The Application of Crown‐Chin Length to Crown‐Rump Length Ratio in Predicting Fetal Skeletal Dysplasia at First Trimester

Objective. The aim of this study was to evaluate the effectiveness of prenatal screening for trisomy 18 with the use of the frontomaxillary facial angle (FMF angle) measurement.Material and Methods. The study involved 1751 singleton pregnancies at 11–13 + 6 weeks, examined between 2007 and 2011. Serum PAPP-A and free beta-hCG levels were assessed, and crown-rump length, nuchal translucency, and FMF angle were measured in all patients. 1350 fetuses with known follow-up were included in the final analysis.Results. Highly significant (P<0.01) negative correlation between the CRL and the FMF angle was found. There were 30 fetuses with trisomy 18. FMF angle was highly significantly larger (P<0.0001) in fetuses with trisomy 18 as compared to chromosomally normal fetuses. Two models of first trimester screening were compared: Model 1 based on maternal age, NT, and first trimester biochemistry test (DR 80–85% and FPR 0.3–0.6%), and Model 2 = Model 1 + FMF angle measurement (DR 87.3–93.3% and FPR 0.8–1.3%).Conclusions. The use of FMF angle measurement increases the effectiveness of the screening for trisomy 18. Introduction of the FMF angle as an independent marker for fetal trisomy 18 risk requires further prospective research in large populations.

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Prediction of maturity in first trimester of pregnancy by ultrasonic measurement of fetal crown-rump length

Journal of Clinical Ultrasound ◽

10.1002/jcu.1870040204 ◽

1976 ◽

Vol 4 (2) ◽

pp. 83-84 ◽

Cited By ~ 21

Author(s):

A. Kurjak ◽

S. Cecuk ◽

B. Breyer

Keyword(s):

First Trimester ◽

Ultrasonic Measurement ◽

Crown Rump Length ◽

First Trimester Of Pregnancy

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First-trimester fetal growth discordance and development of preeclampsia in dichorionic twin pregnancies

Journal of Perinatal Medicine ◽

10.1515/jpm-2013-0260 ◽

2015 ◽

Vol 43 (6) ◽

Cited By ~ 1

Author(s):

Tanya Maric ◽

Natasha Singh ◽

Keith Duncan ◽

Guy J. Thorpe-Beeston ◽

Makrina D. Savvidou

Keyword(s):

Fetal Growth ◽

Case Control Study ◽

Subsequent Development ◽

First Trimester ◽

Case Control ◽

Retrospective Case ◽

Crown Rump Length ◽

Significant Difference ◽

Twin Pregnancies ◽

Control Study

AbstractTo investigate the relation between first-trimester fetal growth discrepancy, as assessed by crown-rump length (CRL) at 11+0 to 13+6 weeks of gestation, and subsequent development of preeclampsia (PE) in dichorionic diamniotic (DCDA) twin pregnancies. The association between inter-twin CRL and birth weight (BW) discrepancy was also investigated.This was a retrospective, case-control study of DCDA twin pregnancies. Inter-twin CRL discrepancy was calculated as 100×(larger CRL–smaller CRL)/larger CRL. BW discordance was calculated as 100×(larger BW–smaller BW)/larger BW.The study included 299 DCDA pregnancies that remained normotensive and 35 that subsequently developed PE. There was no significant difference in the inter-twin CRL discrepancy between pregnancies complicated by PE and those that were not [3.2%, interquartile range (IQR): 0.5–4.5% vs. 3.3%, IQR: 1.4–5.5%; P=0.17]. There was a positive correlation between inter-twin CRL and BW discrepancy but only in pregnancies that remained normotensive (P<0.001). In women that subsequently developed PE, there was no association between inter-twin CRL and BW discordance (P=0.54).In unselected DCDA twins, first-trimester CRL discrepancy is not different between pregnancies that subsequently develop PE and those that remain normotensive. Furthermore, in pregnancies that are complicated by PE, the association between inter-twin CRL and BW discrepancy appears to be lost.

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Three-dimensional ultrasound first trimester fetal volume measurement and its relation to pregnancy outcome

Journal of Perinatal Medicine ◽

10.1515/jpm-2016-0315 ◽

2017 ◽

Vol 45 (9) ◽

Author(s):

Haitham A. Torky ◽

Asem A. Moussa ◽

Ali M. Ahmad ◽

Osama Dief ◽

Manar A. Eldesoouky ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pregnancy Outcome ◽

Gestational Age ◽

Preterm Labor ◽

Three Dimensional ◽

First Trimester ◽

3D Ultrasound ◽

Secondary Outcome ◽

Crown Rump Length

AbstractAim of work:To determine whether fetal volume (FV) measured by three-dimensional (3D) ultrasound was able to detect fetuses at risk of low birth weight (primary outcome) and/or preterm labor (secondary outcome).Methods:One hundred pregnant women carrying a singleton living pregnancy who were sure of dates, and had a dating scan, with gestational age between 11 weeks and 13 weeks+6 days coming for routine first trimester nuchal translucency (NT) were examined by both two-dimensional (2D) and 3D ultrasound (Vocal System) for crown-rump length (CRL) and FV then followed up regularly every 4 weeks until 28 weeks then biweekly until 36 weeks then weekly until delivery both clinically and by ultrasound biometry.Findings:Eighty-seven cases had a normal outcome, while the remaining 13 cases had either preterm labor (four cases) or low-birth weight (nine cases). FV positively correlated with CRL (P=0.026), gestational age in weeks (P=0.002), neonatal body weight in grams (P=0.018) and neonatal body length at birth (P=0.04). A mean FV of 8.3 mmConclusion:3D assessment of FV in the first trimester provides an accurate method for predicting pregnancy outcome namely low birth weight and neonatal complications, however, it is a better positive predictor than a negative one.

