Acetylsalicylic acid hydrolysis in aqueous solutions of polysorbate 80

1967 ◽  
Vol 56 (8) ◽  
pp. 1026-1027 ◽  
Author(s):  
K.S. Murthy ◽  
E.G. Rippie
Keyword(s):  
Aqueous Solutions ◽  
Acetylsalicylic Acid ◽  
Acid Hydrolysis ◽  
Polysorbate 80

Solubilization of Weakly Acidic and Basic Drugs by Aqueous Solutions of Polysorbate 80

1964 ◽  
Vol 53 (11) ◽  
pp. 1346-1348 ◽  
Author(s):  
E.G. Rippie ◽  
D.J. Lamb ◽  
P.W. Romig
Keyword(s):  
Aqueous Solutions ◽  
Polysorbate 80 ◽  
Basic Drugs

scholarly journals The dissociation constant and acid hydrolysis rate of hydroxysulfamic acid

1989 ◽  
Vol 67 (10) ◽  
pp. 1596-1598 ◽  
Author(s):  
David Littlejohn ◽  
Abigail R. Wizansky ◽  
S. G. Chang
Keyword(s):  
Aqueous Solutions ◽  
Acid Hydrolysis ◽  
Dissociation Constant ◽  
Acid Dissociation ◽  
Hydrolysis Rate ◽  
Acid Dissociation Constant

The acid dissociation constant and hydrolysis rate of hydroxysulfamic acid (HSA) in acid aqueous solutions have been studied. The acid dissociation constant was determined to be K = 1.5 ± 0.5 M at 298 K. The hydrolysis rate, R, was found to be R = k[H+][HSA], where k = 6.2 × 1012 exp (−26 300/RT) M−1 s−1 at (μ = 1.0 M and [HSA] is the concentration of all forms of hydroxysulfamic acid. Keywords: hydroxysulfamic acid, hydrolysis, acid dissociation.

Gravimetric Procedure for the Quantitation and Identification of Polysorbate 80 in Pickle Products

1967 ◽  
Vol 50 (6) ◽  
pp. 1265-1268
Author(s):  
Patricia Barcklow
Keyword(s):  
Fatty Acids ◽  
Infrared Spectroscopy ◽  
Petroleum Ether ◽  
Acid Hydrolysis ◽  
Polysorbate 80 ◽  
Silicotungstic Acid ◽  
Qualitative And Quantitative ◽  
Hydrolysis Of ◽  
Gravimetric Procedure

Abstract A qualitative and quantitative gravimetric procedure for Polysorbate 80 in pickle products involves acid hydrolysis of the comminuted sample, saponification, extraction of the glycol portion of the molecule with chloroform, and removal of interfering fatty acids with petroleum ether. The glycol is finally precipitated with silicotungstic acid, determined gravimetrically, and identified by infrared spectroscopy. Recoveries from commercially prepared pickle relish and dill pickles containing 0.01 to 0.02% Polysorbate 80 ranged from 80 to 98.5%

scholarly journals The Influence of UV Light on Photodegradation of Acetylsalicylic Acid

2021 ◽  
Vol 22 (8) ◽  
pp. 4046
Author(s):  
Monica Daescu ◽  
Miruna Iota ◽  
Constantin Serbschi ◽  
Alina C. Ion ◽  
Mihaela Baibarac
Keyword(s):  
Salicylic Acid ◽  
Solid State ◽  
Raman Scattering ◽  
Aqueous Solutions ◽  
Acetylsalicylic Acid ◽  
Ftir Spectroscopy ◽  
Phosphate Buffer ◽  
Uv Light ◽  
Band Intensity ◽  
Pl Spectra

Photodegradation of the aqueous solutions of acetylsalicylic acid, in the absence (ASA) and the presence of excipients (ASE), is demonstrated by the photoluminescence (PL). A shift of the PL bands from 342 and 338 nm to 358 and 361–397 nm for ASA and ASE in solid state and as aqueous solutions was reported. By exposure of the solution of ASA 0.3 M to UV light, a decrease in the PL band intensity was highlighted. This behavior was revealed for ASA in the presence of phosphate buffer (PB) having the pH equal to 6.4, 7, and 8 or by the interaction with NaOH 0.3 M. A different behavior was reported in the case of ASE. In the presence of PB, an increase in the intensity of the PL band of ASE simultaneously with a change of the ratio between the intensities of the bands at 361–364 and 394–397 nm was highlighted. The differences between PL spectra of ASA and ASE have their origin in the presence of salicylic acid (SAL). The interaction of ASE with NaOH induces a shift of the PL band at 405–407 nm. Arguments for the reaction of ASA with NaOH are shown by Raman scattering and FTIR spectroscopy.

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