scholarly journals Safety and efficacy of cryolipolysis for non‐invasive reduction of submental fat

2015 ◽  
Vol 48 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Suzanne L. Kilmer ◽  
A. Jay Burns ◽  
Brian D. Zelickson
Keyword(s):  
Safety And Efficacy ◽  
Non Invasive ◽  
Submental Fat

Abstract 15821: Safety and Efficacy of Non-invasive Ventilation During Exercise Training in Patients With Acute Heart Failure. A Randomized Prospective Controlled Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Mayron F Oliveira ◽  
Rita L Santos ◽  
Vanessa M Mendez ◽  
Priscila A Sperandio ◽  
Iracema I Umeda ◽  
...  
Keyword(s):  
Heart Failure ◽  
Exercise Training ◽  
Adverse Events ◽  
Hospital Stay ◽  
Length Of Hospital Stay ◽  
Invasive Ventilation ◽  
Serious Adverse Events ◽  
Safety And Efficacy ◽  
Non Invasive ◽  
Non Invasive Ventilation

Background: Exercise training (ET) is well established to improve functional capacity and quality of life in patients (pts) with chronic heart failure. However, the ET benefits in acute heart failure (AHF) are unknown. Purpose: We aimed to study the safety and efficacy of ET alone or combined with non-invasive ventilation (NIV) compared to standard medical treatment in hospitalized pts with AHF. Methods: Twenty-nine pts with AHF (68% ischemic), 56±7 years, left ventricle ejection fraction of 25±5%, NTproBNP of 2456±730, 6-minute walk test distance (6MWD = 225±39meters) were randomized into 3 groups: ET + NIV with sub therapeutic positive airway pressure (PAP) (ET,n=9), ET + NIV set to 14 of inspiratory and 8 cmH2O of expiratory PAP, respectively (EV,n=11) and standard treatment (CO,n=9). The ET and EV groups performed a daily session of unloaded exercise on cycle ergometer for 20 min or tolerance limit, for 8 consecutives days. In EV and ET, oxygen pulse saturation (SpO2), heart rate (HR), respiratory rate (RR), blood pressure (BP), blood lactate were measured at baseline (D1), during exercise, and at day 10 (D10). Serious adverse events (death or worsening heart failure) were also assessed on D10. Results: Length of hospital stay was shorter in EV group (17±10 days) compared to ET (23±8 days) and CO (39±15 days) (p<0,05). There were more serious adverse events in CO (66,6%) compared to both EV and ET (15%). Dobutamine use at D10 was less frequent in EV (18,2%) and ET (22,2%) groups than in CO (33,3%) (p<0.05). There was a marked improvement in Δ6MWD between D1 and D10 in EV (Δ127±72 meters), though increase in Δ6MWD was also seen in ET (Δ72±26 meters) and CO (Δ41±19meters), p<0,05. The EV group also showed higher endurance and lower peak HR at end-exercise than ET at D10 (128±10 vs. 92±8 min and 73±12 vs. 104±25 bpm, respectively; p<0,05). There was a similar reduction in NTproBNP levels but no differences were found in BP, SpO2, RR and blood lactate. Conclusion: Aerobic exercise in AHF was safe, reduced length of hospital stay and need for inotropics at D10. NIV + ET increased exercise endurance with lower cardiovascular stress.

scholarly journals Non-Invasive Ventilation: a Safe and Effective Respiratory Support Method in Hypoxemic Acute Respiratory Failure Due to Pneumonia with or without Acute Respiratory Distress Syndrome

Folia Medica ◽  
2021 ◽  
Vol 63 (3) ◽  
pp. 321-328
Author(s):  
Viktoria Ilieva ◽  
Yordanka Yamakova
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Respiratory Support ◽  
Invasive Ventilation ◽  
Safety And Efficacy ◽  
Non Invasive ◽  
Non Invasive Ventilation

Introduction: The benefit of non-invasive ventilation (NIV) in cases of hypercapnic acute respiratory failure (ARF) has already been proven. Still, its safety and efficacy as a respiratory support method for patients with hypoxemic ARF hasn&rsquo;t been studied so well.Aim: The aim of our study was to examine the safety and efficacy of NIV in hypoxemic ARF of primary lung origin.Materials and methods: This was a prospective observational cohort study of patients with hypoxemic ARF due to communityacquired pneumonia with or without acute respiratory distress syndrome (ARDS) treated using NIV. They were divided into four groups: pneumonia without ARDS, mild, moderate, or severe ARDS. Their clinical and ABG parameters were recorded before initiation of NIV, at 1 hour and 24 hours after ventilation onset and at transition to non-intensive NIV or before endotracheal intubation in NIV failure cases.Results: A total of 63 patients were included. NIV trial was successful in 85.71% of them, while 14.29% experienced NIV failure. In the general population, we observed a significant difference in PaO2/FiO2 only before transition to non-intensive NIV in comparison to the value at admission. This trend was seen in the patients with pneumonia without ARDS and moderate ARDS, but not in those with mild and severe ARDS. The clinical parameters showed improvement early in the course of treatment both in the entire study population and all subgroups.Conclusions: NIV is an effective and safe option for respiratory support in patients with severe CAP only when an adequate etiological treatment has been applied.

