scholarly journals Measurement of synovial tissue volume in knee osteoarthritis using a semiautomated MRI‐based quantitative approach

2019 ◽  
Vol 81 (5) ◽  
pp. 3056-3064 ◽  
Author(s):  
Thomas A. Perry ◽  
Andrew Gait ◽  
Terence W. O’Neill ◽  
Matthew J. Parkes ◽  
Richard Hodgson ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Synovial Tissue ◽  
Quantitative Approach ◽  
Tissue Volume

scholarly journals Effect of Vitamin D supplementation on synovial tissue volume and subchondral bone marrow lesion volume in symptomatic knee osteoarthritis

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Thomas A. Perry ◽  
Matthew J. Parkes ◽  
Richard Hodgson ◽  
David T. Felson ◽  
Terence W. O’Neill ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Vitamin D ◽  
Knee Osteoarthritis ◽  
Synovial Tissue ◽  
Subchondral Bone ◽  
Vitamin D Supplementation ◽  
Lesion Volume ◽  
Tissue Volume ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

scholarly journals Synovial tissue volume: a treatment target in knee osteoarthritis (OA)

2015 ◽  
Vol 75 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Terence W O'Neill ◽  
Matthew J Parkes ◽  
Nasimah Maricar ◽  
Elizabeth J Marjanovic ◽  
Richard Hodgson ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Synovial Tissue ◽  
Treatment Target ◽  
Tissue Volume

scholarly journals The effect of synovial tissue volume shrinking on pain relief for knee osteoarthritis was overestimated or not?

2015 ◽  
Vol 74 (12) ◽  
pp. e64-e64
Author(s):  
Jie Wei ◽  
Chao Zeng ◽  
Guang-hua Lei
Keyword(s):  
Pain Relief ◽  
Knee Osteoarthritis ◽  
Synovial Tissue ◽  
Tissue Volume

scholarly journals Effect of vitamin d therapy on synovial tissue volume and bone marrow lesions in symptomatic knee osteoarthritis

2018 ◽  
Vol 26 ◽  
pp. S304-S305 ◽  
Author(s):  
T.A. Perry ◽  
T.W. O'Neill ◽  
M.J. Parkes ◽  
D.T. Felson ◽  
R. Hodgson ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Vitamin D ◽  
Knee Osteoarthritis ◽  
Synovial Tissue ◽  
Bone Marrow Lesions ◽  
Tissue Volume ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

scholarly journals Response to: ‘The effect of synovial tissue volume shrinking on pain relief for knee osteoarthritis was overestimated or not?’ by Weiet al

2015 ◽  
Vol 74 (12) ◽  
pp. e65-e65
Author(s):  
Terence W O'Neill ◽  
Matthew J Parkes ◽  
Nasimah Maricar ◽  
Elizabeth J Marjanovic ◽  
Richard Hodgson ◽  
...  
Keyword(s):  
Pain Relief ◽  
Knee Osteoarthritis ◽  
Synovial Tissue ◽  
Tissue Volume

scholarly journals Reduction in synovial tissue volume following intra-articular steroid injection in knee osteoarthritis

2012 ◽  
Vol 20 ◽  
pp. S217
Author(s):  
T.W. O'Neill ◽  
L.M. Forsythe ◽  
M.J. Parkes ◽  
E. Marjanovic ◽  
A. Gait ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Synovial Tissue ◽  
Steroid Injection ◽  
Tissue Volume

scholarly journals Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis

2010 ◽  
Vol 35 (6) ◽  
pp. 831-838 ◽  
Author(s):  
Liang Ning ◽  
Muneaki Ishijima ◽  
Haruka Kaneko ◽  
Hidetake Kurihara ◽  
Eri Arikawa-Hirasawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Knee Osteoarthritis ◽  
Synovial Tissue ◽  
Inflammatory Mediators ◽  
Medial Knee ◽  
Expression Levels ◽  
Medial Knee Osteoarthritis

scholarly journals 015 COMPARISON OF THE EXPRESSION PROFILES OF SYNOVIAL TISSUE INFLAMMATION BETWEEN END-STAGE AND PROGRESSIVE KNEE OSTEOARTHRITIS

