In vivo versus in vitro polymerization of acrylic bone cement: Effect on material properties

In order to overcome the disadvantage of commercialized PMMA bone cement, we have developed novel PMMA-based bone cement(7P3S) reinforced by 30 wt.% of bioactive CaO-SiO2 gel powders to induce the bioactivity as well as to increase mechanical property for the PMMA bone cement. The novel 7P3S bone cement hardened after mixing for about 7 minutes. For in vitro evaluation, apatite forming ability of it was investigated using SBF. When the novel 7P3S bone cement was soaked into SBF, it formed apatite on its surfaces within 1 week Furthermore; there is no decrease in its compressive strength within 9 weeks soaking in SBF. It is though that hardly decrease in compressive strength of 7P3S bone cement in SBF is due to the relative small amount of gel powder or its spherical shape and monosize. In vivo evaluation of the novel 7P3S bone cement was carried out using rabbit. After implantion into rabbit tibia for several periods, the interface between novel bone cement and natural bone was evaluated by CT images. According to the results, the novel bone cement directly contact to the natural bone without fibrous tissue after implantation for 4 weeks. This results indicates that the newly developed 7P3S bone cement can bond to the living bone and also be effectively used as bioactive bone cement without decrease in mechanical property.

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Thermal Stress in Teeth

Journal of Dental Research ◽

10.1177/00220345780570040701 ◽

1978 ◽

Vol 57 (4) ◽

pp. 571-582 ◽

Cited By ~ 52

Author(s):

B.A. Lloyd ◽

M.B. McGinley ◽

W.S. Brown

Keyword(s):

Thermal Stress ◽

Numerical Analysis ◽

Material Properties ◽

Thermal Stresses ◽

In Vivo Studies ◽

Tooth Structure ◽

Analysis Techniques ◽

Tooth Type

Observations of crack damage in the tooth structure from in vivo studies and in vitro experimental thermal cycling studies were combined with numerical analysis techniques to identify and isolate the influence of thermal stresses an the creation and propagation of cracks in teeth. The factors considered in this study included: (a) variations in tooth type or geometry (molar, bicuspid, etc.), (b) tooth age, (c) material properties of the tooth, (d) the magnitude of the change in the temperature of the environment surrounding the tooth, and (e) the thermal resistance between the tooth and the medium surrounding the tooth.

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Droplet Based Measurements of Mechanical Forces and Material Properties, In Vivo and In Vitro

Biophysical Journal ◽

10.1016/j.bpj.2017.11.3596 ◽

2018 ◽

Vol 114 (3) ◽

pp. 666a

Author(s):

Elijah Shelton ◽

Adam Lucio ◽

Hannah Gustafson ◽

Alessandro Mongera ◽

Friedhelm Serwane ◽

...

Keyword(s):

Material Properties ◽

Mechanical Forces

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The chitosan/tri-calcium phosphate bio-composite bone cement promotes better osteo-integration: an in vitro and in vivo study

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-019-1201-2 ◽

2019 ◽

Vol 14 (1) ◽

Cited By ~ 4

Author(s):

Chih-Hsiang Fang ◽

Yi-Wen Lin ◽

Jui-Sheng Sun ◽

Feng-Huei Lin

Keyword(s):

Calcium Phosphate ◽

Bone Cement ◽

In Vivo Study ◽

Composite Bone

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Osseointegration of Antimicrobial Acrylic Bone Cements Modified with Graphene Oxide and Chitosan

Applied Sciences ◽

10.3390/app10186528 ◽

2020 ◽

Vol 10 (18) ◽

pp. 6528 ◽

Cited By ~ 2

Author(s):

Mayra Eliana Valencia Zapata ◽

José Herminsul Mina Hernandez ◽

Carlos David Grande Tovar ◽

Carlos Humberto Valencia Llano ◽

Blanca Vázquez-Lasa ◽

...

Keyword(s):

Graphene Oxide ◽

Bone Cement ◽

Orthopedic Surgery ◽

Bending Strength ◽

Orthopedic Implants ◽

Parietal Bone ◽

Maximum Temperature ◽

Cement Interface

Acrylic bone cement (ABC) is one of the most used materials in orthopedic surgery, mainly for the fixation of orthopedic implants to the bone. However, ABCs usually present lack of biological activity and osseointegration capacity that leads to loosening of the prosthesis. This work reports the effect of introducing graphene oxide (GO) and chitosan (CS), separately or together, in the ABC formulation on setting performance, mechanical behavior, and biological properties. Introduction of both CS and GO to the ABC decreased the maximum temperature by 21% and increased the antibacterial activity against Escherichia coli by 87%, while introduction of only CS decreased bending strength by 32%. The results of cell viability and cell adhesion tests showed in vitro biocompatibility. The in vivo response was investigated using both subdermal and bone parietal implantations in Wistar rats. Modified ABCs showed absence of immune response, as confirmed by a normal inflammatory response in Wistar rat subdermal implantation. The results of the parietal bone implantation showed that the addition of CS and GO together allowed a near total healing bone–cement interface, as observed in the micrographic analysis. The overall results support the great potential of the modified ABCs for application in orthopedic surgery mainly in those cases where osseointegration is required.

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