Impact of a targeted volume increase nutrition guideline on growth and body mass index (BMI) in premature infants: A retrospective review

Author(s):  
Stephanie S Philip ◽  
Sarah E Davenport ◽  
Javed Mannan ◽  
Heather O White ◽  
Austin F Lee ◽  
...  
2020 ◽  
pp. archdischild-2019-318019
Author(s):  
Rajiv Sinha ◽  
Sushmita Banerjee ◽  
Anwesha Mukherjee ◽  
Shakil Akhtar ◽  
Subal Pradhan

BackgroundThere is scarcity of data on impact of rituximab on anthropometrical parameters (weight, height and body mass index i.e. BMI SD score (SDS)) among children with steroid-dependent nephrotic syndromes (SDNS).MethodsMulticentre retrospective review.Results102 children with SDNS (male: 63%; n=64), median age 7 (IQR: 4.3–9.6) years, received a total of 217 rituximab infusions (total 110 cycles). At median follow-up of 2.1 (IQR: 1.3–2.8) years, 58 (57%) children were off steroids and a significant fall in steroid threshold for relapse was noted (median 0.6; IQR 0.4–0.9 to median 0.3; IQR 0.12 - 0.5 mg/kg/alternate day, p=0.005). Anthropometric parameters (BMI SDS: 0.92±1.8 to 0.25±1.47, p=0.003; weight SDS: 0.20±1.6 to −0.11±1.3, p=0.01; and height SDS: −0.93±1.88 to −0.45±1.54, p=0.04) as well as obesity (38% to 20%, p=0.003) and short stature (11% to 3%, p=0.02) improved. Results remained significant even when analysis was restricted to children ≤12 years (n=88), (BMI SDS: 0.97±1.98 to 0.25±1.5, p=0.001; weight SDS: 0.33±1.6 to 0.02±1.2, p=0.01; and height SDS: −0.67±1.84 to −0.186±1.42, p=0.001).ConclusionsUse of rituximab resulted in significant steroid sparing effect with an improvement in both growth and obesity parameters.


Surgery ◽  
2017 ◽  
Vol 162 (6) ◽  
pp. 1320-1329 ◽  
Author(s):  
Lily Owei ◽  
Robert A. Swendiman ◽  
Rachel R. Kelz ◽  
Daniel T. Dempsey ◽  
Kristoffel R. Dumon

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
David T. Chao ◽  
Nilesh H. Shah ◽  
Herbert J. Zeh ◽  
Aatur D. Singhi ◽  
Nathan Bahary ◽  
...  

Background. Adolescent obesity is a national epidemic that recently has been shown to increase risk for pancreatic adenocarcinoma (PC) and is associated with an earlier age of PC onset. We hypothesized that PC patients who are overweight or obese at age 18 would have an earlier age of PC onset. Methods. Retrospective review of 531 patients in our PC registry was completed. Self-reported weight at age 18 and maximum lifetime weight were used to calculate body mass index (BMI) at age 18 (BMI-18) and maximum lifetime BMI. Results. Complete BMI and baseline covariate data was available in 319 PC patients. Mean age (in years) of PC diagnosis for patients whose BMI-18 was overweight (64.0) or obese (59.9) was significantly different when compared to patients with a normal BMI-18 (66.7). No significant difference was observed in the mean age of PC diagnosis in those patients who maintained a normal BMI-18 when compared to those patients who subsequently became overweight or obese (67.0 versus 66.6; p=0.65). Conclusions. An elevated BMI at age 18 is associated with an earlier age of PC onset and should be factored into determining the optimal age of beginning screening for patients at high risk for PC.


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