The electric field distributions in anatomical head models during transcranial direct current stimulation for post-stroke rehabilitation

2017 ◽  
Vol 44 (1) ◽  
pp. 262-271 ◽  
Author(s):  
Zoi Manoli ◽  
Marta Parazzini ◽  
Paolo Ravazzani ◽  
Theodoros Samaras
Keyword(s):  
Electric Field ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Stroke Rehabilitation ◽  
Direct Current Stimulation ◽  
Post Stroke ◽  
Field Distributions

scholarly journals Multiscale Coupling of Transcranial Direct Current Stimulation to Neuron Electrodynamics: Modeling the Influence of the Transcranial Electric Field on Neuronal Depolarization

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Edward T. Dougherty ◽  
James C. Turner ◽  
Frank Vogel
Keyword(s):  
Electric Field ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Three Dimensional ◽  
Human Head ◽  
Multiscale Model ◽  
Medical Intervention ◽  
Medical Community ◽  
Computational Grids ◽  
Direct Current Stimulation

Transcranial direct current stimulation (tDCS) continues to demonstrate success as a medical intervention for neurodegenerative diseases, psychological conditions, and traumatic brain injury recovery. One aspect of tDCS still not fully comprehended is the influence of the tDCS electric field on neural functionality. To address this issue, we present a mathematical, multiscale model that couples tDCS administration to neuron electrodynamics. We demonstrate the model’s validity and medical applicability with computational simulations using an idealized two-dimensional domain and then an MRI-derived, three-dimensional human head geometry possessing inhomogeneous and anisotropic tissue conductivities. We exemplify the capabilities of these simulations with real-world tDCS electrode configurations and treatment parameters and compare the model’s predictions to those attained from medical research studies. The model is implemented using efficient numerical strategies and solution techniques to allow the use of fine computational grids needed by the medical community.

Determinants of the electric field during transcranial direct current stimulation

NeuroImage ◽  
2015 ◽  
Vol 109 ◽  
pp. 140-150 ◽  
Author(s):  
Alexander Opitz ◽  
Walter Paulus ◽  
Susanne Will ◽  
Andre Antunes ◽  
Axel Thielscher
Keyword(s):  
Electric Field ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation

Mood and cognitive effects of transcranial direct current stimulation in post-stroke depression

Neurocase ◽  
2011 ◽  
Vol 17 (4) ◽  
pp. 318-322 ◽  
Author(s):  
Viviane F. Bueno ◽  
Andre R. Brunoni ◽  
Paulo S. Boggio ◽  
Isabela M. Bensenor ◽  
Felipe Fregni
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Cognitive Effects ◽  
Direct Current Stimulation ◽  
Post Stroke ◽  
Post Stroke Depression

High-Definition Transcranial Direct Current Stimulation Improves Delayed Memory in Alzheimer’s Disease Patients: A Pilot Study Using Computational Modeling to Optimize Electrode Position

2021 ◽  
pp. 1-17
Author(s):  
Ingrid Daae Rasmussen ◽  
Nya Mehnwolo Boayue ◽  
Matthias Mittner ◽  
Martin Bystad ◽  
Ole K. Grnli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Electric Field ◽  
Computational Modeling ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Cortical Atrophy ◽  
Brain Anatomy ◽  
High Definition ◽  
Direct Current Stimulation