2009 ◽  
Vol 17 ◽  
pp. S17 ◽  
Author(s):  
N. Liang ◽  
H. Kaneko ◽  
M. Ishijima ◽  
M. Kubota ◽  
I. Futami ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Synovial Tissue ◽  
Expression Profiles ◽  
Tissue Inflammation ◽  
End Stage

FRI0303 Degree of synovitis on MRI is correlated with histological and macroscopic features of synovial tissue inflammation in knee osteoarthritis

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 416.3-417
Author(s):  
B. de Lange-Brokaar ◽  
A. Ioan-Facsinay ◽  
E. Yusuf ◽  
W. Visser ◽  
S. Andersen ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Synovial Tissue ◽  
Tissue Inflammation

scholarly journals Efficacy and Mechanism of Electroacupuncture Treatment of Rabbits With Different Degrees of Knee Osteoarthritis: A Study Based on Synovial Innate Immune Response

2021 ◽  
Vol 12 ◽  
Author(s):  
Anmin Ruan ◽  
Qingfu Wang ◽  
Yufeng Ma ◽  
Dong Zhang ◽  
Lili Yang ◽  
...  
Keyword(s):  
Immune Response ◽  
Western Blot ◽  
Knee Osteoarthritis ◽  
Synovial Tissue ◽  
Innate Immune Response ◽  
Synovial Membrane ◽  
Innate Immune ◽  
Cartilage Tissue ◽  
Inflammatory Factors ◽  
And Cartilage

Knee osteoarthritis (KOA) is a chronic degenerative bone and joint disease, which is often clinically manifested as pain, joint swelling, and deformity. Its pathological manifestations are mainly synovial inflammation and cartilage degeneration. This study aims to investigate the efficacy of electro-acupuncture (EA) on model rabbits with varying degrees of KOA and to study the mechanism of EA on KOA based on the innate immune response. Mild and moderate rabbit KOA models were established using a modified Hluth method, and EA was given to both the mild and moderate model groups. The Lequesne-MG index was used to evaluate the behavioral changes in the rabbits before and after EA treatment. Morphological changes in the synovial membrane and cartilage of each group were observed by H&E staining. The Mankin scoring standard and the Krenn scoring standard were used to score the pathology of the cartilage tissue and synovial tissue, respectively. The inflammatory factors and metalloproteinases were detected in the serum of each group by ELISA. The protein and messenger RNA (mRNA) expressions of important elements related to Toll-like receptors (TLRs)-mediated innate immune response in the synovial tissue were detected by Western blot and quantitative PCR (qPCR). The Lequesne-MG index score of the rabbits gradually increased with the modeling prolonged but decreased significantly after EA treatment, indicating that EA has a better effect on alleviating the pain and improving the dysfunction. The morphological analysis showed that the inflammation of and the damage to the synovial membrane and the cartilage tissue gradually deteriorated with the modeling prolonged. However, the synovial membrane inflammation was significantly relieved after EA treatment, and the cartilage injury showed signs of repair. The ELISA analysis showed that, with the modeling prolonged, the serum-related inflammatory factors and mechanism of metalloproteinases gradually increased but decreased after EA treatment. The tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and matrix metalloproteinase3 (MMP3) of EA1 group were significantly lower than those of EA2 group. Both Western blot and qPCR results showed that the protein and mRNA expressions of the elements related to the innate immune response in the synovial membrane increased gradually with the modeling prolonged, but decreased significantly after EA treatment. Additionally, the expression of some components in EA1 group was significantly lower than that in EA2 group. These results confirm that synovial inflammation gradually aggravated with time from the early to mid-stage of KOA. EA alleviated the inflammation and histological changes in KOA rabbits by inhibiting the TLRs-mediated innate synovial immune response. This suggests that using EA in the early stage of KOA may achieve a desirable efficacy.

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