scholarly journals HIV-1 protein induced modulation of primary human osteoblast differentiation and function via a Wnt/β-catenin-dependent mechanism

2012 ◽  
Vol 31 (2) ◽  
pp. 218-226 ◽  
Author(s):  
Joseph S. Butler ◽  
Eilis C. Dunning ◽  
David W. Murray ◽  
Peter P. Doran ◽  
John M. O'Byrne
Keyword(s):  
Osteoblast Differentiation ◽  
Human Osteoblast ◽  
Primary Human Osteoblast ◽  
And Function ◽  
Hiv 1 ◽  
Dependent Mechanism

Stimulation of human osteoblast differentiation and function by ipriflavone and its metabolites

1994 ◽  
Vol 55 (5) ◽  
pp. 356-362 ◽  
Author(s):  
S. -L. Cheng ◽  
S. -F. Zhang ◽  
T. L. Nelson ◽  
P. M. Warlow ◽  
R. Civitelli
Keyword(s):  
Osteoblast Differentiation ◽  
Human Osteoblast ◽  
And Function ◽  
Stimulation Of

scholarly journals Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Joseph S Butler ◽  
Joseph M Queally ◽  
Brian M Devitt ◽  
David W Murray ◽  
Peter P Doran ◽  
...  
Keyword(s):  
Osteoblast Differentiation ◽  
Human Osteoblast ◽  
Primary Human Osteoblast ◽  
Dkk1 Expression

Anti-Osteoactivin Antibody Inhibits Osteoblast Differentiation and Function In Vitro

2003 ◽  
Vol 13 (2-4) ◽  
pp. 12 ◽  
Author(s):  
Abdulhafez A. Selim ◽  
Samir M. Abdelmagid ◽  
Reem A. Kanaan ◽  
Steven L. Smock ◽  
Thomas A. Owen ◽  
...  
Keyword(s):  
Osteoblast Differentiation ◽  
And Function

scholarly journals Calmodulin Regulates L-Selectin Adhesion Molecule Expression and Function through a Protease-Dependent Mechanism

Cell ◽  
1998 ◽  
Vol 92 (6) ◽  
pp. 809-818 ◽  
Author(s):  
Julius Kahn ◽  
Bruce Walcheck ◽  
Grace I Migaki ◽  
Mark A Jutila ◽  
Takashi Kei Kishimoto
Keyword(s):  
Adhesion Molecule ◽  
Adhesion Molecule Expression ◽  
And Function ◽  
Dependent Mechanism

scholarly journals The transcription factor osterix (SP7) regulates BMP6-induced human osteoblast differentiation

2012 ◽  
Vol 227 (6) ◽  
pp. 2677-2685 ◽  
Author(s):  
Fengchang Zhu ◽  
Michael S. Friedman ◽  
Weijun Luo ◽  
Peter Woolf ◽  
Kurt D. Hankenson
Keyword(s):  
Transcription Factor ◽  
Osteoblast Differentiation ◽  
Human Osteoblast

scholarly journals p27 regulates the autophagy-lysosomal pathway via the control of Ragulator and mTOR activity in amino acid deprived cells

2020 ◽  
Author(s):  
Ada Nowosad ◽  
Pauline Jeannot ◽  
Caroline Callot ◽  
Justine Creff ◽  
Renaud T. Perchey ◽  
...  
Keyword(s):  
Amino Acid ◽  
Energy Homeostasis ◽  
Underlying Mechanism ◽  
Mtor Inhibition ◽  
Mtorc1 Signaling ◽  
And Function ◽  
Mtorc1 Activation ◽  
Catabolic Process ◽  
Mtor Activity ◽  
Dependent Mechanism

SummaryAutophagy is a catabolic process whereby cytoplasmic components are degraded within lysosomes, allowing cells to maintain energy homeostasis during nutrient depletion. Several studies have shown that the CDK inhibitor p27Kip1 promotes starvation-induced autophagy. However, the underlying mechanism remains unknown. Here, we report that in amino acid deprived cells, p27 controls autophagy via an mTORC1-dependent mechanism. During prolonged amino acid starvation, a fraction of p27 is recruited to lysosomes where it interacts with LAMTOR1, a component of the Ragulator complex required for mTORC1 lysosomal localization and activation. p27 binding to LAMTOR1 prevents Ragulator assembly and function and subsequent mTORC1 activation, thereby promoting autophagy. Conversely, upon amino acid withdrawal, p27−/− cells exhibit elevated mTORC1 signaling, impaired lysosomal activity and autophagy, and resistance to apoptosis. This is associated with sequestration of TFEB in the cytoplasm, preventing the induction of lysosomal genes required for lysosomal function. Silencing of LAMTOR1 or mTOR inhibition restores autophagy and induces apoptosis in p27−/− cells. Together, these results reveal a direct, coordinated regulation between the cell cycle and cell growth machineries.

scholarly journals Human granulocyte-monocyte colony-stimulating factor and interleukin 3 stimulate monocyte cytotoxicity through a tumor necrosis factor- dependent mechanism

Blood ◽  
1988 ◽  
Vol 71 (3) ◽  
pp. 672-676
Author(s):  
SA Cannistra ◽  
E Vellenga ◽  
P Groshek ◽  
A Rambaldi ◽  
JD Griffin
Keyword(s):  
Tumor Necrosis Factor ◽  
Messenger Rna ◽  
Tumor Necrosis ◽  
Tumoricidal Activity ◽  
Interleukin 3 ◽  
Gm Csf ◽  
And Function ◽  
Monocyte Cytotoxicity ◽  
Necrosis Factor ◽  
Dependent Mechanism

Human colony-stimulating factors (CSF) exert multiple effects on the proliferation, differentiation, and function of myeloid lineage cells. In this study, the effects of three recombinant human CSFs (granulocyte- monocyte CSF [GM-CSF], interleukin 3 [IL-3], and granulocyte CSF [G- CSF]) on antibody-independent monocyte tumoricidal activity were investigated by using WEHI 164 fibrosarcoma cells as monocyte-sensitive targets. None of the CSFs directly induced monocyte cytotoxicity, although both GM-CSF and IL-3 were found to significantly enhance monocyte killing in response to a second stimulatory event (endotoxin). No effect was seen with G-CSF. Antitumor necrosis factor antibody completely abolished CSF-enhanced monocyte cytotoxicity, which suggests that this effect was mediated through increased release of tumor necrosis factor (TNF). As previously shown for GM-CSF, IL-3 was found to induce cytoplasmic accumulation of TNF messenger RNA (mRNA) after 18 hours of exposure. These results suggest that GM-CSF and IL-3 may stimulate monocyte killing indirectly by enhancing expression of TNF mRNA, thereby leading to augmented TNF protein secretion in response to a second activation signal.

Low intensity lasers differently induce primary human osteoblast proliferation and differentiation

2016 ◽  
Vol 163 ◽  
pp. 14-21 ◽  
Author(s):  
Flávia A. Oliveira ◽  
Adriana A. Matos ◽  
Mariana R. Santesso ◽  
Cintia K. Tokuhara ◽  
Aline L. Leite ◽  
...  
Keyword(s):  
Human Osteoblast ◽  
Osteoblast Proliferation ◽  
Low Intensity ◽  
Primary Human Osteoblast ◽  
Proliferation And Differentiation
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