Background: The optimal stimulation parameters when using transcranial direct current stimulation (tDCS) to improve memory performance in patients with Alzheimer’s disease (AD) are lacking. In healthy individuals, inter-individual differences in brain anatomy significantly influence current distribution during tDCS, an effect that might be aggravated by variations in cortical atrophy in AD patients. Objective: To measure the effect of individualized HD-tDCS in AD patients. Methods: Nineteen AD patients were randomly assigned to receive active or sham high-definition tDCS (HD-tDCS). Computational modeling of the HD-tDCS-induced electric field in each patient’s brain was analyzed based on magnetic resonance imaging (MRI) scans. The chosen montage provided the highest net anodal electric field in the left dorsolateral prefrontal cortex (DLPFC). An accelerated HD-tDCS design was conducted (2 mA for 3×20 min) on two separate days. Pre- and post-intervention cognitive tests and T1 and T2-weighted MRI and diffusion tensor imaging data at baseline were analyzed. Results: Different montages were optimal for individual patients. The active HD-tDCS group improved significantly in delayed memory and MMSE performance compared to the sham group. Five participants in the active group had higher scores on delayed memory post HD-tDCS, four remained stable and one declined. The active HD-tDCS group had a significant positive correlation between fractional anisotropy in the anterior thalamic radiation and delayed memory score. Conclusion: HD-tDCS significantly improved delayed memory in AD. Our study can be regarded as a proof-of-concept attempt to increase tDCS efficacy. The present findings should be confirmed in larger samples.

Abstract P200: Transcranial Direct Current Stimulation in Post-Stroke Chronic Aphasia: A Double Blind Randomized Controlled Study

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Caroline Schnakers ◽  
Zhong Sheng Zheng ◽  
Henry Millan ◽  
Sharon Lee ◽  
Melissa Howard ◽  
...  
Keyword(s):  
Outcome Measures ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Superior Cerebellar Peduncle ◽  
Double Blind ◽  
Verbal Comprehension ◽  
Direct Current Stimulation ◽  
Post Stroke ◽  
Chronic Aphasia ◽  
Cerebellar Peduncle

Background: There is growing evidence even amongst those with chronic aphasia that transcranial direct current stimulation (tDCS) combined with behavioral speech therapy could boost language. However, current findings do not allow making strong recommendations for using tDCS in order to improve language in post-stroke aphasia. The efficacy of tDCS therefore still needs to be established using double-blind controlled randomized trials in large samples. Intervention: In this ongoing double-blind randomized placebo controlled trial study, participants were randomly assigned either to the tDCS group or to the sham group. Both groups had five consecutive days of 20 minutes session, using a FDA approved tDCS device (soterixmedical.com). Behavioral and neuroimaging data were performed the week before/after tDCS/sham intervention and again 3 months following treatment. Participants: 42 post-stroke patients with chronic aphasia (32 males; age: 61±11y; 0.9-18years post-injury; 32 ischemic stroke; 19 non-fluent aphasia). Eighteen patients were in the tDCS group. Main Outcome Measures: The Western Aphasia Battery-Revised (WAB-R), Communication Outcomes after Stroke, patient and family report (COAST). MRI Diffusion Tensor Imaging data (64 dir) were also collected. Statistical Analyses: Anova with repeated measures was used on the behavioral outcome measures with aphasia severity, age and time since injury as covariates in SPSS. The average fractional anisotropy (FA) and mean diffusivity (MD) were extracted per ROI from each participant and timepoint. Main Results: a) Behavioral. Groups differed, pre/post intervention, on the WAB-R total score, for the Auditory-Verbal Comprehension and Repetition subscores; b) Neuroimaging. Change in Spontaneous Speech and Auditory Verbal Comprehension negatively correlated with change in mean MD and FA, respectively, in Superior Cerebellar Peduncle for tDCS, but not sham. Conclusion: Our preliminary findings show a higher improvement in language functions (for both receptive and expressive language skills) in response to treatment (vs. sham). Neuroplasticity was observed in superior cerebellar peduncle in response to tDCS mediated language improvement.

Transcranial direct current stimulation for the treatment of post-stroke depression: results from a randomised, sham-controlled, double-blinded trial

2016 ◽  
Vol 88 (2) ◽  
pp. 170-175 ◽  
Author(s):  
Leandro C L Valiengo ◽  
Alessandra C Goulart ◽  
Janaina F de Oliveira ◽  
Isabela M Benseñor ◽  
Paulo A Lotufo ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation ◽  
Post Stroke ◽  
Post Stroke Depression ◽  
Double Blinded ◽  
Blinded Trial
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