PKCα in colon cancer cells promotes M1 macrophage polarization via MKK3/6-P38 MAPK pathway

2018 ◽  
Vol 57 (8) ◽  
pp. 1017-1029 ◽  
Author(s):  
Yang Cheng ◽  
Yun Zhu ◽  
Wanfu Xu ◽  
Jiajia Xu ◽  
Min Yang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Macrophage Polarization ◽  
Colon Cancer Cells ◽  
P38 Mapk Pathway ◽  
M1 Macrophage

Taiwanin E inhibits cell migration in human LoVo colon cancer cells by suppressing MMP-2/9 expression via p38 MAPK pathway

2016 ◽  
Vol 32 (8) ◽  
pp. 2021-2031 ◽  
Author(s):  
Hsi-Hsien Hsu ◽  
Wei-Wen Kuo ◽  
Cecilia Hsuan Day ◽  
Marthandam Asokan Shibu ◽  
Shin-Yi Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Colon Cancer Cells ◽  
P38 Mapk Pathway

Tectoridin inhibits the progression of colon cancer through downregulating PKC/p38 MAPK pathway

2021 ◽  
Author(s):  
Lingfan Xiong ◽  
Wenhao Guo ◽  
Yong Yang ◽  
Danping Gao ◽  
Jun Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
P38 Mapk Pathway

scholarly journals Pramanicin Analog Induces Apoptosis in Human Colon Cancer Cells: Critical Roles for Bcl-2, Bim, and p38 MAPK Signaling

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56369 ◽  
Author(s):  
Cagri Bodur ◽  
Ozgur Kutuk ◽  
Gizem Karsli-Uzunbas ◽  
Tayirjan T. Isimjan ◽  
Paul Harrison ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Human Colon ◽  
Mapk Signaling ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153

Neoplasma ◽  
2011 ◽  
Vol 58 (6) ◽  
pp. 482-490 ◽  
Author(s):  
N. WU ◽  
C. GU ◽  
H. GU ◽  
H. HU ◽  
Y. HAN ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Lung Cancer Cells ◽  
P38 Mapk Pathway

scholarly journals Proteasome Inhibition Induces a p38 MAPK Pathway-Dependent Antiapoptotic Program via Nrf2 in Thyroid Cancer Cells

Endocrinology ◽  
2011 ◽  
Vol 152 (4) ◽  
pp. 1722-1724
Author(s):  
Zhen-Xian Du ◽  
Ying Yan ◽  
Hai-Yan Zhang ◽  
Bao-Qin Liu ◽  
Yan-Yan Gao ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Clinical Endocrinology ◽  
Proteasome Inhibition ◽  
P38 Mapk Pathway ◽  
Thyroid Cancer Cells

This article appears in The Journal of Clinical Endocrinology & Metabolism, published February 23, 2011, 10.1210/jc.2010-2642

HOXA10 Promotes Cell Invasion and MMP-3 Expression Via TGFβ2-Mediated Activation of the p38 MAPK Pathway in Pancreatic Cancer Cells

2014 ◽  
Vol 59 (7) ◽  
pp. 1442-1451 ◽  
Author(s):  
Xian-Ping Cui ◽  
Cheng-Kun Qin ◽  
Zhen-Hai Zhang ◽  
Zhong-Xue Su ◽  
Xin Liu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Cell Invasion ◽  
Mapk Pathway ◽  
Pancreatic Cancer Cells ◽  
P38 Mapk Pathway

scholarly journals Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0174591 ◽  
Author(s):  
Arulkumar Nagappan ◽  
Won Sup Lee ◽  
Jeong Won Yun ◽  
Jing Nan Lu ◽  
Seong-Hwan Chang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Mapk Activation ◽  
Human Colon Cancer Cells

Effect of polyamide nanoparticles on apoptosis of colon cancer cells induced by survivin antisense oligonucleotide

2020 ◽  
Vol 10 (9) ◽  
pp. 1573-1580
Author(s):  
Yongqiang Xu ◽  
Weibiao Ye ◽  
Chan Zhou ◽  
Yuling Li ◽  
Jianfang He
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Caspase 3 ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Significant Difference ◽  
Microfilament System ◽  
Human Colon Cancer Cells

In this study, we aimed to observe the effect of polyamidoamine (PAMAM) liposomes on the apoptosis of human colon cancer cells induced by survivin antisense oligonucleotides (ASODNs). PAMAM liposomes and PAMAM were mixed with survivin ASODNs to obtain antisense gene transfection complexes. In addition, the zeta potentials and encapsulation rates of the complexes were measured. The two gene-containing complexes were transfected into HT-29 colon cancer cells to observe changes in cell morphology, detect the inhibitory effect on tumor cells and changes in apoptosis, and observe changes in the cytoskeleton microfilament system using laser confocal microscopy. Caspase-3 activity in the cells was determined using a kinase activity assay, and p38 mitogen-activated protein kinase (p38 MAPK) activity in the cells was measured using immunoprecipitation analysis. The results showed that the zeta potential of the PAMAM liposome-survivin-ASODN complex was higher than that of the PAMAM-survivin-ASODN complex (P < 0.05). There was no significant difference in the gene encapsulation rates between the two complexes (P > 0.05). PAMAM liposomes may efficiently deliver survivin ASODNs to human colon cancer cells, reduce the expression of survivin protein and at the same time induce G2/M phase arrest in cells, and activate caspase-3 by activating p38 MAPK. Cleavage of caspase-3 destroys the structure of the intracellular skeletal microfilament system, finally resulting in apoptosis of colon cancer cells.

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