study was to evaluate the relation between the Big Five personality traits and generalized self-efficacy. Data for the meta-analysis were collected from 53 studies, which included 60 independent samples, 188 effect sizes, and 28,704 participants. Lower neuroticism and higher extraversion, openness to experience, agreeableness, and conscientiousness were associated with greater generalized self-efficacy. Personality traits and generalized self-efficacy measurements, as well as age, moderated the relationship between the Big Five personality traits and generalized self-efficacy. The study extends current knowledge on the associations between personality traits and generalized self-efficacy.