Infrared Absorption Ratio Method for Determination of Triethanolamine Salicylate in Ointment

The Absorption Ratio method involves measuring the absorbance at two wavelengths, namely the iso-absorptive point and the maximum wavelength. Its method could be an option in determining the level of a drug. The aim of this study was to determine whether the absorption ratio method can be used to determine the levels of paracetamol (PCT), propyphenazone (PRO) and caffeine (CAF) in tablet form. The absorption ratio method was used to determine the levels of the mixed drug compound without the separation stage and using the maximum wavelength and iso-absorptif point. The result of the study showed that the absorption ratio method used to solve multicomponent problems in tablet form can be performed and satisfy the validation requirements of the method according to international Conference on Harmonization Q2 (R1) (ICH) guidelines. The absorption ratio method was a simple and accurate to be used determine PCT, PRO, CAF in tablet form. Keywords : Paracetamol, propyphenazone, caffeine, absorption ratio

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Extractive Spectrophotometric Method for the Determination of Glibenclamide by Ion-Pair Complex in Pure Form and Pharmaceutical Formulation

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v9i3.20 ◽

2019 ◽

Vol 9 (o3) ◽

Author(s):

RUAA MUAYAD MAHMOOD ◽

HAMSA MUNAM YASSEN ◽

SAMAR , NAJWA ISSAC ABDULLA AHMED DARWEESH ◽

NAJWA ISSAC ABDULLA

Keyword(s):

Spectrophotometric Method ◽

Molar Absorptivity ◽

Ion Pair ◽

Pharmaceutical Formulation ◽

Ratio Method ◽

Colored Complex ◽

Colored Product ◽

Method Of Continuous Variation ◽

Job's Method

Simple, rapid and sensitive extractive spectrophotometric method is presented for the determination of glibenclamide (Glb) based on the formation of ion-pair complex between the Glb and anionic dye, methyl orange (MO) at pH 4. The yellow colored complex formed was quantitatively extracted into dichloromethane and measured at 426 nm. The colored product obeyed Beer’s law in the concentration range of (0.5-40) μg.ml-1. The value of molar absorptivity obtained from Beer’s data was found to be 31122 L.mol-1.cm-1, Sandell’s sensitivity value was calculated to be 0.0159 μg.cm-2, while the limits of detection (LOD) and quantification (LOQ) were found to be 0.1086 and 0.3292 μg.ml-1, respectively. The stoichiometry of the complex created between the Glb and MO was 1:1 as determined via Job’s method of continuous variation and mole ratio method. The method was successfully applied for the analysis of pharmaceutical formulation.

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Steel and iron. Determination of total carbon and sulfur content. Infrared absorption method after combustion in an induction furnace (routine method)

10.3403/02272084u ◽

2015 ◽

Cited By ~ 8

Keyword(s):

Sulfur Content ◽

Infrared Absorption ◽

Induction Furnace ◽

Total Carbon ◽

Absorption Method ◽

Routine Method ◽

Iron Determination

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The determination of hydroxyl by infrared absorption in quartz, silicate glasses and similar materials

Bulletin de Minéralogie ◽

10.3406/bulmi.1982.7582 ◽

1982 ◽

Vol 105 (1) ◽

pp. 20-29 ◽

Cited By ~ 239

Author(s):

Mervyn Silas Paterson

Keyword(s):

Infrared Absorption ◽

Silicate Glasses ◽

Similar Materials

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Comparative Study for the Assay of Plant Derived Chemicals in Pharmaceutical Formulation Using Methods Dependent on Factorized Spectra

Journal of AOAC International ◽

10.1093/jaoacint/qsab027 ◽

2021 ◽

Author(s):

Nesma M Fahmy ◽

Adel M Michael

Keyword(s):

Pharmaceutical Formulations ◽

Pharmaceutical Formulation ◽

Ternary Mixtures ◽

Ratio Method ◽

The Novel ◽

Naturally Occurring ◽

Accuracy And Precision ◽

Validation Parameters ◽

Significant Difference

Abstract Background Modern built-in spectrophotometer software supporting mathematical processes provided a solution for increasing selectivity for multicomponent mixtures. Objective Simultaneous spectrophotometric determination of the three naturally occurring antioxidants—rutin(RUT), hesperidin(HES), and ascorbic acid(ASC)—in bulk forms and combined pharmaceutical formulation. Method This was achieved by factorized zero order method (FZM), factorized derivative method (FD1M), and factorized derivative ratio method (FDRM), coupled with spectrum subtraction(SS). Results Mathematical filtration techniques allowed each component to be obtained separately in either its zero, first, or derivative ratio form, allowing the resolution of spectra typical to the pure components present in Vitamin C Forte® tablets. The proposed methods were applied over a concentration range of 2–50, 2–30, and 10–100 µg/mL for RUT, HES, and ASC, respectively. Conclusions Recent methods for the analysis of binary mixtures, FZM and FD1M, were successfully applied for the analysis of ternary mixtures and compared to the novel FDRM. All were revealed to be specific and sensitive with successful application on pharmaceutical formulations. Validation parameters were evaluated in accordance with the International Conference on Harmonization guidelines. Statistical results were satisfactory, revealing no significant difference regarding accuracy and precision. Highlights Factorized methods enabled the resolution of spectra identical to those of pure drugs present in mixtures. Overlapped spectra of ternary mixtures could be resolved by spectrum subtraction coupled FDRM (SS-FDRM) or by successive application of FZM and FD1M.

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Infrared Quantitative Analysis of Mixtures Containing Isopropenyl Stearate, Stearic Acid, Stearic Anhydride, and Mixed Stearic—Acetic Anhydride

Applied Spectroscopy ◽

10.1366/000370272774352434 ◽

1972 ◽

Vol 26 (1) ◽

pp. 96-99 ◽

Cited By ~ 1

Author(s):

Mary Jo Calhoun ◽

Edward S. DellaMonica

Keyword(s):

Acetic Anhydride ◽

Stearic Acid ◽

Relative Concentration ◽

Ternary Systems ◽

Spectral Interference ◽

Complex Mixtures ◽

Ratio Method ◽

Baseline Method ◽

Binary And Ternary Systems

A method for the determination of individual components of complex mixtures is presented. The technique used is based on ir-absorbance measurements for stearic acid at 1700 and at 935 cm−1 when the concentration range exceeds 0.50% wt/vol; for isopropenyl stearate at 1145 and at 865 cm−1; for stearic anhydride at 1030 cm−1 and mixed stearic-acetic anhydride at 1000 cm−1. The baseline method was used in all absorbance measurements. Absorbance-concentration relationships obeyed Beer's law from 0 to 2.0% wt/vol for most compounds; the exception being stearic acid (at 1700 cm−1), where linearity was limited to a maximum 0.50% wt/vol. Due to spectral interference between the two anhydrides at low concentration ratios, an empirical percent transmission ratio method was used to estimate the relative concentration of each. Binary and ternary systems were studied and the standard deviations of the differences between theoretical and calculated values indicate that this method is reliable.

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