scholarly journals Recent advances in therapies utilizing superabsorbent hydrogel technology for weight management: A review

2021 ◽  
Author(s):  
Louis J. Aronne ◽  
John E. Anderson ◽  
Alessandro Sannino ◽  
Elaine Chiquette
Keyword(s):  
Weight Management ◽  
Superabsorbent Hydrogel ◽  
Recent Advances

Oral Superabsorbent Hydrogel (Plenity) for Weight Management

2020 ◽  
pp. 106002802098304
Author(s):  
Alexa Pass ◽  
Damian Bialonczyk ◽  
Elaine Chiquette ◽  
Jennifer D. Goldman
Keyword(s):  
Weight Management ◽  
Safety Profile ◽  
Data Extraction ◽  
Safety Data ◽  
Clinical Trial Data ◽  
Superabsorbent Hydrogel ◽  
Study Selection ◽  
Significant Difference ◽  
Favorable Safety ◽  
Comorbidity Status

Objective To describe the mechanism, clinical trial data, adverse effects, and potential role in therapy of an oral superabsorbent hydrogel (OSH) for weight management. Data Sources A literature search was completed using MEDLINE and Google Scholar using the following search terms: oral superabsorbent hydrogel, Plenity, and Gelesis100 (September 1999 to July 2020). Abstracts and posters were identified from relevant scientific congress archives and published supplements. Study Selection and Data Extraction All available studies were considered. Only human studies were used for drug interaction, efficacy, and safety data. Data Synthesis OSH is a first-in-class, nonsystemic agent for weight management. It is indicated for use in patients with a body mass index (BMI) of 25 to 40 kg/m2 regardless of comorbidity status. OSH functions primarily through space occupancy in the stomach and small intestine. Studies have demonstrated that OSH has modest weight loss efficacy and a favorable safety profile, with no significant difference in overall adverse events compared with placebo. Relevance to Patient Care and Clinical Practice OSH is one of the only prescription antiobesity therapeutics (AOTs) that can be utilized in overweight patients with BMI equal to 25 to 30 kg/m2, regardless of comorbidity status. Given its nonsystemic mechanism of action and safety profile, OSH may help shift the focus of weight management toward patients with a lower BMI. Conclusions OSH offers a nonsystemic approach to weight management for patients who are diagnosed with overweight or obesity. As an alternative option to current pharmacological AOTs, OSH may address an existing clinical gap in weight management.

25 Nutrigenetics and long term weight management: recent advances

2010 ◽  
Vol 5 (1) ◽  
pp. 13-14
Author(s):  
B. Weber
Keyword(s):  
Weight Management ◽  
Recent Advances

Emerging Insights in Weight Management and Prevention: Implications for Practice and Research

2020 ◽  
Author(s):  
Eric Doucet ◽  
Kevin Hall ◽  
Andrea Miller ◽  
Valerie H Taylor ◽  
Maria Ricupero ◽  
...  
Keyword(s):  
Mental Illness ◽  
Weight Loss ◽  
Energy Balance ◽  
Health System ◽  
Weight Management ◽  
Treatment Approach ◽  
Future Research ◽  
Multiple Factors ◽  
Recent Advances ◽  
Foundational Research

Recent advances in foundational research on energy balance and weight loss shed new light on earlier findings. Emerging evidence and insights around mental illness and client centred, weight inclusive approaches have implications for practitioners. This paper provides an overview of opinions from invited experts who presented at the Canadian Nutrition Society Thematic Conference in January 2019. Key findings were: • Weight loss involves an interplay of multiple factors, not diet alone • There is no “best diet” or treatment approach for weight loss • Future research should involve minimizing weight loss countermeasures and new health system-based approaches aimed at improving health.

Recent Advances in High Dispersion Spectroscopy of Globular Cluster Stars

1988 ◽  
Vol 132 ◽  
pp. 525-530
Author(s):  
Raffaele G. Gratton
Keyword(s):  
Globular Cluster ◽  
Globular Clusters ◽  
High Dispersion ◽  
Photographic Material ◽  
Recent Advances ◽  
Metal Abundances ◽  
Ccd Detectors ◽  
Major Progress

The use CCD detectors has allowed a major progress in abundance derivations for globular cluster stars in the last years. Abundances deduced from high dispersion spectra now correlates well with other abundance indicators. I discuss some problems concerning the derivation of accurate metal abundances for globular clusters using high dispersion spectra from both the old photographic and the most recent CCD data. The discrepant low abundances found by Cohen (1980), from photographic material for M71 giants, are found to be due to the use of too high microturbulences.

Chelation-assisted transition metal-catalysed C–H chalcogenylations

2020 ◽  
Vol 7 (8) ◽  
pp. 1022-1060 ◽  
Author(s):  
Wenbo Ma ◽  
Nikolaos Kaplaneris ◽  
Xinyue Fang ◽  
Linghui Gu ◽  
Ruhuai Mei ◽  
...  
Keyword(s):  
Transition Metal ◽  
Recent Advances ◽  
Site Selectivity ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This review summarizes recent advances in C–S and C–Se formations via transition metal-catalyzed C–H functionalization utilizing directing groups to control the site-selectivity.

Nucleosome dynamics

2006 ◽  
Vol 73 ◽  
pp. 109-119 ◽  
Author(s):  
Chris Stockdale ◽  
Michael Bruno ◽  
Helder Ferreira ◽  
Elisa Garcia-Wilson ◽  
Nicola Wiechens ◽  
...  
Keyword(s):  
High Resolution ◽  
Chromatin Structure ◽  
Current Knowledge ◽  
Dynamic Properties ◽  
Structure And Dynamics ◽  
Nucleosome Dynamics ◽  
Sharp Focus ◽  
Recent Advances ◽  
Insight Into ◽  
Chromatin Structure And Dynamics

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.

Recent Advances in the Treatment of Pulmonary Tuberculosis

1950 ◽  
Vol 34 (5) ◽  
pp. 1363-1380
Author(s):  
Theodore L. Badger ◽  
William E. Patton
Keyword(s):  
Pulmonary Tuberculosis ◽  
Recent Advances

Recent Advances in Immunology with Specific Reference to Otolaryngology

1985 ◽  
Vol 18 (4) ◽  
pp. 821-832
Author(s):  
Robert Naderto
Keyword(s):  
Specific Reference ◽  
Recent Advances

Recent Advances in Thyroid Imaging

1990 ◽  
Vol 23 (2) ◽  
pp. 251-270
Author(s):  
Martin P. Sandler, MD ◽  
James A. Patton ◽  
Robert H. Ossoff
Keyword(s):  
Thyroid Imaging ◽  
Recent Advances

Abstract #615: Hispanic People Achieve Clinically Significant Weight loss with Liraglutide 3.0 Mg for Weight Management

2015 ◽  
Vol 21 ◽  
pp. 121
Author(s):  
Patrick O’Neil ◽  
W. Timothy Garvey ◽  
J. Michael Gonzalez-Campoy ◽  
Pablo Mora ◽  
Rafael Violante Ortiz ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Management ◽  
Significant Weight Loss ◽  
Hispanic People ◽  
Clinically Significant
Sign in / Sign up

Export Citation Format

Share Document