scholarly journals Clinical Evaluation of the Safety and Efficacy of a 1060-nm Diode Laser for Non-Invasive Fat Reduction of the Abdomen

2021 ◽  
Author(s):  
Mikaela Kislevitz ◽  
Christine Wamsley ◽  
Alison Kang ◽  
Suzanne Kilmer ◽  
John Hoopman ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Diode Laser ◽  
Treatment Protocol ◽  
Post Treatment ◽  
Ultrasound Images ◽  
Level Of Evidence ◽  
Safety And Efficacy ◽  
Non Invasive ◽  
Fat Reduction

Abstract Background Despite the proven efficacy of liposuction, there is a population of patients who prefer non-surgical alternatives. Laser hyperthermia-induced lipolysis has emerged as one non-invasive alternative to liposuction. Objectives The authors sought to evaluate the safety and efficacy of a 1060-nm (±10 nm) diode laser for non-invasive fat reduction of the abdomen. Methods This single-arm, 2-center study enrolled 30 patients. Patients received a 25-minute 1060-nm diode laser treatment on their abdomen. Ultrasound adipose measurements, body weight, and circumference were taken at baseline and at 6- and 12-week follow-up visits. Blinded evaluators identified “before” and “after” photos of each patient. A patient satisfaction questionnaire was completed by each patient at study exit. Results A total 29 patients completed all treatment and follow-up visits. Ultrasound images showed an adipose reduction of 8.55% at 12 weeks post-treatment (P &lt; 0.0001). Blinded evaluators correctly identified 67% of the pre- and post-treatment images at site 01 (Sacramento, CA) and 56% at site 02 (Dallas, TX). Satisfaction was high, with 72% of patients reporting being either “satisfied” or “very satisfied” with their results on a 5-point Likert scale. Pain was rated as mild by 62% of patients, moderate by 38%, and severe by none on the Wong-Baker Scale. Conclusions These results indicate that a single treatment with a 1060-nm (±10 nm) diode laser, per the treatment protocol, is safe and effective in reducing unwanted fat in the abdomen as objectively measured employing ultrasound. The treatment was well-tolerated among all patients, with minimal discomfort reported and high patient satisfaction. Level of Evidence: 4

scholarly journals Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial

The Lancet ◽  
2011 ◽  
Vol 378 (9802) ◽  
pp. 1547-1559 ◽  
Author(s):  
Zahi A Fayad ◽  
Venkatesh Mani ◽  
Mark Woodward ◽  
David Kallend ◽  
Markus Abt ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Multimodality Imaging ◽  
Randomised Clinical Trial ◽  
Atherosclerotic Disease ◽  
Safety And Efficacy ◽  
Non Invasive

scholarly journals Osteopathic Manipulative Treatments for Pediatric Conditions

2020 ◽  
pp. 25-29
Author(s):  
Selena Raines ◽  
Amanda Ramey
Keyword(s):  
Otitis Media ◽  
Chronic Condition ◽  
Pediatric Patients ◽  
Statistical Significance ◽  
Daily Practice ◽  
Outpatient Setting ◽  
Osteopathic Manipulative Treatment ◽  
Safety And Efficacy ◽  
Non Invasive ◽  
Children With Asthma

Osteopathic manipulative treatment (OMT) has been used in the treatment of pediatric patients for decades. The authors performed a systematic review to find evidence showing the safety and efficacy of OMT use in pediatric patients for common pediatric conditions seen in the outpatient setting. The conditions reviewed are otitis media and asthma, as they are the most common acute reason children under age five present to their physician and the most common chronic condition affecting children, respectively. The review found evidence of OMT being beneficial in the reduction of middle ear effusions following otitis media. The use of OMT was also shown to increase the peak expiratory flow of children with asthma. Very few studies have been performed to show the safety of osteopathic manipulative treatment; however one study showed that the incidence of iatrogenesis is minimal. Several easy-to-use techniques are demonstrated in the hopes that this will encourage more osteopathic physicians to incorporate the use of OMT into daily practice. As it stands, more studies are needed to give statistical significance and to prove that OMT is a safe, effective, non-invasive option for the treatment of various pediatric conditions.

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