scholarly journals Deep‐learning model observer for a low‐contrast hepatic metastases localization task in computed tomography

2021 ◽  
Author(s):  
Hao Gong ◽  
Joel G. Fletcher ◽  
Jay P. Heiken ◽  
Michael L. Wells ◽  
Shuai Leng ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Deep Learning ◽  
Hepatic Metastases ◽  
Learning Model ◽  
Localization Task ◽  
Low Contrast ◽  
Model Observer ◽  
Deep Learning Model

scholarly journals A deep learning model observer for use in alterative forced choice virtual clinical trials

2018 ◽  
Author(s):  
Majdi Alnowami ◽  
G. Mills ◽  
Kenneth Young ◽  
David R. Dance ◽  
Muhammad Awais ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Deep Learning ◽  
Learning Model ◽  
Forced Choice ◽  
Model Observer ◽  
Deep Learning Model

scholarly journals Predicting EGFR mutation status in lung adenocarcinoma on computed tomography image using deep learning

2019 ◽  
Vol 53 (3) ◽  
pp. 1800986 ◽  
Author(s):  
Shuo Wang ◽  
Jingyun Shi ◽  
Zhaoxiang Ye ◽  
Di Dong ◽  
Dongdong Yu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Deep Learning ◽  
Lung Adenocarcinoma ◽  
Egfr Mutation ◽  
Treatment Guidelines ◽  
Learning Model ◽  
Ct Images ◽  
Mutation Status ◽  
Non Invasive ◽  
Deep Learning Model

Epidermal growth factor receptor (EGFR) genotyping is critical for treatment guidelines such as the use of tyrosine kinase inhibitors in lung adenocarcinoma. Conventional identification of EGFR genotype requires biopsy and sequence testing which is invasive and may suffer from the difficulty of accessing tissue samples. Here, we propose a deep learning model to predict EGFR mutation status in lung adenocarcinoma using non-invasive computed tomography (CT).We retrospectively collected data from 844 lung adenocarcinoma patients with pre-operative CT images, EGFR mutation and clinical information from two hospitals. An end-to-end deep learning model was proposed to predict the EGFR mutation status by CT scanning.By training in 14 926 CT images, the deep learning model achieved encouraging predictive performance in both the primary cohort (n=603; AUC 0.85, 95% CI 0.83–0.88) and the independent validation cohort (n=241; AUC 0.81, 95% CI 0.79–0.83), which showed significant improvement over previous studies using hand-crafted CT features or clinical characteristics (p<0.001). The deep learning score demonstrated significant differences in EGFR-mutant and EGFR-wild type tumours (p<0.001).Since CT is routinely used in lung cancer diagnosis, the deep learning model provides a non-invasive and easy-to-use method for EGFR mutation status prediction.

Use of Artificial Intelligence Deep Learning to Determine the Malignant Potential of Pancreatic Cystic Neoplasms With Preoperative Computed Tomography Imaging

2020 ◽  
pp. 000313482095377
Author(s):  
Michael D. Watson ◽  
William B. Lyman ◽  
Michael J. Passeri ◽  
Keith J. Murphy ◽  
John P. Sarantou ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Deep Learning ◽  
Learning Model ◽  
Consensus Guidelines ◽  
Benign Lesions ◽  
Cystic Neoplasms ◽  
Advanced Neoplasia ◽  
Malignant Lesions ◽  
Pancreatic Cystic Neoplasms ◽  
Deep Learning Model

Background Society consensus guidelines are commonly used to guide management of pancreatic cystic neoplasms (PCNs). However, downsides of these guidelines include unnecessary surgery and missed malignancy. The aim of this study was to use computed tomography (CT)-guided deep learning techniques to predict malignancy of PCNs. Materials and Methods Patients with PCNs who underwent resection were retrospectively reviewed. Axial images of the mucinous cystic neoplasms were collected and based on final pathology were assigned a binary outcome of advanced neoplasia or benign. Advanced neoplasia was defined as adenocarcinoma or intraductal papillary mucinous neoplasm with high-grade dysplasia. A convolutional neural network (CNN) deep learning model was trained on 66% of images, and this trained model was used to test 33% of images. Predictions from the deep learning model were compared to Fukuoka guidelines. Results Twenty-seven patients met the inclusion criteria, with 18 used for training and 9 for model testing. The trained deep learning model correctly predicted 3 of 3 malignant lesions and 5 of 6 benign lesions. Fukuoka guidelines correctly classified 2 of 3 malignant lesions as high risk and 4 of 6 benign lesions as worrisome. Following deep learning model predictions would have avoided 1 missed malignancy and 1 unnecessary operation. Discussion In this pilot study, a deep learning model correctly classified 8 of 9 PCNs and performed better than consensus guidelines. Deep learning can be used to predict malignancy of PCNs; however, further model improvements are necessary before clinical use.

Using transfer learning for a deep learning model observer

2019 ◽  
Author(s):  
William Murphy ◽  
Mark D. Halling-Brown ◽  
Emma Lewis ◽  
Premkumar Elangovan ◽  
Kenneth C. Young ◽  
...  
Keyword(s):  
Deep Learning ◽  
Transfer Learning ◽  
Learning Model ◽  
Model Observer ◽  
Deep Learning Model

scholarly journals Automatic detection of acute ischemic stroke using non-contrast computed tomography and two-stage deep learning model

2020 ◽  
Vol 196 ◽  
pp. 105711
Author(s):  
Mizuho Nishio ◽  
Sho Koyasu ◽  
Shunjiro Noguchi ◽  
Takao Kiguchi ◽  
Kanako Nakatsu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Ischemic Stroke ◽  
Deep Learning ◽  
Acute Ischemic Stroke ◽  
Automatic Detection ◽  
Learning Model ◽  
Two Stage ◽  
Deep Learning Model
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