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Ultrasound Assessment of Twin Reversed Arterial Perfusion Sequence for the Prediction of Adverse Pregnancy Outcomes in the First Trimester

10.21203/rs.3.rs-142998/v1 ◽

2021 ◽

Author(s):

Ying Tang ◽

Yan Zeng ◽

Taizhu Yang ◽

Pan Yang ◽

Shan Bao ◽

...

Keyword(s):

Gestational Age ◽

Pregnancy Outcomes ◽

First Trimester ◽

Adverse Pregnancy Outcomes ◽

University Hospital ◽

Intrauterine Death ◽

Crown Rump Length ◽

Arterial Perfusion ◽

Adverse Pregnancy ◽

Twin Reversed Arterial Perfusion

Abstract ObjectivesTo investigate twin reversed arterial perfusion (TRAP) sequence for the prediction of TRAP-related adverse pregnancy outcomes at the gestational age of 11-14 weeks. MethodsPregnant women in the first trimester diagnosed with TRAP were recruited at West China Second University Hospital from January 2015 to June 2018. Systematic screening for the pump twin’s crown-rump length (CRL) and acardiac twin’s upper pole-rump length (URL) was conducted using ultrasonic detection. The (CRL-URL)/CRL and URL/CRL ratios were used to assess the pregnancy outcomes for the pump twin. ResultsTwenty-one pregnant women aged 21–39 years with a gestation of 11-14 weeks were recruited. TRAP was diagnosed on average (± standard deviation [SD]) at pregnancy week 13.1 ± 0.18. The pump twins’ mean (± SD) CRL was 6.65 ± 1.1 cm. The incidence of intrauterine death for the pump twins was 19.0% (n=4), the miscarriage rate was 14.3% (n=3), and the live birth rate was 66.7% (n=14). The (CRL-URL)/CRL ratios between the non-survival (intrauterine death and miscarriage) and survival groups significantly differed (0.33 ± 0.08 vs. 0.58 ± 0.08, p < 0.05). Similarly, the URL/CRL ratios between the non-survival and survival groups significantly differed (0.67 ± 0.08 vs. 0.42 ± 0.08, p < 0.05). ConclusionsThe (CRL-URL)/CRL and URL/CRL ratios were valuable indicators for determining pregnancy outcomes of pump twins with TRAP at an early gestational age.

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P07.17: The use of first trimester biochemical markers for crown-rump length quality control

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.11855 ◽

2012 ◽

Vol 40 (S1) ◽

pp. 197-197 ◽

Cited By ~ 1

Author(s):

J. Sabria ◽

E. Sabrià ◽

A. Borrell ◽

R. Navarro ◽

M. Gómez Roig ◽

...

Keyword(s):

Quality Control ◽

Biochemical Markers ◽

First Trimester ◽

Crown Rump Length

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First‐Trimester Abdominal Circumference (Versus Crown Rump Length) Improves Precision in Inter‐ and Intraobserver Variability

Journal of Ultrasound in Medicine ◽

10.1002/jum.14913 ◽

2018 ◽

Vol 38 (8) ◽

pp. 2161-2167 ◽

Cited By ~ 1

Author(s):

Yalda Afshar ◽

Rachel Gutkin ◽

Deborah Krakow ◽

Howard Cuckle ◽

Neil S. Silverman ◽

...

Keyword(s):

First Trimester ◽

Abdominal Circumference ◽

Intraobserver Variability ◽

Crown Rump Length

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First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population

Obstetrics and Gynecology International ◽

10.1155/2014/435037 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Cláudia Teixeira ◽

Eduardo Tejera ◽

Helena Martins ◽

António Tomé Pereira ◽

Altamiro Costa-Pereira ◽

...

Keyword(s):

Logistic Regression ◽

Late Onset ◽

Screening Program ◽

First Trimester ◽

University Hospital ◽

Aneuploidy Screening ◽

Detection Rates ◽

Crown Rump Length ◽

Screening Programs ◽

Obstetric Population

Objective. To evaluate the performance of a first trimester aneuploidy screening program for preeclampsia (PE) prediction in a Portuguese obstetric population, when performed under routine clinical conditions.Materials and Methods. Retrospective cohort study of 5672 pregnant women who underwent routine first trimester aneuploidy screening in a Portuguese university hospital from January 2009 to June 2013. Logistic regression-based predictive models were developed for prediction of PE based on maternal characteristics, crown-rump length (CRL), nuchal translucency thickness (NT), and maternal serum levels of pregnancy-associated plasma protein-A (PAPP-A) and free beta-subunit of human chorionic gonadotropin (freeβ-hCG).Results. At a false-positive rate of 5/10%, the detection rate for early-onset (EO-PE) and late-onset (LO-PE) PE was 31.4/45.7% and 29.5/35.2%, respectively. Although both forms of PE were associated with decreased PAPP-A, logistic regression analysis revealed significant contributions from maternal factors, freeβ-hCG, CRL, and NT, but not PAPP-A, for prediction of PE.Conclusion. Our findings support that both clinical forms of EO-PE and LO-PE can be predicted using a combination of maternal history and biomarkers assessed at first trimester aneuploidy screening. However, detection rates were modest, suggesting that models need to be improved with additional markers not included in the current aneuploidy screening programs.

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