Suppression of the tumorigenic phenotype of a rat liver epithelial tumor cell line by the p11.2–p12 region of human chromosome 11

1995 ◽  
Vol 13 (4) ◽  
pp. 220-232 ◽  
Author(s):  
William B. Coleman ◽  
Karen D. McCullough ◽  
Gwyn L. Esch ◽  
Chris J. Civalier ◽  
Elizabeth Livanos ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Tumor Cell ◽  
Cell Line ◽  
Rat Liver ◽  
Tumor Cell Line ◽  
Chromosome 11 ◽  
Epithelial Tumor ◽  
Epithelial Tumor Cell

Introduction of a normal human chromosome 11 into a Wilms' tumor cell line controls its tumorigenic expression

Science ◽  
1987 ◽  
Vol 236 (4798) ◽  
pp. 175-180 ◽  
Author(s):  
B. Weissman ◽  
P. Saxon ◽  
Pasquale ◽  
G. Jones ◽  
A. Geiser ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Tumor Cell ◽  
Cell Line ◽  
Wilms Tumor ◽  
Tumor Cell Line ◽  
Chromosome 11 ◽  
Normal Human

scholarly journals Phosphatidylcholine Passes by Paracellular Transport to the Apical Side of the Polarized Biliary Tumor Cell Line Mz-ChA-1

2019 ◽  
Vol 20 (16) ◽  
pp. 4034
Author(s):  
Wolfgang Stremmel ◽  
Simone Staffer ◽  
Ralf Weiskirchen
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Electrical Potential ◽  
Tumor Cell Line ◽  
Biliary Tree ◽  
Paracellular Transport ◽  
Epithelial Tumor ◽  
Epithelial Tumor Cell ◽  
Apical Side ◽  
Mucus Barrier

Phosphatidylcholine (PC) translocation into mucus of the intestine was shown to occur via a paracellular transport across the apical/lateral tight junction (TJ) barrier. In case this could also be operative in biliary epithelial cells, this may have implication for the pathogenesis of primary sclerosing cholangitis (PSC). We here evaluated the transport of PC across polarized cholangiocytes. Therefore, the biliary tumor cell line Mz-ChA-1 was grown to confluency. In transwell culture systems the translocation of PC to the apical compartment was analyzed. After 21 days in culture, polarized Mz-ChA-1 cells revealed a predominant apical translocation of choline containing phospholipids including PC with minimal intracellular accumulation. Transport was suppressed by TJ destruction employing chemical inhibitors and pretreatment with siRNA to TJ forming proteins as well as the apical transmembrane mucin 3 as PC acceptor. Apical translocation was dependent on a negative apical electrical potential created by the cystic fibrosis transmembrane conductance regulator (CFTR) and the anion exchange protein 2 (AE2). It was stimulated by apical application of secretory mucins. The results indicated the existence of a paracellular PC passage across apical/lateral TJ of the polarized biliary epithelial tumor cell line Mz-ChA-1. This has implication for the generation of a protective mucus barrier in the biliary tree.

COX-2 and survivin reduction may play a role in berberine-induced apoptosis in human ductal breast epithelial tumor cell line

Tumor Biology ◽  
2011 ◽  
Vol 33 (1) ◽  
pp. 207-214 ◽  
Author(s):  
Yaghub Pazhang ◽  
Shahin Ahmadian ◽  
Nader Javadifar ◽  
Mahshid Shafiezadeh
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Epithelial Tumor ◽  
Epithelial Tumor Cell ◽  
Cox 2 ◽  
Breast Epithelial ◽  
Induced Apoptosis

Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa

1989 ◽  
Vol 2 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Minoru Koi ◽  
Hiroyuki Morita ◽  
Hideto Yamada ◽  
Hitoshi Satoh ◽  
J. Carl Barrett ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Cervical Tumor ◽  
Chromosome 11 ◽  
Normal Human
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